Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
IFs as Critical Regulators in Health and Disease
Discussion Leaders: Milos Pekny (University of Gothenburg, Sweden) and Diana Toivola (Åbo Akademi University, Finland)
7:40 pm - 8:00 pm
Introduction by Discussion Leader: IFs in Health and Disease: Unifying Themes, Emerging Concepts
8:00 pm - 8:25 pm
Pierre Coulombe (University of Michigan, USA)
"Newly Defined Roles for Keratins in and Around the Nucleus"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Valerie Weaver (University of California, San Francisco, USA)
"Tissue Rheology in Disease Pathogenesis"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
CNS: IFs in Neurodegeneration, Neuroplasticity and Regeneration
Discussion Leader: Sandrine Etienne-Manneville (Institut Pasteur, CNRS, France)
9:00 am - 9:15 am
Tracy Hagemann (University of Wisconsin-Madison, USA)
"Targeting GFAP as a Treatment Strategy in Alexander Disease"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Elly Hol (Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands)
"GFAP and Reactive Gliosis in Neurodegenerative Diseases"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Ulrika Wilhelmsson (University of Gothenburg, Sweden)
"Astrocyte IFs as a Target in Neurodegenerative Diseases"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
Ming-Der Perng (National Tsing Hua University, Taiwan)
"Postranlational Regulation of GFAP and Stress Responses in Neurodegeneration"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Rachel Battaglia (University of North Carolina at Chapel Hill School of Medicine, USA)
"Aberrant Processing of GFAP in Alexander Disease"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
Robert Zorec (University of Ljubljana, Slovenia)
"Cytoplasmic IFs and Vesicle Trafficking in Astrocytes"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Dolores Perez-Sala (Consejo Superior de Investigaciones Científicas (CSIC), Spain)
"GFAP as an Antenna Sensing the Oxidative Stress"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Ronald Liem (Columbia University, USA)
"Abnormal Neurofilament Inclusions in Neuropathies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Cecilia Sahlgren (Åbo Akademi University, Finland)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intermediate Filaments, the Immune System and Repair
Discussion Leaders: Natasha Snider (University of North Carolina at Chapel Hill, USA) and Birgit Lane (Skin Research Institute of Singapore, Singapore)
6:00 pm - 6:15 pm
Nirit Mor-Vaknin (University of Michigan, USA)
"The Two-Edged Sword of Inflammation: Connection to IFs"
6:15 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
Andrei Gudkov (Roswell Park Comprehensive Cancer Center, USA)
"Secreated Vimentin as a Biomarker of Senescence and Its Recognition by Innate Immune System"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Martin Gregor (Institute of Molecular Genetics of the ASCR, v.v.i., Czech Republic)
"Plectin Controls Intestinal Epithelial Barrier"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:20 pm
Georgia Schäfer (University of Cape Town, South Africa)
"Non-Filamentous Vimentin Protein Binds to HPV16 Pseudovirions and Dampens Infection in a Murine Model"
7:20 pm - 7:25 pm
Discussion
7:25 pm - 7:35 pm
Franziska Lautenschlaeger (Leibniz Institute for New Materials, Germany)
"The Role of Vimentin in Leukocyte Amoeboid Migration"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Rudolf Leube (RWTH Aachen University, Germany)
"Assembly, Disassembly and Transport of Keratin Intermediate Filaments"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Intermediate Filaments in Cell Differentiation, Adhesion, Migration and Senescence
Discussion Leaders: Karen Ridge (Northwestern University, USA) and John Eriksson (Turku Centre for Biotechnology / University of Turku / Åbo Akademi University, Finland)
9:00 am - 9:15 am
Robert Goldman (Northwestern University, USA)
"IFs: Modulators of Stress Responses and Cell Energetics in Critical Times"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Masaki Inagaki (Mie University School of Medicine, Japan)
"Vimentin and Desmin Phosphorylation: Implications for Ontogenesis and Diseases"
9:40 am - 9:50 am
Discussion
9:50 am - 10:00 am
Joe Swift (Wellcome Trust Centre for Cell-Matrix Research, United Kingdom)
"Mechanosensitivity of Mesenchymal Stem Cells (MSCs) Is Abrogated in Senescence, Coincident with Changes at the Nuclear Lamina"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:45 am
Sophie Zinn-Justin (CEA, France)
"A Molecular Description of the Interaction Between Lamin A/C, Emerin, BAF and DNA"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
Emma van Bodegraven (Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands)
"GFAP Alternative Splicing in Astrocytoma and Laminin Signaling"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
Pascale Bomont (Institute for Neurosciences of Montpellier (INM), France)
"Fish-ing for Neurofilament Dynamics in Disease"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Sandrine Etienne-Manneville (Institut Pasteur, CNRS, France)
"IFs, the Rest of the Cytoskeleton and Migration"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Cecilia Sahlgren (Åbo Akademi University, Finland)
"Vimentin Regulation of Notch Signaling During Vascular Remodeling"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Heart and Muscle Control in Human Diseases
Discussion Leaders: Elly Hol (Brain Center Rudolf Magnus, UMC Utrecht, The Netherlands) and Rudolf Leube (RWTH Aachen University, Germany)
6:00 pm - 6:15 pm
Gisele Bonne (Sorbonne Université / INSERM UMRS974, France)
"Laminopathies: Unveiling the Pathophysiology"
6:15 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
Howard Worman (Columbia University, USA)
"Lamins in Cardiomyopahies: Partners, Interactions, Mechanisms and Model Interventions"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Tyler Kirby (Cornell University, USA)
"Lamin Mutations Cause Mechanically-Induced Nuclear Envelope Rupture and DNA Damage in Muscle Fibers"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:15 pm
Delphine Larrieu (University of Cambridge, United Kingdom)
"NAT10 Inhibition Normalizes HGPS Cells by Rebalancing the Transportin-1 Nuclear Import Pathway"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Giulio Agnetti (Johns Hopkins University, USA)
"Desmin Aggregation and O-GlcNacylation in Ischemia Reperfusion Injury"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:45 pm
Brian Russo (Massachusetts General Hospital, USA)
"Intermediate Filaments Activate a Bacterial Secretion System"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regulating the Cell Microenvironment and Mechanotransduction
Discussion Leaders: Jan Lammerding (Cornell University, USA) and Clarissa Koch (Northwestern University, USA)
9:00 am - 9:20 am
Kristian Franze (University of Cambridge, United Kingdom)
"Soft or Stiff? Determinants and Consequences of Tissue-Dependent Rheological Properties of Scars"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yosef Gruenbaum (Hebrew University of Jerusalem, Israel)
"Rheology of Cell Nucleus: From Physics to Understanding Disease Mechanisms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:45 am
Dennis Discher (University of Pennsylvania, USA)
"Mechanosensing of Cell Nucleus in Development and When Things Go Wrong"
10:45 am - 10:55 am
Discussion
10:55 am - 11:05 am
Oscar Stassen (Eindhoven University of Technology, The Netherlands)
"Vimentin and Notch Signalling in the Regulation of Vascular Homeostasis"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Laura Virtanen (University of Turku, Finland)
"Modelling of LMNA-Related Dilated Cardiomyopathy with iPSC-Derived Cardiomyocytes"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Eric Schirmer (University of Edinburgh, United Kingdom)
"Lamin A Molecular Compression and Sliding as Mechanisms Behind Nucleoskeleton Elasticity"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
From Intermediate Filament Structure to Diseases
Discussion Leaders: Gisele Bonne (Sorbonne Université / INSERM UMRS974, France) and Thomas Magin (Leipzig University, Germany)
6:00 pm - 6:15 pm
Roland Foisner (Medical University of Vienna, Austria)
"Lamins and Chromatin Organization"
6:15 pm - 6:25 pm
Discussion
6:25 pm - 6:35 pm
Luke Lairson (The Scripps Research Institute, USA)
"A Vimentin Targeting Small Molecule Induces Mitotic Catastrophe in Mesenchymally Transformed Cancers"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:50 pm
Joel Nyström (Åbo Akademi University, Finland)
"Loss of Keratin 8 Induces Deregulation of Caveolin-1 and Diminished Caveolar and Mitochondrial Ca2+ Responses in Colonic Epithelial Cells"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:10 pm
Pavel Hozak (Institute of Molecular Genetics of the ASCR, v.v.i., Czech Republic)
"Lipid-Containing Nuclear Structures in Genome Regulation"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:30 pm
Justin Jacob (Johns Hopkins Bloomberg School of Public Health, USA)
"Keratin 17: A Novel Regulator of Nuclear Morphology and Chromatin Organization"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Ohad Medalia (University of Zurich, Switzerland)
"Nuclear Lamins: Deciphering the Structure Helps to Infer the Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Intermediate Filament Biology: Connecting the Laboratory with the Clinic
Discussion Leaders: Yosef Gruenbaum (Hebrew University of Jerusalem, Israel) and Ming-Der Perng (National Tsing Hua University, Taiwan)
9:00 am - 9:15 am
John Eriksson (Turku Centre for Biotechnology / University of Turku / Åbo Akademi University, Finland)
"IFs as Determinants of Cellular Organization, Migration and Wound Healing"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Karen Ridge (Northwestern University, USA)
"Vimentin and the Innate Immunity"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Natasha Snider (University of North Carolina at Chapel Hill, USA)
"Pharmacological Targeting of IFs"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
Birgit Lane (Skin Research Institute of Singapore, Singapore)
"Targeting Keratins in Skin Diseases"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Pavel Strnad (University Hospital Aachen, Germany)
"Keratins in Liver Diseases"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Susana Gonzalo (Saint Louis University, USA)
"Mechanisms Underlying Genomic Instability in Laminopathies"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Clarissa Koch (Northwestern University, USA)
"Vimentin Is Required for the Innate Immune Response Following Influenza A Virus Infection"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Metabolic Regulation, Mitochondria and Intermediate Filaments
Discussion Leaders: Pascale Bomont (Institute for Neurosciences of Montpellier (INM), France) and Oscar Stassen (Eindhoven University of Technology, The Netherlands)
6:00 pm - 6:15 pm
Yassemi Capetanaki (Biomedical Research Foundation, Academy of Athens, Greece)
"Desmin and the Control of Mitochondrial Homeostatis"
6:15 pm - 6:25 pm
Discussion
6:25 pm - 6:40 pm
Thomas Magin (Leipzig University, Germany)
"Kelch Proteins as Caretakers of Keratins During Tissue Homeostasis and Disease"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Jasmine Robinson (University of North Carolina at Chapel Hill, USA)
"Widespread Accumulation and Aggregation or IF Proteins During Mammalian Aging and Partial Reversal by Lifelong Caloric Restriction"
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:20 pm
Diana Toivola (Åbo Akademi University, Finland)
"Keratins and Mitochondrial Morphology, Motility and Function"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
