| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Opening Keynote Session |
| Discussion Leader: Madan Babu (MRC-LMB, University of Cambridge) |
| 7:50 pm - 8:20 pm | Julie Forman-Kay (University of Toronto, Hospital for Sick Kids)
"Dynamic Complexes of IDPs in the Regulation of Cell Cycle, Translation and Ion Flux" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:42 pm | Kim Reynolds (University of Texas Southwestern Medical Center)
"Allosteric control through a heterogeneous spatial architecture within proteins" |
| 8:42 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Jeffrey Kelly (The Scripps Research Institute)
"Enhancing Protein Homeostasis to Ameliorate Degenerative Diseases" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Emerging Technologies for Studying Conformational Heterogeneity |
| Discussion Leader: Régis Pomès (University of Toronto, Hospital for Sick Kids) |
| 9:05 am - 9:30 am | Ashok Deniz (The Scripps Research Institute)
"Structural Biophysics of IDPs at Single Molecule Resolution" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Martin Blackledge (Institut de Biologie Structurale, Grenoble)
"Towards a Unified Conformational Understanding of the Dynamics of Intrinsic Disorder from NMR" |
| 10:05 am - 10:15 am | Discussion |
| 10:15 am - 10:40 am | Group Photo / Coffee Break |
| 10:40 am - 11:05 am | Claus Seidel (Heinrich-Heine University, Dusseldorf)
"High-precision FRET to Determine Dynamic Protein Structures and Dissect the Corresponding Inter-Conversion Pathways" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:40 am | Gerhard Hummer (NIDDK, National Institutes of Health)
"Assembling Supramolecular Complexes with Intrinsic Disorder by Simulation and Experiment" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:15 pm | Benjamin Schuler (University of Zurich)
"Dimensions and Dynamics of IDPs from Single Molecule Spectroscopy" |
| 12:15 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Phase Behavior, Molecular Recognition, and Evolution of IDPs |
| Discussion Leader: Patricia Clark (University of Notre Dame) |
| 7:40 pm - 8:05 pm | Kyou-Hoon Han (Korea Research Institute of Bioscience & Biotechnology)
"Understanding the Level of Unstructuredness in IDPs" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Sonia Longhi (CNRS & Universities Aix-Marseille I & II)
"Molecular Insights Into the NTAIL-PXD Interaction from Biophysical and In Vitro Evolution Approaches" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Eugene Shakhnovich (Harvard University)
"Interplay of Protein Biophysics and Cell Homeostasis Determines States of Proteins in Cytoplasm" |
| 9:15 pm - 9:25 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Transcriptional Activation & Regulation |
| Discussion Leader: Monika Fuxreiter (University of Debrecen, Hungary) |
| 9:10 am - 9:35 am | Remy Loris (Vrije Universiteit Brussel)
"Intrinsic Disorder in Bacterial Regulation Mechanisms: Toxin-Antitoxin Modules as a Paradigm" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Timothy Lohman (Washington University in St. Louis)
"E. coli SSB - Four Tails of Regulation" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Yaakov Levy (The Weizmann Research Institute)
"Modulating Protein-DNA Interactions by Post-Translational Modifications at Disordered Regions" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Jianhan Chen (Kansas State University)
"Mechanisms for Efficient Folding Upon Binding: Residual Structures, Conformational Flexibility and Electrostatics" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Trevor Creamer (University of Kentucky)
"Disordered Activation of Calcineurin"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | IDP Proteolysis & Modifications |
| Discussion Leader: James Bardwell (University of Michigan) |
| 7:40 pm - 8:05 pm | Ursula Jakob (University of Michigan)
"Order out of Disorder - Mechanism of an Intrinsically Disordered Chaperone" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:40 pm | Yosef Shaul (The Weizmann Research Institute)
"Mechanisms of Proteasomal Degradation of IDPs" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Hilal Lashuel (EPFL, Swiss Federal Institute of Technology)
"Elucidating the Role of Post-Translational Modifications in Regulating the Structure, Aggregation and Toxicity of α-synuclein" |
| 9:15 pm - 9:25 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Functionally Relevant & Disease-Related Self-Assembly |
| Discussion Leader: Rohit Pappu (Washington University) |
| 9:05 am - 9:35 am | Susan Lindquist (MIT, Whitehead Institute)
"The Link Between Environmental Stress and Protein Folding Drives Evolutionary Change"
|
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Joel Schneider (NCI, National Institutes of Health)
"Form Follows Function: Architecture of Self Assembled Materials" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | David Eliezer (Cornell Weill Medical College)
"Disorder and Order in Neurotransmission, Axonal Development, Parkinson's and Alzheimer's Diseases" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Thomas Scheibel (Universitat Bayreuth)
"Bringing Order to Disordered Proteins: The Role of Terminal Domains in Spider Silk Proteins" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Sheena Radford (University of Leeds)
"Molecular dissection of protein misfolding mechanisms" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
| 7:30 pm - 9:30 pm | Tagging, Processing, and Trafficking of IDPs and their Assemblies |
| Discussion Leader: Peter Tompa (Vrije Universiteit Brussel) |
| 7:30 pm - 7:55 pm | Edward Lemke (EMBL)
"From single molecules to supramolecular assemblies - Plasticity of Nup153, a major player in the nuclear pore complex" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:30 pm | Yuh Min Chook (University of Texas Southwestern Medical Center)
"The PY-NLS-IDPs in Nucleocytoplasmic Transport" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:05 pm | Andreas Matouschek (Northwestern University)
"The Role of Unstructured Regions in Proteasome Targeting" |
| 9:05 pm - 9:15 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Signaling Pathways |
| Discussion Leader: Tanja Mittag (St. Jude Children's Research Hospital) |
| 9:10 am - 9:35 am | Richard Kriwacki (St. Jude Children's Research Hospital)
"Functional Advantages of Intrinsic Disorder" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:10 am | Michael Rosen (University of Texas Southwestern Medical Center)
"Phase Transitions in the Assembly of Multivalent Signaling Proteins" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Jane Dyson (The Scripps Research Institute)
"Role of Disorder in Signal Transduction by NFκB" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Susan Taylor (University of California, San Diego)
"PKA: Dynamic Assembly of Macromolecular Scaffolds" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Rama Ranganathan (University of Texas Southwestern Medical Center)
"Evolutionary Principles of Protein Structure and Function" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Closing Keynote Session |
| Discussion Leader: Gary Daughdrill (University of South Florida) |
| 7:50 pm - 8:20 pm | Alan Fersht (MRC-LMB, University of Cambridge)
"p53 - Tohuvabohu" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:42 pm | Marija Buljan (MRC Laboratory of Molecular Biology, Cambridge)
"Tissue-specific splicing rewires protein interaction networks" |
| 8:42 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Vladimir Uversky (University of South Florida)
"Vivat, Disorder!" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |