| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 4:00 pm - 6:00 pm | Welcome Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New channel biology and structure |
| 7:30 – 7:40 pm | Discussion leader: Merritt Maduke (Stanford) |
| 7:40 – 8:05 pm | Thomas Jentsch (Hamburg)
“Roles of CLC chloride channels gleaned from mouse models and human disease” |
| 8:15 – 8:40 pm | Raimund Dutzler (Rockefeller)
“X-ray structure of a ClC chloride channel at 3.0Å resolution: molecular basis of anion selectivity” |
| 8:50 – 9:15 pm | Fred Sigworth (Yale)
“Structural studies of the IP3 receptor and the Maxi-K channel using electron microscopy” |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group photo |
| 9:00 am - 12:30 pm | Ca2+-activated channels |
| 9:00 – 9:15 am | Discussion leader: Jianmin Cui (Case Western) |
| 9:15 – 9:40 am | Rick Aldrich (Stanford)
"BK channel gating" |
| 9:55 – 10:20 am | Mark Nelson (Vermont)
"Tuning calcium-activated potassium channels to regulate arterial function and blood pressure" |
| 10:35 am | Coffee break |
| 11:05 – 11:30 am | Jim Maylie (OHSU)
“Gating of the small conductance Ca2+- activated K+ channel” |
| 11:45 am -12:10 pm | Youxing Jiang (Rockefeller)
“Structure and Mechanism of a Calcium-Gated Potassium Channel” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New and Notable |
| 7:30 – 7:40 pm | Discussion leader: Alan Finkelstein (Einstein) |
| 7:40 – 7:55 pm | Dan Cox (Tufts)
"Elimination of the BKCa Channel’s High-Affinity Ca2+ Sensitivity" |
| 8:00 – 8:15 pm | Sharona Gordon (Seattle)
TBA |
| 8:20 – 8:35 pm | H. Peter Lu (Pacific NW)
“Conformational dynamics of an ion channel by simultaneous single-molecule fluorescence and patch recording” |
| 8:40 – 8:55 pm | Byung-Chang Suh (UW Seattle)
"Muscarinic modulation and recovery of M-current may be breakdown and resynthesis of PIP2." |
| 9:00 – 9:15 pm | Takashi Tsunenari (Johns Hopkins)
"The vitelliform macular dystrophy protein defines a new family of chloride channels" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | KcsA and other 2TM channels |
| 9:00 – 9:15 am | Discussion Leader: Jian Yang (Columbia) |
| 9:15 – 9:40 am | Lise Heginbotham (Yale)
“Biochemical and functional studies of the KcsA K++ Channel” |
| 9:55 – 10:20 am | Benoit Roux (Cornell Med)
“Computational studies of the potassium channel” |
| 10:35 am | Coffee break |
| 11:05 – 11:30 am | Zhe Lu (Penn)
"Coupling Kv channels' gating machinery to KcsA's pore" |
| 11:45 am -12:10 pm | Eitan Reuveny (Weizmann)
“Conformational rearrangements associated with GIRK channel gating: a FRET-based study" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Potassium channels and disease |
| 7:30 – 7:40 pm | Discussion leader: Steve Goldstein (Yale) |
| 7:40 – 8:05 pm | Fran Ashcroft (Oxford)
TBA |
| 8:15 – 8:40 pm | Maria Garcia (Merck)
"Identification of Potassium Channel Inhibitors for Therapeutic Use" |
| 8:50 – 9:15 pm | Ken Rhodes (Wyeth-Ayerst)
"(K)Chipping away at the KChIP/Kv4 Binding Interface" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Ligand-gated channels |
| 9:00 – 9:15 am | Discussion leader: Tony Auerbach (SUNY Buffalo) |
| 9:15 – 9:40 am | Guus Smit (NKI Amsterdam)
“Structure and function of AChBP, homolog of the ligand-binding domain of the nicotinic acetylcholine receptor.” |
| 9:55 – 10:20 am | Mark Mayer (NIH)
“A Molecular Mechanism for Desensitization of Glutamate Receptor Ion Channels” |
| 10:35 am | Coffee break |
| 11:05 – 11:30 am | Jun Chen (Utah)
"Gating mechanism of pacemaker channels" |
| 11:45 am -12:10 pm | Bill Zagotta (UW Seattle)
“Molecular mechanisms of gating and modulation of cyclic nucleotide-gated channels” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Channel trafficking and targeting |
| 7:30 – 7:40 pm | Discussion leader: Ligia Toro (UCLA) |
| 7:40 – 8:05 pm | Carol Deutsch (Penn)
“Kv channels: First steps” |
| 8:15 – 8:40 pm | Lily Jan (UCSF)
"Potassium channel trafficking" |
| 8:50 – 9:15 pm | Morgan Sheng (MIT)
“Subunit control of AMPA receptor exocytosis and endocytosis” |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Channels in neurons / TRP channels |
| 9:00 – 9:05 | Discussion leader: David Clapham (HHMI/Children’s) |
| 9:05 – 9:30 | Bruce Bean (Harvard)
“Subthreshold sodium channel gating and pacemaking of central neurons" |
| 9:45 – 10:10 | Jochen Roeper (Oxford)
“Make it simple – Linear coupling of pacemaker frequency and K channel transcription” |
| 10:30 am | Coffee break |
| 11:00 am – 12:30 pm | TRP channels |
| 11:00 – 11:05 | Discussion leader: David Clapham (HHMI/Children’s) |
| 11:05 – 11:30 | David McKemy (UCSF)
“Identification of a cold- and menthol-sensitive TRP channel involved in thermosensation” |
| 11:45 – 12:10 | Andrea Fleig (U Hawaii)
“TRP channels: calcium signaling and beyond” |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Calcium channels and signaling |
| 7:30 – 7:40 pm | Discussion leader: Bruce Bean (Harvard) |
| 7:40 – 8:05 pm | Ricardo Dolmetsch (Harvard)
"Excitation-transcription coupling: signaling from L-type calcium channels to the nucleus" |
| 8:15 – 8:40 pm | David Clapham (HHMI/Children’s)
“TRP channels” |
| 8:50 – 9:15 pm | David Yue (Johns Hopkins)
"Calcium channel regulation by calmodulin: interaction sites, prevalence, and functional stoichiometry" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
