Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Ion Channels in Excitable Cells
Discussion Leader: Teresa Giraldez (University of La Laguna, Spain)
7:40 pm - 8:25 pm
Sudha Chakrapani (Case Western Reserve University, United States)
"Mechanisms of Gating and Drug Modulation in Pentameric Ligand-Gated Channels"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Eduardo Perozo (University of Chicago, United States)
"Electromechanical Coupling in Non-Domain Swapped K+ Channels"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Anion Channels in Health and Disease
Discussion Leaders: Alexandria Miller (HHMI/Janelia Research Campus, United States)
9:00 am - 9:20 am
Anne Carlson (University of Pittsburgh, United States)
"TMEM16A and Fertilization in the African Clawed Frog, Xenopus laevis "
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Zhaozhu Qiu (Johns Hopkins University, United States)
"Molecular Identification and Function of a Proton-Activated Chloride (PAC) Channel"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Stephen Long (Memorial Sloan Kettering Cancer Center, United States)
"Gating Choreography and Mechanism of the Human Proton-Activated Chloride Channel ASOR (PAC)”"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Colleen Noviello (UT Southwestern Medical Center, Dallas, TX, USA, United States)
"Structural Mechanisms underlying Autoimmune GABAA Encephalitis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Merritt Maduke (Stanford University, United States)
"CLC Channels and Transporters"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Alessio Accardi (Weill Cornell Medicine, United States)
"TMEM16 Scramblases Thin the Membrane to Enable Lipid Scrambling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Cynthia Czajkowski (University of Wisconsin-Madison, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Channel Pharmacology and Channelopathies
Discussion Leader: Valeria Vasquez (University of Tennessee Health Science Center, United States)
7:30 pm - 7:50 pm
Paul Slesinger (Icahn School of Medicine at Mount Sinai, United States)
"Leveraging Structures of GIRK Channels for Targeting Diseases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Andrea Bruggemann (Nanion Technologies, Germany)
"Mechanical and Pharmacological Activation of Piezo1 Channels Characterized by High Throughput Electrophysiology"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Stephen Tucker (University of Oxford, United Kingdom)
"Development Delay with Sleep Apnea - a Novel K2P Channelopathy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Henry Colecraft (Columbia University, United States)
"Targeting Ion Channel Ubiquitination for Therapeutics"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Dynamic Approaches to Bridge Structure and Function
Discussion Leader: William Kobertz (University of Massachusetts Medical School, United States)
9:00 am - 9:20 am
Chris Ahern (University of Iowa, United States)
"Breaking the Gate in Voltage-Gated Ion Channels with Main-Chain Mutagenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Marc Kschonsak (Genentech, United States)
"The NALCN Leak Channel: Broken Sensors, Closed Gates and a Big Bicycle"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Samuel Usher (University of Copenhagen, Denmark)
"Identifying Physiological Regulators of the Sodium Leak Current"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Rebecca Howard (Stockholm University, Sweden)
"Convergent Mechanisms from Simulations and Structure-Function Studies of Model Pentameric Ligand-gated Ion Channels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Wayland Cheng (Washington University, United States)
"Nanodisc Scaffold and Size Alters the Structure of a Pentameric Ligand-gated Ion Channel"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Marcel Goldschen-Ohm (University of Texas at Austin, Dept. of Neuroscience, United States)
"Ligand-Gating: An Eye on the Stimulus"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Sebastian Brauchi (Universidad Austral de Chile , Chile)
"Imaging Organellar Electrical Activity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Simon Scheuring (Weill Cornell Medicine, United States)
"Conformational Dynamics of Unlabelled Channels and Transporter at the Single Molecule Level by High-Speed Atomic Force Microscopy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Calcium Channel Complexes and Cell Signaling
Discussion Leader: Ivy Dick (University of Maryland School of Medicine, United States)
7:30 pm - 7:50 pm
Amy Lee (University of Texas-Austin, United States)
"Probing the Presynaptic Functions of Cav1.4 Channels in the Retina"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Claudia Moreno (University of Washington, United States)
"Effects of Aging in the Function of Voltage-Gated Calcium Channels"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Filip Van Petegem (University of British Columbia, Canada)
"Structural and Functional Investigation of Mechanical Coupling between L-type Calcium Channels and Ryanodine Receptors"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jean-Ju Chung (Yale School of Medicine, United States)
"3D Structure and in situ Arrangements of a Mammalian CatSper Channel"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Voltage-Sensing and Gating, Plus Large-Pore Channels
Discussion Leader: Baron Chanda (Washington University in St. Louis, United States)
9:00 am - 9:20 am
Crina Nimigean (Weill Cornell Medicine, United States)
"Mechanism of Ligand and Lipid Gating in Potassium Channels"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Kenton Swartz (National Institutes of Health, United States)
"Structure of the Shaker Kv channel and Mechanism of Slow C-type Inactivation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Francis Valiyaveetil (Oregon Health and Science University, United States)
"Gating at the Selectivity Filter of Potassium Channels"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Shizhen Wang (University of Missouri-Kansas City, United States)
"Ligand and Voltage Gating in the Human Proton Channel hHv1"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Peng Yuan (Washington University School of Medicine, United States)
"Structural Insights into Pannexin Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Juan Du (Van Andel Institute, United States)
"Structural Basis for ATP Release in Purinergic Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cardiac Ion Channels and their Modulation
Discussion Leader: David Jones (University of Michigan Medical School, United States)
7:30 pm - 7:50 pm
Gail Robertson (University of Wisconsin-Madison, United States)
"Cotranslational Regulation of Membrane Excitability"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jianmin Cui (Washington University in St. Louis, United States)
"Finding IKs-specific Modulators with a Rational Target Selection Approach"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Bernard Attali (Tel Aviv University, Israel)
"A Unique Mechanism of Inactivation Gating of KCNQ1 and its Modulation by PIP2 and Calmodulin"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Jenna Lin (Washington University in St. Louis, United States)
"C-Terminal Domain Influences the Gating Polarity of CNBD Family of Ion Channels"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Peter Larsson (University of Miami, United States)
"Modulation of Cardiac Potassium Channels"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
TRP and Other Sensory Channels
Discussion Leaders: Alexandria Miller (HHMI/Janelia Research Campus, United States) and Valeria Kalienkova (University of Groningen, The Netherlands)
9:00 am - 9:20 am
Lejla Zubcevic (University of Kansas Medical Center, United States)
"The Role of Cytoplasmic Domains in TRP Channel Gating"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Elena Gracheva (Yale University School of Medicine, United States)
"How Do Hibernators Deal with Temperature Extremes?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
Vera Moiseenkova-Bell (University of Pennsylvania, United States)
"Systems Pharmacology and Translational Therapeutics"
11:00 am - 11:15 am
Discussion
11:15 am - 11:25 am
Hanbin Jeong (OHSU, United States)
"Structure of the Mechanosensory TMC-1 Complex from C. elegans"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Julio Cordero-Morales (University of Tennessee, United States)
"The Role of PIEZO2 in a Neurogenetic Disorder"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Swetha Murthy (Vollum Institute, OHSU, United States)
"Deciphering Touch Sensation in Carnivorous Plants"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glutamate Receptors from Structure to Synapse
Discussion Leader: Vasanthi Jayaraman (University of Texas Health Science Center at Houston, United States)
7:30 pm - 7:50 pm
Hiro Furukawa (Cold Spring Harbor Laboratory, United States)
"Structural Neuropharmacology of NMDA Receptors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Gabriela Popescu (University at Buffalo, SUNY, United States)
"Mechanisms for Controlling NMDA Receptor Calcium Output"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Ingo Greger (Medical Research Council, United Kingdom)
"Activation and Modulation of AMPA Receptor Complexes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Andrew Plested (Leibniz Institute for Molecular Pharmacology, Germany)
"Slow AMPA Receptors"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure