SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 7:40 pm | Chair Welcome: Bill Kobertz |
7:40 pm - 9:30 pm | Data Blitz & Cation Channels |
| Discussion Leader: Henry Colecraft (Columbia University Medical Center) |
7:40 pm - 8:15 pm | Data Blitz |
| Rapid-fire Presentations by Post-docs & Graduate Students |
8:20 pm - 8:45 pm | Paul DeCaen (Harvard Medical School)
"The Structure of NaVRh and Ion Selectivity"
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8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | David Yue (John Hopkins University School of Medicine)
"Calcium channel modulation involves calmodulin on the move"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | Ligand-Dependent Gating |
| Discussion Leader: Francis Ashcroft (University of Oxford) |
9:00 am - 9:25 am | Gabriela Popescu (University at Buffalo Medical School)
"NMDA Receptor Gating: Kinetics and Mechanism"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Mark Mayer (NIH, NICHD)
"Structure and assembly of heteromeric kainate receptors"
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10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | David MacLean (University of Texas, Houston Medical School)
"Conformational Dynamics in Ionotropic Glutamate Receptors"
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11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Michael Francis (UMass Medical School)
"Genetic analysis of a simple neural circuit using ionotropic AChR gating mutants"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Harley Kurata (University of British Columbia)
"Transduction and catalysis of ligand-dependent gating in KATP channels" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrew Plested (Leibniz Institüt für Molekulare Pharmakologie, Berlin, Germany)
"Glutamate Receptors Rock!" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Protons and Anions |
| Discussion Leader: Michael Pusch (Istituto di Biofisica, Genova, Italy) |
7:30 pm - 8:00 pm | Emily Liman (University of Southern California)
"Proton Channels in Taste Transduction"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Merritt Maduke (Stanford University School of Medicine)
"CLC Channels and Antiporters"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Yuriy Kirichok (UCSF)
"How Brown Fat Makes Heat: Mechanism of Thermogenic Proton Leak across the Inner Mitochondrial Membrane"
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9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Sodium Channels |
9:00 am - 9:05 am | Discussion Leader: Dick Horn (Thomas Jefferson University) |
9:05 am - 9:30 am | Todd Scheuer (University of Washington)
"Structure and Function of Voltage-gated Sodium Channels at Atomic Resolution"
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9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Cecilia Canessa (Yale University)
"ASIC1 Channels Some Aspects of Structure-Function, but not certain yet"
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10:05 am - 10:15 am | Discussion |
10:15 am | Coffee Break |
10:45 am - 11:10 am | Ted Cummins (Indiana University School of Medicine)
"Harnessing Gating Pore Currents to Explore the Pharmacology of Voltage-gated Sodium Channels"
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11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Bonnie Wallace (University of London, Birkbeck College)
"The Open Conformation of a Voltage-Gated Sodium Channel"
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11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Lori Isom (University of Michigan Medical School)
"Role of sodium channel beta 1 subunits in inherited pediatric epilepsy" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Gating (Other) |
| Discussion Leader: Chris Miller (Brandeis University, HHMI) |
7:30 pm - 8:00 pm | Chris Ahern (University of British Columbia)
"Taking a Synthetic Approach to Channel Inactivation Mechanisms"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Eduardo Perozo (University of Chicago)
"Structural rearrangements in Voltage Sensing Domains" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Tom Middendorf (University of Texas at Austin)
"Calcium-activated Potassium Channels" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Permeation, Dynamics and Inactivation |
| Discussion Leader: Clay Armstrong (University of Pennsylvania) |
9:00 am - 9:25 am | Benoît Roux (University of Chicago)
"Recovery from slow inactivation" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Crina Nimigean (Weill Cornell Medical College)
"Inactivation Gate Location in MthK Potassium Channels" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:35 am - 11:00 am | Wonpil Im (University of Kansas)
"Ion Channel Brownian Dynamics: Approximate, Yet Still Useful Approach"
|
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Tzyh-Chang Hwang (University of Missouri-Columbia)
"Non-integral stoichiometry in CFTR gating: Seeing is believing!" |
11:25 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Vera Moiseenkova-Bell (Case Western Reserve University)
"Structural insights into the dynamics of the TRPA1 activation mechanism" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Randy Stockbridge (Brandeis University)
"Fluoride transport in a strange subclass of CLC's" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Morten Jensen (DE Shaw Research LLC)
"A mechanistic model of voltage-gating in potassium channels based on long-timescale simulations"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Drug Targets |
| Discussion Leader: Andrea Brüggemann (Nanion Technologies) |
7:30 pm - 8:00 pm | Steve Brohawn (Rockefeller University)
"Structural and Functional Studies of the Lipid- and Mechano-sensitive K2P TRAAK"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Gail Robertson (University of Wisconsin School of Medicine)
"Composition and Gating in hERG and Related Channels"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Steve Hess (Evotec)
"P2X3 and P2X2/3 Channel Drug Discovery"
|
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Potassium Channels |
| Discussion Leader: Cathy Morris (Ottawa Hospital Research Institute) |
9:00 am - 9:25 am | Nicole Schmitt (University of Copenhagen)
"The Cardiac IKs Complex and Molecular Determinants of its Localization"
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9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Paul Slesinger (The Salk Institute for Biological Studies)
"Gating of GIRK Channels: The Trifecta of G proteins, Alcohol and PIP2"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Blanche Schwappach (University of Göttingen Medical School)
"Electrical Fine Tuning of Cardiac Myocytes by Differential Cell Surface Expression of Ion Channels"
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11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Stephen Tucker (University of Oxford)
"Mechanisms of Kir Channel Gating"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Anna Moroni (University of Milan, Italy)
"How to make a voltage-gated ion channel" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Anastasios Tzingounis (University of Connecticut)
"Mapping SK channels in Living Neurons using Single Molecule AFM" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mixed Calcium Signals |
| Discussion Leader: Daniel Minor (UCSF) |
7:30 pm - 8:00 pm | Eitan Reuveny (Weizmann Institute of Science)
"SARAF Inactivates the Store Operated Calcium Entry Machinery to Prevent Excess Calcium Refilling"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Anna Greka (Harvard Medical School)
"TRPCs and Calcium Signaling in Glomerular Podocytes: New Targets for Kidney Disease?"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Ilya Bezprozvanny (UT Southwestern Medical Center)
"Presenilins Function as ER Calcium Leak Channels - Implications for Alzheimer's Disease Pathogenesis"
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9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |