SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Poster Presentations / New Channels |
| Discussion Leader: Carol Deutsch (University of Pennsylvania) |
7:40 pm - 8:20 pm | Poster Previews I |
| Rapid-Fire Presentations by Post-Docs and Graduate Students |
8.20 pm - 8:45 pm | David Clapham (Harvard U.)
"Ion Channels in Cilia and What They Do" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Stephen Long (Memorial Sloan Kettering Cancer Center)
"Structural and Functional Analysis of a Eukaryotic Anion Channel" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Channel Childhood: Trafficking and Regulators |
| Discussion Leader: Fred Sigworth (Yale University) |
9:00 am - 9:25 am | Lily Jan (UCSF)
"Adolescent Channels in the TMEM16 Family"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Chris Lingle (Washington University)
"BK Channel Regulation by Auxiliary Subunits"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:30 am - 10:55 am | Show-Ling Shyng (OHSU)
"Pharmacological Chaperoning of Trafficking-Impaired KATP Channels"
|
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Paul Welling (U. Maryland)
"Clathrin Adaptors Bringeth and Taketh Kir Channels"
|
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Indra Schroeder (Technical University of Darmst, Germany)
"Viral Potassium Channels as a Model System for Structure-Function Relations"
|
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:30 pm | Poster Previews II |
| Rapid-Fire Presentations by Post-Docs and Graduate Students |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Channel Adolescence: New Partners |
| Discussion Leader: Bill Kobertz (University of Massachusetts) |
7:30 pm - 7:55 pm | Bernd Fakler (University of Freiburg)
"Native AMPA-Receptor Channels - Insights from Functional Proteomics"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Geoff Abbott (UC Irvine)
"Channel-Transporter Interactions"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Randy Stockbridge (Brandeis University)
"Dual Topology of a Microbial Fluoride Channel"
|
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Heather Pinkett (University of Pennsylvania)
"Implications in the Classification of Bacterial ABC Transporters"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Channel Life I: Gating and Permeating |
| Discussion Leader: William Zagotta (University of Washington) |
9:00 am - 9:25 am | Teresa Giraldez (ULL, Spain)
"BK Channel Gating-Ring Motions During Activation"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Simon Berneche (University of Basel, Switzerland)
"Mechanisms of Activation and Inactivation at the Selectivity Filter of K Channels"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Steve Lockless (Texas A&M University)
"Equilibrium Ion Binding Properties of Tetrameric Cation Channels"
|
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Youxing Jiang (UTSW)
"On the Origin of Ion Selectivity in K Channels""
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Tom DeCoursey (Rush University)
"Voltage-Gated Proton Channels: VSDs with Attitude"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Channel Life II: Membranes and Toxins |
| Discussion Leader: TBA |
7:30 pm - 7:55 pm | Eric Lingueglia (University of Nice, France)
"Peptide Toxins to Explore the Role of Acid-Sensing Ion Channels in Pain"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Mounir Tarek (University of Lorraine, France)
"On Activation and Lipid Modulation of Kv Channels Gating from Molecular Dynamics Simulations"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Qiuxing Jiang (UTSW)
"Lipid-Dependent Gating Effects on Voltage-Gated Potassium Channels"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Elwin van der Cruijsen (Utrecht University, Holland)
"Dissecting Protein Structure and Dynamics in Membranes During the Gating Cycle of a Potassium Channel"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Channel Lifestyle I: Drugs and Para(pharm)ernalia |
| Discussion Leader: Kenton Swartz (NIH) |
9:00 am - 9:25 am | Owen McManus (Essen Biosciences)
"Ion Channel Therapeutics: New Ideas from Both Sides of the Fence"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Cindy Czajkowski (University of Wisconsin)
"Pentameric Ligand Gated Ion Channels: Uncovering the Motions Underlying Ligand-Driven Conformational Transitions"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | David Fedida (University of BC, Canada)
"Ion Channel Blockers for Therapeutics: From Theory into Practice, Today and Tomorrow"
|
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Jerod Denton (Vanderbilt University)
"Small-Molecule Probes of Kir Channel Structure, Function, and Druggability"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Gareth Young (Pfizer Neusentis, UK)
"Characterizing Human Stem Cell Derived Sensory Neurons at the Single Cell Level Reveals Their Ion Channel Expression and Utility in Pain Research"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Len Kaczmarek (Yale University)
"Human Gain-of-Function Slack Potassium Channel Mutations Alter Channel Cooperativity and Signaling Protein Interactions"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Channel Lifestyle II: Channels in Specialized Places |
| Discussion Leader: Bertil Hille (University of Washington) |
7:30 pm - 7:55 pm | Dejian Ren (University of Pennsylvania)
"Lysosomal ATP-Sensitive TPC Na+ Channels and Their Regulation"
|
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Ellen Lumpkin (Columbia University)
"Mechanotransduction Channels in Epidermal Cells"
|
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Ardem Patapoutian (Scripps Inst.)
"How Do You Feel? Ion Channels That Sense Mechanical Force"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Monica Sala-Rabanal (Washington University in Saint Louis)
"Secreted CLCA1 Modulates Anoctamin1/TMEM16A to Activate Ca2+-Dependent Chloride Currents in Human Cells"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Channel Surgery: Engineering, Modification and New Methods |
| Discussion Leader: Gary Yellen (Harvard University) |
9:00 am - 9:25 am | Pancho Bezanilla (University of Chicago)
"Down the Path of the Sensor Charges!"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Katie Henzler-Wildman (Washington University)
"(Non)selectivity in Transporters and Channels: A Resonant Perspective"
|
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Peter Hegemann (Humboldt University, Germany)
"Conversion of Channelrhodopsin into a Light-Gated Chloride Channel"
|
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | David Drew (Stockholm University, Sweden)
"Tools and Structures to Unravel the Ins and Outs of SLC Transport"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Francis Valiyaveetil (Oregon Health and Sciences University)
"Using Unnatural Mutagenesis to Investigate C-Type Inactivation in K+ Channels"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Zhaozhu Qiu (Scripps Research Inst.)
"SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Channel Infirmity: Channels and Diseases |
| Discussion Leader: Chris Miller (Brandeis University) |
7:30 pm - 7:55 pm | Fran Ashcroft (Oxford University, UK)
"Neonatal Diabetes: A Unique K Channelopathy"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Annette Dolphin (UCL, UK)
"Neuronal Voltage Gated Calcium Channel Trafficking and Neuropathic Pain"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Geoff Pitt (Duke University)
"Voltage-Gated Ca Channel Dysfunction in Non-Excitable Tissues: New Mechanisms for Birth Defects"
|
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |