Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: New Directions in Ion Channel Research |
| Discussion Leader: David Clapham (Harvard Medical School, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:25 pm | Richard Tsien (New York University School of Medicine, USA) "Novel Modes of Information Transfer to Drive Neuronal Plasticity" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:10 pm | David Julius (University of California, San Francisco, USA) "Structural Insights into Pain Sensation" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Thermosensing Through Ion Channels |
| Discussion Leader: Magdalene Moran (Hydra Biosciences, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Jie Zheng (University of California, Davis, USA) "TRPV1 Activation by Vanilloids" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Ramon Latorre (University of Valparaíso, Chile) "Allosterism and Structure in Thermally-Activated
Transient Receptor Potential Channels" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:40 am | Sharona Gordon (University of Washington, USA) "Measuring Confomational Dynamics in TRPV1 Using ncAA and tmFRET" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:15 am | Coffee Break |
11:15 am - 11:40 am | Baron Chanda (University of Wisconsin-Madison, USA) "Hidden
in Plain Sight: A Plausible Mechanism of Temperature-Sensing" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Candice Paulsen (University of California, San Francisco, USA) "Structure of the TRPA1 Ion Channel Suggests Regulatory Mechanisms" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizers: Miriam Goodman (Stanford University, USA) and Sharona Gordon (University of Washington, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure of Ion Channels |
| Discussion Leader: Brad Rothberg (Temple University School of Medicine, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Daniel Minor (University of California, San Francisco, USA) "How Do Channels Respond to Temperature?" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Donald Gill (Pennsylvania State University, USA) "Understanding the STIM-Orai Coupling Interface" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Rachelle Gaudet (Harvard University, USA) "Substrate Selectivity in Nramp-Family Transition Metal Transporters" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Ryan Hibbs (University of Texas Southwestern Medical Center, USA) "Nicotinic Acetylcholine Receptors" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanosensory Ion Channels |
| Discussion Leader: Miriam Goodman (Stanford University, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Bailong Xiao (School of Pharmaceutical Sciences, Tsinghua University, China) "Structural and Functional Characterizations of the Mechanosensitive
Piezo1 Channel" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Jorg Grandl (Duke University, USA) "Mechanism of Activation and Modulation of Piezo
Ion Channels" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Ruhma Syeda (The Scripps Research Institute, USA) "Piezo1 Channels Are Inherently Mechanosensitive" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Slav Bagriantsev (Yale University, USA) "Neuronal Mechanoreception in Tactile Specialist Ducks" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Craig Montell (University of California, Santa Barbara, USA) "The Molecular and Cellular Basis of Gustatory Detection in Drosophila" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Francesco Tombola (University of California, Irvine, USA) "Mechanosensitivity
of the Hv1 Channel" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modulation of Ion Channels |
| Discussion Leader: Ann Rittenhouse (University of Massachusetts Medical School, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Tibor Rohacs (Rutgers New Jersey Medical School, USA) "Regulation of Somatosensory Ion Channels by Phosphoinositides" |
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Bruce Bean (Harvard Medical School, USA) "Endocannabinoid Modulation of Dopamine Neuron Excitability" |
8:30 pm - 8:35 pm | Discussion |
8:35 pm - 9:00 pm | Diomedes Logothetis (Virginia Commonwealth University, USA) "Phosphoinositide and G Protein Regulation of Inwardly Rectifying Potassium Channels" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Bonnie Wallace (Birkbeck, University of London, United Kingdom) "The Complete Crystal Structure of an Activated Open Sodium Channel" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Ion Channels in Concert |
| Discussion Leader: Bertil Hille (University of Washington, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Mark Nelson (University of Vermont, USA) "Ion Channel Networks in the Control of Cerebral Blood Flow" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | Diane Papazian (University of California, Los Angeles, USA) "Ion Channel Gating and Infant-Onset Neurological Diseases" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Polina Lishko (University of California, Berkeley, USA) "Steroids, Endocannabinoids and Ion Channels" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Andrea Meredith (University of Maryland School of Medicine, USA) "Molecular Mechanisms of Circadian Variation in BK Current Properties" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Mark Shapiro (University of Texas Health Science Center at San Antonio, USA) "Clustering
of Diverse Channels and Receptors in Sensory Neurons Revealed at the Single-Molecule Level by Super-Resolution Microscopy" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Assembly and Trafficking of Ion Channels |
| Discussion Leader: Carol Deutsch (University of Pennsylvania, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 8:00 pm | Gail Robertson (University of Wisconsin-Madison, USA) "Co-Translational Association of mRNA Encoding Heteromeric Ion Channels" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Paul Slesinger (Icahn School of Medicine at Mount Sinai, USA) "Psychostimulants Put GIRK Channels on the Move" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Thomas Baukrowitz (University of Kiel, Germany) "A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Eunyong Park (Rockefeller University, USA) "Structure and Mechanism of CLC Chloride Channels" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Engineering Ion Channels |
| Discussion Leader: Chris Ahern (University of Iowa, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Ehud Isacoff (University of California, Berkeley, USA) "Gating mGluRs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:05 am | William Kobertz (University of Massachusetts Medical School, USA) "Fluorescent Visualization of Cellular Efflux" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:30 am | Hongkang Zhang (Harvard University, USA) "Optical Electrophysiology for Probing Function and Pharmacology of Voltage-Gated Ion Channels" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:00 am | Coffee Break |
11:00 am - 11:25 am | Richard Kramer (University of California, Berkeley, USA) "Chemical Photosensitization of Voltage-Gated Ion Channels as a Strategy
for Restoring Vision to the Blind" |
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Andrew Plested (Leibniz Institute for Molecular Pharmacology, Germany) "Glutamate Receptors: Lights, Camera, Action" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Jian Payandeh (Genentech, Inc., USA) "How to Trap a Voltage-Sensor: Insights from Engineering Nav1.7-Selective
Inhibition" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Ion Channels / New Functions for Ion Channels |
| Discussion Leader: Andrea Brueggemann (Nanion Technologies, Germany) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:50 pm | Willem Laursen (Yale University, USA) "Diminished Heat Sensitivity of TRPV1 Supports Heat Tolerance in Ground Squirrels and Camels" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Ian Ramsey (Virginia Commonwealth University, USA) "Hv1 Proton Channel Gating" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Kevin Foskett (Perelman School of Medicine, University of Pennsylvania, USA) "CALHM Ion Channels in Taste Perception" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Christopher Miller (Brandeis University, USA) "A Weird Ion Channel for a Weird Ion" |
9:15 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |