| SUNDAY |
| 2:00 pm | Arrival and Registration |
| 6:00 pm | Dinner |
| 7:30-9:30 pm | Low-coherence imaging |
| Low-coherence and short-pulse light sources provide unique advantages for high-resolution, high-contrast imaging to shallow depths in biological tissues. Optical coherence tomography exploits interferometric ranging with low-coherence sources and has been applied in several clinical studies. New developments in these technologies and in their medical applications will be discussed. |
| Organizer: Brett E. Bouma, Ph.D., Massachusetts General Hospital |
| 7:30-7:55 pm | Guillermo James Tearney M.D., Ph.D., Massachusetts General Hospital
"Clinical Applications of OCT" |
| 7:55-8:20 pm | Johannes De Boer Ph.D., Massachusetts General Hospital
"Polarization Sensitive OCT"
|
| 8:20-8:45 pm | Changhuei Yang, Adam Wax and Michael S. Feld, MIT Spectroscopy Laboratory
"Exploring chaos and fractals in biological cells using low-coherence interferometry" |
| 8:45-9:10 pm | Christoph K. Hitzenberger, Institute of Medical Physics, University of Vienna
"High speed 3D OCT of the human retina" |
| 9:10-9:35 pm | Jerome Mertz, Ecole Superieure de Phys et de Chimie
"Principles and applications of second-harmonic generation microscopy" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | Nanotechnologies for Optical Sensing, Imaging, and Manipulation |
| Advances in nanotechnology have generated a new range of optically-active materials that promise to advance the use of lasers in medicine and biology for sensing, imaging, and manipulation. This session will showcase some of the new nanomaterials, their optical properties, and their potential applications. |
| Organizer: Jennifer West, PhD, Rice University |
| 9:00-9:45 am | Dr. Naomi Halas, Rice University
"Diagnostic and Therapeutic Applications of Metal Nanoshells" |
| 9:45-10:30 am | Dr. Chris Hollars, Lawrence Livermore National Laboratory
"Nanotechnologies for Optical Biosensing" |
| 10:30-11:00 | Coffee Break |
| 11:00-11:45 | Dr. Carolyn Larabell, UC San Francisco
"Measuring cell motility and metastatic potential with quantum dots" |
| 12:30 pm | Lunch |
| 1:30-4:30 pm | Free of all formal activity |
| 4:30-6:00 pm | Career Paths in Biomedical Engineering Symposium |
| 6:00 pm | Dinner |
| 7:30-9:30 pm | Biological Applications of Micro-optical Devices |
| This session explores how novel fabrication and device technologies are enabling a re-interpretation of optical instruments ranging from microscopes to cell sorters on a smaller scale, at a lower cost, or a higher level of sensitivity. The first two presentations highlight the incorporation of micro-electro-mechanical systems (MEMS) and micro-opto-electro-mechanical systems (MOEMS) components into ultra-miniature, high-resolution-imaging endoscope devices. Miniature beam deflectors and micro-optics allow a variety of microscopy techniques, including confocal microscopy and optical-coherence tomography (OCT), to be implemented in devices whose size does not exceed a few millimeters. The third presentation describes microfluidic systems formed by replication molding of elastomers. In this case, miniature valves, pumps, and optics are fabricated by a low-cost process and integrated directly with photodetector arrays to construct robust, inexpensive and efficient cell sorters, spectrometers and multiple-disease diagnostic chips. The fourth presentation describes the use of optically interrogated microcantilevers that deflect when specific biomolecular binding occurs on one surface of a microcantilever beam. This approach may lead to a common platform for high-throughput label-free analysis of protein-protein binding, DNA hybridization, and DNA-protein interactions, as well as drug discovery. |
| Organizer: Michael Descour, PhD, The University of Arizona |
| 7:30-8:00 pm | Ming C. Wu, University of California, Los Angeles
"Cellular Resolution Endoscopic MEMS Imaging Devices" |
| 8:00-8:30 pm | David L. Dickensheets, Montana State University
"Progress toward a sub-2 mm diameter fluorescence confocal laser scanning microscope" |
| 8:30-9:00 pm | Axel Scherer, California Institute of Technology
"Integration of optoelectronics with microfluidics" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Combined Imaging Methodologies |
| Each imaging modality has a unique set of abilities and strengths. These abilities may include anatomical imaging, functional imaging, and the capability to image the entire body or to provide sub-cellular resolution. Also, every energy source interacts with tissue differently. Thus it may be that a particular medical or scientific problem cannot be fully explored using just one imaging methodology. For example, performing ultrasound and near infrared imaging yields two images with similar resolutions and fields of view but with different information about the tissue anatomy and functional state. In another case, magnetic resonance imaging can be used to provide a context for confocal microscopy's narrow and detailed look at tissue. In all cases, co-registration of the images is a crucial and frequently problematic process. In this session four speakers will talk about the benefits of combining imaging methodologies and solutions to the registration problem. |
| Organizer: Jennifer Kehlet Barton, Ph.D. , The University of Arizona |
| 9:00-9:45 am | Arjun G. Yodh, University of Pennsylvania
"Diffuse optical imaging with and without other technologies" |
| 9:45-10:30 am | Quing Zhu, University of Connecticut
"Ultrasound Assisted Optical Imaging for Breast Cancer Detection and Diagnosis" |
| 10:30-11:00 | Coffee Break |
| 11:00-11:45 am | Andres Kriete, TissueInformatics Inc.
"Imaging on hierarchical scales and tissue information systems" |
| 11:45-12:30 pm | Charles P. Lin, Wellman Laboratories of Photomedicine
"Combined in vivo confocal and two photon fluorescence microscopy in real time" |
| 12:30 pm | Lunch |
| 1:30-4:30 pm | Free of all formal activity |
| 4:30-6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:00-9:30 pm | Fluorescence Methods for Biomedical Diagnostics |
| This session will highlight recent developments using methods of fluorescence spectroscopy and imaging to obtain diagnostic information from biological systems. With an emphasis on applications that are pioneering in the field, talks will examine single cell fluorescence diagnostics using fiberoptic nanoprobes, fluorescent biosensors as an alternative to conventional clinical chemistry diagnostics, clinical diagnostics via fluorescence imaging, and fluorescence based photon migration for tomographic imaging. |
| Organizer: Mary-Ann Mycek, PhD, Dartmouth College |
| 7:30-8:00 pm | Eva Sevick-Muraca, PhD, Texas A&M University
"Fluorescence-enhanced biomedical optical imaging" |
| 8:00-8:30 pm | Michele Follen, MD, PhD, The UT MD Anderson Cancer Center
"Fluorescence and Reflectance Spectroscopy for Cervical Cancer Detection" |
| 8:30-9:00 pm | Dr. Tuan Vo-Dinh, Oak Ridge National Laboratory
"Optical Nanosensors: Monitoring Health at the Single Cell Level." |
| 9:00-9:30 pm | Zygmunt Gryczynski, University of Maryland
"Novel Fluorescence Sensing and Fluorescent Biosensors" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Advances in Optical Microscopy |
| This session will concentrate on the most important recent advances in optical microscopy. The speakers, all of whom are internationally respected, have been carefully chosen since they are responsible for some of the most exciting developments in modern microscopy and imaging. Two speakers have been invited from major laboratories in Europe and three from the United States. They work in complementary fields and since, in large part, their work is based on instrument and technique development, a Gordon Conference is the ideal venue to describe their work and to interact with future users in the biomedical and life sciences. This interaction is likely to lead to further instrument development informed by discussions with and input from bioscientists. |
| Organizer: Tony Wilson, University of Oxford |
| 9:00-9:35 am | Rudolf Oldenbourg, Woods Hole Oceanographic Institute
"A new generation of polarized light microscopes reveal dynamic cell architecture in two and three dimensions" |
| 9:35-10:10 am | Tony Wilson, University of Oxford
"New methods for extended depth of focus microscopy" |
| 10:10-10:45 | Coffee Break |
| 10:45-11:20 am | Peter So, MIT
"3-D Tissue Imaging and Informatics" |
| 11:20-11:55 am | Mats Gustafsson, University of California, San Francisco
"Fluorescence microscopy beyond the diffraction limit" |
| 11:55-12:30 pm | Claude Boccara, ULaboratoire d Optique ESPCI
"Optical Coherence Microscopy and High Spatial Resolution in 3-D" |
| 12:30 pm | Lunch |
| 1:30-4:30 pm | Free of all formal activity |
| 4:30-6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30-9:30 pm | Intra-vital Imaging and Microscopy |
| The "Intravital imaging and microscopy" session will focus on novel developments in optical imaging modalities to visualize living tissue morphology and function in real-time with very high resolution and contrast. Multiphoton-, confocal- and quadrature tomographic- microscopy are capable of imaging nuclear and cellular morphology, tissue architecture, and microvasculature and blood flow in humans and animals in vivo, and have been impressively applied for basic and clinical research. Four leading researchers will present technical innovations in these modalities with a strong emphasis on clinical applications such as mechanisms of tumor angiogenesis and drug delivery, detection of embryo viability, and diagnosis of human skin and other epithelial cancers. In addition to the oral presentations, leading groups from both academia and industry will present posters on technology development and diverse biomedical applications. |
| Organizer: Milind Rajadhyaksha, PhD, Lucid Inc. & Massachusetts General Hospital |
| 7:30-8:00 pm | `Rakesh Jain, Mass General Hospital
"Visualization of mechanisms of angiogenesis and drug delivery in solid tumors" |
| 8:00-8:30 pm | Charles A. DiMarzio, Northeastern University
"Quadrature tomographic microscope for detecting embryo viability" |
| 8:30-9:00 pm | Allan C. Halpern, Memorial Sloan-Kettering Cancer Center
"Confocal microscopy for pigmented skin cancers: diagnostic and clinical utility from a clinician's perspective" |
| 9:00-9:30 pm | Salvador Gonzalez, Massachusetts General Hospital
"Confocal imaging of non-pigmented skin cancers in vivo: potential benchmarks for clinical screening and diagnosis" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Wavefront Sensing and Adaptive Optics in Vision Correction |
| Wavefront sensors detect the optical aberration of the eye in much more detail than the conventional phoroptors in optometrists' offices. Correction of ocular wavefront aberration with adaptive optics techniques has shown that supernormal levels of contrast sensitivity and visual acuity can be achieved. In the past 2 years, laser refractive surgery techniques have also been applied to the correction of ocular wavefront aberrations. Promising results have been obtained in improving the quality of vision of both abnormally aberrated eyes and normal eyes. However, routine achievement of supernormal vision still lies in the future. Both the basic sciences and clinical results are discussed in this session. |
| Organizer: David Huang MD, PhD, Cleveland Clinic Cole Eye Intitute i32 |
| 9:00-9:45 am | George Pettit, Alcon Laboratories
"Hartmann Shack aberrometry applied to laser vision correction" |
| 9:45-10:30 am | Michael Mrochen , Univ. of Zurich
"Customized laser treatments for refractive corrections" |
| 10:30-11:00 | Coffee Break |
| 11:00-11:45 am | Leander Zickler, Univ. of Heidelberg
"Optical Quality of the human eye: the quest for supervision" |
| 11:45-12:30 am | Sofia I. Panagopoulou, PhD, Vardinoyiannion Eye Institute of Crete
"Asclepion Wavefront Analyzer for the measurement of the accommodation process" |
| 12:30 pm | Lunch |
| 1:30-4:30 pm | Free of all formal activity |
| 4:30-6:00 pm | Industrial Forum |
| 6:00 pm | Dinner |
| 7:30-9:30 pm | Recent advances in Photodynamic Therapy |
| The basic principle of PhotoDynamic Therapy (PDT) involves administration (topical, intravenous or oral) of a photosensitizing agent, followed by activation of the agent by visible light at a specific wavelength. This absorption of light, in turn, induces a chain of events that lead to the destruction of the lesion. A degree of selectivity in tissue destruction can be attained when the photosensitizer localizes specifically in the tissues to be destroyed. PDT started in oncology with very promising results and had a long and tedious way to optimized therapeutic strategies. Nevertheless, PDT has been approved by regulatory agencies throughout the world. Today, the step from oncology to non-oncology diseases is done; the latest major achievement being the treatment of a pathology of the retina, the age-related macular degeneration. More works are nevertheless needed to understand the basic mechanisms of PDT, to develop optimal photosensitizes and, consequently, to fully develop the large potential of this therapeutics. |
| Organizer: Georges Wagnieres, EPFL |
| 7:30-8:10 pm | Dr. Richard Mansfield, Royal United Hospital
"The treatment of intimal hyperplasia by PDT" |
| 8:10-8:50 pm | Prof. Brian Wilson, Ontario Cancer Institute
"Smart dosimetry in PDT" |
| 8:50-9:30 pm | Dr. Kristian Berg, Institute of Cancer Research, The Norwegian Radiumhospital
"Photochemical Internalization" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
