| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Lectures |
| Discussion Leader: John W. Peters (Montana State University) |
| 7:30 pm - 8:20 pm | Richard H. Holm (Harvard University)
"A Brief Perspective with Applications to Weak Field (Iron-Sulfur) Clusters in Biology" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 9:20 pm | Rolf Thauer (Philipps University Marburg)
"Hydrogenase: 75 years on" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Iron-Sulfur Cluster Biosynthesis |
| Discussion Leader: Dennis R. Dean (Virginia Tech.) |
| 9:00 am - 9:35 am | Elizabeth Craig (University of Wisconsin)
"Evolution of Molecular Chaperone Function in Fe-S Cluster Assembly" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Tracey Rouault (National Institutes of Health)
"The iron-sulfur regulatory switch of mammalian iron regulatory protein 1" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break / Group Photo |
| 11:00 am - 11:35 am | John Golbeck (Pennsylvania State University)
"Regulation of Fe/S Cluster Biogenesis in Cyanobacteria: The Involvement of Rubredoxin and the Suf Regulon in Fe/S Cluster Assembly in Photosystem I" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Michael Johnson (University of Georgia)
"Fe-S cluster Biosynthesis using the NIF and ISC Systems" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Hydrogenase |
| Discussion Leader: Stephen Cramer (University of California at Davis) |
| 7:30 pm - 7:55 pm | Fraser Armstrong (Oxford University)
Dynamic electrochemical studies of how hydrogenases react with or avoid O2, CO and H2S, and implications for technological advances |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Chris Pickett (University of East Anglia)
"Artificial H-clusters: the Role of the 4Fe4S Unit in Redox Modulation of the Chemistry of the Diiron Subsite" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:00 pm | Thomas Rauchfuss (University of Illinois)
"Recent Advances in Structural and Functional Models for the Fe-only Hydrogenases" |
| 9:00 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Robert Szilagyi (Montana State University)
"Hydrogenase: H cluster Electronic Properties and Biosynthesis" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Nitrogenase |
| Discussion Leader: David Lowe (John Innes Centre) |
| 9:00 am - 9:25 am | Lance Seefeldt (Utah State University)
"Elucidating Intermediates in the N2 Reduction Mechanism of Nitrogenase" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Patick Holland (University of Rochester)
"Synthetic Low-Coordinate Iron Complexes as Models for the FeMoco of Nitrogenase" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Akif Tezcan (University of California at San Diego)
"The Role of Multiple Protein-Protein Interaction Sites in Nitrogenase Catalysis" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Barry Rosen (Wayne State University Medical School)
"ArsA: a NifH homologue that detoxifies arsenic" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Matthias Boll (University of Freiburg)
"Dearomatizing Benzene Ring Reductases in Anaerobic Bacteria" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Radical SAM Enzymes |
| Discussion Leader: Joe Jarrett (University of Hawaii) |
| 7:30 pm - 8:00 pm | Catherine Drennan (Massachusetts Institute of Technology)
"Crystallography Studies of AdoMet Radical Enzymes" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Joan Broderick (Montana State University)
"Investigating the Fe-S Cluster in the Ternary PFL-AE/SAM/PFL Complex: Implications for Mechanism" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Squire Booker (Pennsylvania State University)
"Mechanistic Studies on Lipoyl Synthase: Will the Real Intermediates Please Stand Up?" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Iron-Sulfur Cluster Chemistry |
| Discussion Leader: Fraser Armstrong (Oxford University) |
| 9:00 am - 9:35 am | Stephen Lippard (Massachusetts Institute of Technology)
"Nitric Oxide Chemistry of Biologically Relevant Iron Complexes with Sulfur-Donor Ligands" |
| 9:35 am - 9:45 am | Discussion |
| 9:45 am - 10:20 am | Marcetta Darensbourg (Texas A&M)
"Iron Dinitrosyl Complexes: A Reaction Model for Vanin's NO Storage, Transport and Transfer" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:35 am | David Case (Scripps Research Institute)
"Quantum Chemical Studies of Active Sites of Iron-Sulfur Proteins" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:20 pm | Toshiko Ichiye (Georgetown University)
"Tuning and Breaking Synthetic and Protein-bound [4Fe-4S] Clusters" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Biosynthesis of Complex Bridged Iron-Sulfur Assemblies |
| Discussion Leader: Helmut Beinert (University of Wisconsin) |
| 7:30 pm - 7:55 pm | Paul Ludden (University of California at Berkeley)
"NifB-Dependent In Vitro Synthesis of the Iron-Molybdenum Cofactor of Nitrogenase" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Markus Ribbe (University of California at Irvine)
"Nitrogenase: a Paradigm for Metallocluter Assembly" |
| 8:30 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Matthew Posewitz (National Renewable Energy Laboratory)
"Identification of Novel Maturation Proteins Required for [FeFe]-Hydrogenase Activity" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Marc Fontecave (Université Joseph Fourier)
"A complex Iron-Sulfur Protein Machinery for Hydrogenase Maturation" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Other Roles for Iron-Sulfur Proteins and Enzymes |
| Discussion Leader: Rolf Thauer (Philipps University Marburg) |
| 9:00 am - 9:25 am | Juan Fontecilla-Camps (CNRS - Grenoble)
"Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase.and its Interaction with RNA" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Karl Volz (University of Chicago)
"Structure of the Iron Regulatory Protein-1:Ferritin IRE Complex: Insights into Regulated Interconversion and RNA Selectivity" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:45 am | Coffee Break |
| 10:45 am - 11:10 am | Andrew Thompson (University of East Anglia)
"Iron Sulfur Clusters as Oxygen Sensitive Regulators of Bacterial Genes" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:45 am | Vincent Huynh (Emory University)
"Site-Specific Chemistry of the [4Fe-4S] Cluster in Ferredoxin:Thioredoxin Reductase" |
| 11:45 am - 11:55 am | Discussion |
| 11:55 am - 12:20 pm | Sheila David (University of Utah)
"Roles for Fe-S Clusters in Base-Excision Repair" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Environmental and Prebiotic Chemistry |
| Discussion Leader: Trevor Douglas (Montana State University) |
| 7:30 pm - 8:00 pm | Derek Lovley (Univeristy of Massachusetts at Amherst)
"Extracellular electron transfer via Iron-Sulfur Proteins and Other Routes" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Martin Schoonen (Stoney Brook University)
"Minerals as Prebiotic Catalysts and the Transition to Biocatalysts" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Günter Wächtershäuser (Germany)
"From volcanic origins of chemoautotrophic life to bacteria, Archaea and Eukarya" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
