SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 7:40 pm | Chair Welcome: John Adelman |
7:40 pm - 9:30 pm | Molecular Basis for Ion Channel Regulation |
7:40 pm - 7:50 pm | Discussion Leader: Ligia Toro (UCLA) |
7:50 pm - 8:10 pm | Bernd Fakler (University of Freiberg)
"The molecular microdomain of Cav2 channels - a view by functional protemics" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Amy Lee (Emory University)
"Ca2+- and voltage-dependent facilitation of Ca2+ channels" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Breaking News: Gisela Wilson (University of Michigan)
"Voltage-dependent, conductance-independent signaling activity of EAG potassium channels" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Breaking News: Nathan Dascal (Tel Aviv University)
"Regulation of GIRK channels by Gβγ and Gα subunits of G proteins" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Split Personalities |
9:00 am - 9:15 am | Discussion Leader: Chris Miller (Brandeis University) |
9:15 am - 9:55 am | Criss Hartzell (Emory University)
"Bestrophins are chloride channels and regulate Cav channels" |
9:55 am - 10:05 am | Discussion |
10:05 am | Coffee Break |
10:50 am - 11:30 am | Michael Kavanaugh (University of Montana)
"Ions moving in glutamate transporters, there and back again" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:20 pm | Merritt Maduke (Stanford University)
"H+-coupled gating in CLC channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Group Photo / Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ligand-gated Channels |
7:30 pm - 7:45 pm | Discussion Leader: Steven Sine (Mayo Clinic) |
7:45 pm - 8:10 pm | Cecilia Bouzat (Universidad Nacional del Sur-Consejo Nacional de Investigaciones Científicas y Técnicas)
"Gating and Desensitization in Homomeric Cys-loop Receptors: Role of the Binding-Pore Interface" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Kenton Swartz (NIH)
"Gating the pore of P2X receptor channels" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Bill Zagotta (University of Washington)
"Molecular Mechanisms for regulation of ion channels by cyclic nucleotides" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TRPs and CRACs |
9:00 am - 9:10 am | Discussion Leader: Miguel A. Valverde (Universitaet Pompeu Fabra) |
9:10 am - 9:45 am | Richard Lewis (Stanford University)
"A molecular mechanism for CRAC channel activation" |
9:45 am - 9:55 am | Discussion |
9:55 am - 10:30 am | Shmuel Muallem (University of Texas, Southwestern)
"Gating of TRPC and Orai channels by STIM1" |
10:30 am - 10:40 am | Discussion |
10:40 am | Coffee Break |
11:10 am - 11:40 am | Ardem Patapoutian (Scripps)
"ThermoTRPs as sensors of temperature and pain" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Feng Qin (SUNY
Buffalo)
"Phosphoinositides and Adaptation of Pain Receptors" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Biological Roles |
7:30 pm - 7:45 pm | Discussion Leader: Lily Jan (UCSF) |
7:45 pm - 8:10 pm | Dejian Ren (University of Pennsylvania)
"NALCN channel function" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Richard Tsien (Stanford University)
"Local Ca channel-CaM kinase cross-talk and its role in signaling to the nucleus" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Lori Isom (University of Michigan)
"Sodium channel β subunits regulate electrical excitability through channel modulation and cell adhesion" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structure |
9:00 am - 9:10 am | Discussion Leader: Francisco Bezanilla (University of Chicago) |
9:10 am - 9:40 am | Eric Gonzales (OHSU)
"Structure and mechanism of acid sensing ion channels" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:20 am | Raimond Dutzler (University of Zurich)
"X-ray structure of a prokaryotic pentameric ligand gated ion channel" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Youxing Jiang (University of Texas, Southwestern)
"Structural study of non-selective tetrameric cation channel" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | Mark Mayer (NIH)
"Structural analysis of allosteric ion binding sites in glutamate receptor ion channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Gating and Permeation |
7:30 pm - 7:55 pm | Discussion Leader: Eduardo Perozo (University of Chicago)
"Structural basis for activation and inactivation gating in KcsA" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:25 pm | Ehud Isacoff (UC Berkeley)
"Voltage gating variations" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Crina Nimigean (Cornell University)
"Molecular mechanism of pH sensing in KcsA potassium channels" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Poster Presentation: Robert French (University of Calgary)
"Selectivity of the bacterial sodium channel, NaChBac, studied by experiment and simulation" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Poster Presentation: Jorge Contreras (NIH)
"Voltage drop along the pore of cation channels: from theory to experimental evidence" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | Channelopathies |
9:00 am - 9:25 am | Discussion Leader: Frances Ashcroft (Oxford University)
"KATP channel mutations and neonatal diabetes: of men and mice" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Steve Cannon (University of Texas, Southwestern)
"An anomalous gating pore resulting from S4 mutations contributes to periodic paralysis" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Mark Baker (Barts and The London School of Medicine)
"Human Na+ channel mutations and insights into pain mechanisms" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Jim Maylie (OHSU)
"Cellular physiology of episodic ataxia type 1 (EA1) induced by mutations in the delayed rectifier potassium channel, Kv1.1" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Stanislav Sokolov (University of Washington)
"Sodium Channel Gating and Neurological Disease" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lipids and Channels |
7:30 pm - 7:40 pm | Discussion Leader: Ching Kung (University of Wisconsin) |
7:40 pm - 8:05 pm | Don Hilgemann (University of Texas, Southwestern) "PIP2 & the Regulation of Membrane and Membrane Transporter Turnover" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Zhe Lu (University of Pennsylvania)
"Ion channel function and membrane lipids" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Breaking News: Eric Honore (IPMC-CNRS)
"Regulation of mechano-gated K2P channels by lipids" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Breaking News: Stephen Long (Memorial-Sloan Kettering Cancer Center)
"Crystal structure of a voltage-dependent potassium channel in a lipid membrane-like environment" |
9:25 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |