Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Rigor and Transparency
Discussion Leader: Swetha Murthy (The Scripps Research Institute / Howard Hughes Medical Institute, USA)
3:45 pm - 4:15 pm
Shai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Rigor and Transparency"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Ion Permeation and Channel Gating / Dynamic Selectivity Filters
Discussion Leaders: Wojciech Kopec (Max Planck Institute for Biophysical Chemistry, Germany) and Valeriia Kalienkova (University of Zurich, Switzerland)
7:30 pm - 7:35 pm
Introduction by Discussion Leader: Ion Permeation and Channel Gating
7:35 pm - 7:50 pm
Dawid Deneka (University of Zurich, Switzerland)
"Structure of a Volume-Regulated Anion Channel of the LRRC8 Family"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
Taylor Hughes (University of Pennsylvania, USA)
"Mechanism of TRPV5 Modulation and Gating as Revealed by Cryo-EM"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Alexandria Miller (Memorial Sloan Kettering Cancer Center, USA)
"Cryo-EM Structures Reveal the Mechanism of Bestrophin Ca2+ Dependent Gating"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:35 pm
Introduction by Discussion Leader: Dynamic Selectivity Filters
8:35 pm - 8:50 pm
Andres Jara-Oseguera (National Institute of Neurological Disorders and Stroke, NIH, USA)
"The Role of the Selectivity Filter in TRPV1 Channel Gating"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Kitty Hendriks (Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Germany)
"A Single NaK Channel Conformation Is Not Enough for Non-Selective Ion Conduction"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Oliver Rauh (Technische Universität Darmstadt, Germany)
"Outward Rectification in a Viral Potassium Channel Is Based on Ion Depletion of the Selectivity Filter"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Ligand-Induced Gating / Allosteric Coupling
Discussion Leaders: Anton Sinitskiy (Stanford University, USA) and John Cowgill (University of Wisconsin-Madison, USA)
9:00 am - 9:05 am
Introduction by Discussion Leader: Ligand-Induced Gating
9:05 am - 9:15 am
Andrea Saponaro (University of Milan, Italy)
"Structure-Guided Design of Synthetic Peptides for Orthogonal Control of HCN Channels"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
Jelena Baranovic (Leibniz Institute for Molecular Pharmacology, Germany)
"Auxiliary Subunits Keep AMPA Receptors Compact During Activation and Desensitization"
9:30 am - 9:35 am
Discussion
9:35 am - 9:50 am
Michael Puljung (University of Oxford, United Kingdom)
"Using FRET to Disentangle Nucleotide Binding Effects on KATP"
9:50 am - 9:55 am
Discussion
9:55 am - 10:00 am
Introduction by Discussion Leader: Allosteric Coupling
10:00 am - 10:10 am
Panpan Hou (Washington University in St. Louis, USA)
"Molecular Mechanisms of VSD-Pore Coupling of IKs Channels"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Joao Carvalho-de-Souza (The University of Chicago, USA)
"Key Residues in the Interface Between Voltage Sensor and Pore Domain in Shaker"
10:25 am - 10:30 am
Discussion
10:30 am - 10:45 am
Willow Coyote-Maestas (University of Minnesota, USA)
"Mapping and Harnessing Allosteric Potential in Ion Channels Through Saturated Domain Insertion Profiling"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Activating Your Career: Pathways and Mechanisms
Discussion Leader: Claudia Alvarez-Baron (University of Wisconsin-Madison, USA)
1:30 pm - 2:30 pm
Panel Discussion
Activating Your Career: Pathways and Mechanisms
Lucie Delemotte (Science for Life Laboratory, Sweden)
Shai Silberberg (National Institute of Neurological Disorders and Stroke, NIH, USA)
Wendy Wu (U.S. Food and Drug Administration, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
