| SATURDAY |
| 1:00 pm - 5:00 pm | Arrival and Check-in |
| 3:30 pm - 3:45 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:45 pm - 4:30 pm | Protein Disorder and the Structure/Function Paradigm |
| Discussion Leaders: Keith Dunker (Indiana University School of Medicine) and Lisette Fred (Georgetown University) |
| 3:45 pm - 4:00 pm | Ofrah Faust (The Hebrew University of Jerusalem)
"A Role for a Disordered Domain in Regulating Protein Oligomerization and Stability" |
| 4:00 pm - 4:05 pm | Discussion |
| 4:05 pm - 4:20 pm | Mihaly Varadi (VIB Flemish Institute for Biotechnology)
"Approaching the Function of IDPs by Structural Ensembles" |
| 4:20 pm - 4:30 pm | Discussion |
| 4:30 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Advances in Techniques to Identify and Characterize IDPs |
| Discussion Leaders: Jane Dyson (The Scripps Research Institute) and Peter Chung (University of California, Santa Barbara) |
| 7:30 pm - 7:50 pm | Sarah Shammas (University of Cambridge)
"Speed-Dating in the KIX System: Kinetics and Mechanism of Coupled Folding and Binding Reactions" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Tayler Croom-Perez (Pennsylvania State University)
"Expanding the Functional Proteome of an RNA Virus by Post-Translational Modification of a Protein Containing an Intrinsically Disordered Domain" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Jouhyun Jeon (University of Toronto)
"Identifying Anti-Proliferative Peptides Through High-Throughput Screening of Disordered Human Peptidome" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Kiersten Ruff (Washington University in St. Louis)
"Mechanistic Insights into Polyglutamine Aggregation in the Context of Flanking Sequences from Huntington" |
| 9:20 pm - 9:30 pm | Discussion |
| SUNDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | How IDPs Function in a Cellular Environment |
| Discussion Leaders: Sonia Longhi (CNRS / Universities Aix-Marseille I and II) and Justine Charon (INRA-France) |
| 9:00 am - 9:20 am | Assaf Biran (Weizmann Institute of Science)
"Regulation of Ubiquitin Independent Proteasomal Degradation of Intrinsically Disordered Proteins" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Andrea Soranno (University of Zürich)
"Single-Molecule Spectroscopy Reveals Polymer Effects of Disordered Proteins in Crowded Environments" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Wade Borcherds (University of South Florida)
"Disorder and Fractional Helicity of p53 Determine p53-Mdm2 Binding Affinity and Are Fine Tuned for Correct Cellular Signaling" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am - 10:50 am | Sanghita Banerjee (Indian Statistical Institute)
"Unstructured Housekeeping Proteins and Tissue Specific Interactions" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 12:30 pm | Poster Session II |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Career Panel |
| Discussion Leader: Rebecca Berlow (The Scripps Research Institute) |
|
Featuring:
- Simon Alberti (Max Planck Institute of Molecular Cell Biology and Genetics)
- Doug Barrick (Johns Hopkins University)
- Tanja Mittag (St. Jude Children's Research Hospital)
- Matthew Gage (Northern Arizona University)
|
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |