SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 7:40 pm | Chair Welcome: Merritt Maduke |
7:40 pm - 9:30 pm | THE CHANNEL/TRANSPORTER BOUNDARY |
| Discussion Leader: Chris Miller (Brandeis University, HHMI) |
7:40 pm - 8:05 pm | Laszlo Csanady (Semmelweis University, Hungary) "Peaked distribution of CFTR Cl- channel burst durations reveals a highly non-equilibrium gating cycle" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Isaiah Arkin (The Hebrew University, Israel) "Ion and drug specificity in a H+ triggered pump and transporter" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Michael Pusch (Istituto di Biofisica, Genova, Italy) "ClC-5, a human nucleotide regulated Cl(-)/H(+) exchanger" |
9:15 pm - 9:25 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LIPIDS AND CHANNELS |
| Discussion Leader: Kenton Swartz (National Institutes of Health, NINDS) |
9:00 am - 9:25 am | Anthony Lee (University of Southampton) "How lipids affect ion channel function" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Paul Blount (University of Texas Southwestern Medical School) "MscL: influences of detergents on oligomerization and of lipid-interactions on gating" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Sharona Gordon (University of Washington) "Membrane Regulation of TRPV1 Ion Channels" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Mounir Tarek (Universite-Henri Poincare) "Gating of Kv channels and the surrounding lipids. Insights from molecular
dynamics simulations" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Ann Rittenhouse (University of Massachusetts Medical School) "Regulation of Voltage-gated Ca2+ Channel Activity by Palmitoylation: A Fatty Acid Tale" |
12:15 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GATING AND CONFORMATIONAL DYNAMICS I |
| Discussion Leader: Clay Armstrong (University of Pennsylvania) |
7:30 pm - 8:00 pm | Rod MacKinnon (The Rockefeller University, HHMI) "Gating in K+ Channels" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ming Zhou (Columbia University) "Crystal structure of a bacterial potassium ion transporter TrkH: mechanisms of selectivity and gating" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Simon Bernèche (University of Basel) "Gating mechanisms in the selectivity filter of K+ channels" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Carlos Villalba-Galea (Virginia Commonwealth University) "Modular Nature of the Main Domains in Voltage Sensitive Phosphatases" |
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | PHYSIOLOGICAL FUNCTIONS |
| Discussion Leader: Diane Papazian (University of California, Los Angeles) |
9:00 am - 9:30 am | John Adelman (Vollum Institute, Oregon Health Sciences University) "SK channels: A story of synaptic serendipity" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Mark Nelson (University of Vermont) "Functional coupling of astrocytic BK channels to arteriolar smooth muscle Kir channels in neurovascular coupling" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Bruce Bean (Harvard University) "Drug delivery through large-pore channels" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Ivy Dick (Johns Hopkins University) "Distinct Inactivation Defects of Different Mutant Calcium Channels underlying Timothy Syndrome" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Terry Dean, Jr (University of Pennsylvania) "Shaking the Sleep Right Out of You" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Rebecca Clark (University of Oxford) "A KATP channel mutation causing neonatal diabetes and muscle dysfunction" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | REGULATORY SUBUNITS AND MODULATORS OF ION CHANNELS |
| Discussion Leader: Carol Deutsch (University of Pennsylvania) |
7:30 pm - 8:00 pm | Henry Colecraft (Columbia University) "Regulation of CaV channels by auxiliary beta subunits" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Steve Traynelis (Emory University) "Control of NMDA receptor function by modulators" |
8:40 pm - 5:50 pm | Discussion |
8:50 pm - 9:20 pm | Bill Kobertz (University of Massachusetts Medical School) "Co- versus post-translational glycosylation of K+ channel regulatory subunits: implications for disease" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | MECHANO/SENSORY MECHANISMS |
| Discussion Leader: Anita Zimmerman (Brown University) |
9:00 am - 9:30 am | Rachelle Gaudet (Harvard University) "Sense and Sensitivity: Molecular Insights into Temperature Sensation" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Jie Zheng (University of California, Davis) "Heat activation of thermoTRP channels" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:05 am | Scott Ramsey (Virginia Commonwealth University) "Voltage- and temperature-dependent activation of TRPV3 channels is potentiated by receptor-mediated PI94,5)P2 hydrolysis" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Miriam Goodman (Stanford University) "Sensory Mechanotransduction Channels Responsible for Touch and Mechanonociception in C. elegans" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Julio F. Cordero-Morales (University of California San Francisco) "Molecular Basis of Infrared Detection by Snakes" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrea Brueggmann (Nanion Technologies) "Electrophysiological Characterization of Ion channels in Lysosomes" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GATING AND CONFORMATIONAL DYNAMICS II |
| Discussion Leader: Gary Yellen (Harvard University) |
7:30 pm - 8:00 pm | Da-neng Wang (New York University) "Structural basis of the ion selectivity and gating mechanism of an organic-ion channel FocA" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Steve Siegelbaum (Columbia University, HHMI) "Structure of a bacterial homolog of the SLAC1 Anion Channel in plant stomata" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Baron Chanda (University of Wisconsin) "Voltage-dependent gating and modulation in sodium channels" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Brad Rothberg (Temple University) "Conformational dynamics of a K+ channel RCK domain analyzed by NMR spectroscopy" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
9:00 am - 12:30 pm | LIGAND-DEPENDENT GATING |
| Discussion Leader: David Weiss (University of Texas, San Antonio) |
9:00 am - 9:25 am | Lucia Sivilotti (University College London) "Single channel insights on the activation mechanism of glycine receptors" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Cynthia Czajkowski (University of Wisconsin) "Structural mechanisms underlying GABA-A receptor activation" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Pierre Paoletti (Ecole Normale Superieure) "How clamshell-like domains control NMDA receptor activity" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Eric Gouaux (Oregon Health Sciences University, HHMI) "Architecture, symmetry and mechanism of ionotropic glutamate receptors" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | David Stroebel (Ecole Normale Superieure) "Oligomeric organization of NMDA receptor" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Mufeng Li (National Institutes of Health, NINDS) "Pore-opening mechanism in trimeric P2X receptor channels" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Ca-DEPENDENDENT REGULATION |
| Discussion Leader: David Yue (Johns Hopkins University) |
7:30 pm - 8:00 pm | Haoxing Xu (University of Michigan) "TRPML Ca2+ Release Channels in the Endolysosome" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Dan Minor (University of California San Francisco) "Structural insights into voltage-gated calcium channel modulation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Kevin Foskett (University of Pennsylvania) "Voltage- and Ca2+- dependent gating of CALHM1" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |