Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Fight the Invader: Ion Channels in Host Defense
Discussion Leader: Hanxiong Zhang (Harvard Medical School, United States)
3:45 pm - 4:00 pm
Uday Tak (University of Colorado Boulder, United States)
"Nucleotide-Activated Ion Channels Mediate Antiviral Immunity in Prokaryotes"
4:00 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
Ana Fernandez-Mariño (NINDS-NIH, United States)
"Structures of the T Cell Potassium Channel Kv1.3 with Immunoglobulin Modulators"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
It’s Electric: Ion Channels in Excitable Cells
Discussion Leaders: Vinay Kumar Sapuru (Sloan Kettering Institute and Weill Cornell Medicine, United States) and Siyuan Zhao (Rutgers University, United States)
7:30 pm - 7:45 pm
Ewa Sieliwonczyk (University of Antwerp, Belgium)
"In vivo calcium and voltage mapping of the zebrafish heart"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Alicia De la Cruz (University of Miami, United States)
"Human Induce Pluripotent Stem Cell-Derived Cardiomyocyte Model to Study PUFA Analogs as a Potential Treatment of Long QT Syndrome"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Nissi Varghese (University of Connecticut, United States)
"KCNQ2 Gain-of-Function Variants: Are They Acting as Gain-of-Function in Neurons?"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Bridget McVeigh (University of Pennsylvania, United States)
"Subcellular Localization Patterns and Protein-Protein Interaction Networks of Wild-Type Human TRPML1 and Mild and Severe Mucolipidosis Type IV-Causing Mutations"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
James Krieger (Centro Nacional de Biotecnología (CSIC), Spain)
"AMPA Glutamate Receptor Dynamics from New Methods for CryoEM Image Processing Using Zernike Polynomials and Computational Biophysics"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Insane in the Membrane: Lipids, Front and Center / Insane in the Brain: Ion Channels Involved in Neurotransmission
Discussion Leaders: Andy Lam (University of Zurich, Switzerland) and Eric Gibbs (Case Western Reserve University, United States)
9:00 am - 9:15 am
Philipp Schmidpeter (Weill Cornell Medical College, United States)
"Anionic Lipids Unlock the Gate of Pacemaker Channels"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Luis Romero (University of Tennessee Health Science Center, United States)
"A Dietary Fatty Acid Decreases Sensory Neurons Mechanical Excitability by Inhibiting PIEZO2 Channels"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Melanie Arndt (University of Zurich (UZH), Switzerland)
"Structural Basis for the Activation of the Ion Channel and Lipid Scramblase TMEM16F"
10:05 am - 10:15 am
Discussion
10:15 am - 10:30 am
Julia Bleier (University of California, Berkeley, United States)
"GluN2 Subunits Dictate NMDAR Conformational Trajectories"
10:30 am - 10:40 am
Discussion
10:40 am - 10:55 am
Laura Piot ( Institut de Biologie de l'Ecole Normale Supérieure (IBENS), France)
"Crossing the Boundaries: an iGluR that Binds GABA and Regulates Inhibitory Synaptic Transmission"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: The Long and Winding Road: Personal Perspectives on Scientific Careers
Discussion Leaders: Valeria Kalienkova (University of Groningen, The Netherlands) and Alexandria Miller (HHMI/Janelia Research Campus, United States)
1:30 pm - 2:30 pm
Panel Discussion
The Long and Winding Road: Personal Perspectives on Scientific Careers
Andrea Bruggemann (Nanion Technologies, Germany)
Anne Carlson (University of Pittsburgh, United States)
Rebecca Howard (Stockholm University, Sweden)
Kenton Swartz (National Institutes of Health, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
