| SUNDAY |
| 2:00pm - 9:00pm | Arrival and check-in |
| 6:00pm | Dinner |
| 7:30pm - 7:40pm | Welcome from the Chair & Vice-Chair |
| RHODOPSIN STRUCTURE, FUNCTION AND ACTIVATION |
| 7:40pm - 7:55pm | Discussion Leader: Wayne Hubbell, University of California, Los Angeles |
| 7:55pm - 8:25pm | Jade Li, MRC Laboratory of Molecular Biology
Structure of native rhodopsin in a P3(1) crystal. |
| 8:25pm - 8:55pm | Wayne Hubbell, University of California, Los Angeles
Activation of rhodopsin |
| 8:55pm - 9:25pm | Daniel Oprian, Brandeis University
Protein/ligand interaction in rhodopsin |
| 9:25pm - 9:55pm | Oleg Kisselev, Saint Louis University
Light-induced conformational changes at rhodopsin-transducin interface explored by transfer NOE spectroscopy |
| MONDAY |
| 7:30am - 8:30am | Breakfast |
| LATE BREAKING STRUCTURE |
| 8:45am - 9:15am | Kaspar Locher, California Institute of Technology
Structure of an ABC transporter facilitating B12 uptake |
| STRUCTURE AND CONFORMATIONAL CHANGES OF SEVEN-HELIX RECEPTORS |
| 9:15am - 9:30am | Discussion leader: Ed Hulme, National Institute for Medical Research |
| 9:30am - 10:00am | Klaus Hofmann, Institut Fuer Medizinische Physik Und Biophysi
Signalling states of rhodopsin |
| 10:00am | Coffee Break |
| 10:30am - 11:00am | Jurgen Wess, NIH-NIDDK
Activation of G protein-coupled receptors studied with the M3 muscarinic
receptor as a model system |
| 11:00 - 11:30am | Brian Kobilka, Stanford University
Activation of the b-adrenergic receptor |
| 11:30am - Noon | Hisato Jingami, Biomolecular Engineering Research Institute
Ligand recognition and initial activation in mGluR |
| Noon - 12:30pm | Janos Lanyi, University of California
X-ray diffraction structures of the photointermediates of bacteriorhodopsin |
| 12:30pm | Lunch |
| KEYNOTE SPEAKER |
| 4:45pm - 5:30pm | Roderick MacKinnon, HHM/Rockefeller University
Structure and function of ion channels |
| MOLECULAR DETERMINANTS OF ION CHANNEL GATING |
| 5:30pm - 5:45pm | Discussion leader: Gerd Kochendoerfer, Gryphon Sciences, San Francisco |
| 5:45pm - 6:15pm | Joseph Mindell, Brandeis University
Three-dimensional structure of a ClC chloride channel |
| 6:15pm - 6:45pm | Kenton Swartz, NINDS-NIH
Domain interactions underlying activation gating in the Shaker K+ channel |
| 6:45pm - 7:15pm | Terrance Egan, St Louis University Medical School
P2X receptors |
| 7:15pm - 7:45pm | Eduardo Perozo, University of Virginia
The mechanics of mechanosensitive channel gating |
| 8:00pm | Dinner |
| TUESDAY |
| 7:30am - 8:30am | Breakfast |
| STRUCTURE AND CONFORMATIONAL CHANGES OF TRANSPORTERS |
| 8:45am - 9:00am | Discussion leader: Ulrik Gether, Copenhagen University Hospital |
| 9:00am - 9:30am | Chris Tate, MRC Laboratory of Molecular Biology
Structure of EmrE, a bacterial multidrug transporter, by electron microscopy |
| 9:30am - 10:00am | Shimon Schuldiner, Hebrew University of Jerusalem
Coupling of H+ and substrate fluxes in EmrE, an ion-coupled multidrug
transporter, is based on "time-sharing" of a common binding site |
| 10:00am | Coffee Break |
| 10:30am - 11:00am | Peter Maloney, Johns Hopkins Medical School
Biology and biophysics of OxlT, a membrane carrier |
| 11:00am - 11:30am | Jonathan Javitch, Columbia University
Oligomerization of the human dopamine transporter: what, where, and why? |
| 12:30pm | Lunch |
| NUCLEOTIDE-GATED CHANNELS |
| 5:30pm - 5:45pm | Discussion leader: Benjamin Kaupp, FZD-IBI |
| 5:45pm - 6:15pm | Matthew Higgins, University of Cambridge
Shedding light on the vision channel |
| 6:15pm - 6:45pm | Reinhard Seifert, Inst Biol Informationsverarbeitung
Pore Gating and the Beta Subunit |
| 6:45pm - 7:15pm | Steven Siegelbaum, Columbia University
Dynamic allosteric regulation of channel gating by cyclic nucleotide |
| 7:15pm - 7:45pm | Richard Kramer, University of California
Modulation of cyclic nucleotide-gated channels and regulation of phototransduction |
| 8:00pm | Dinner |
| WEDNESDAY |
| 7:30am - 8:30am | Breakfast |
| NICOTINIC RECEPTOR AND RELATED CHANNELS |
| 8:45am - 9:00am | Discussion leader: Titia Sixma, Netherlands Cancer Institute |
| 9:00am - 9:30am | Atsuo Miyazawa, Riken, Harima Institute
Structure and activation mechanism of acetylcholine receptor |
| 9:30am - 10:00am | Dennis Dougherty, California Institute of Technology
Ligand recognition at the nicotinic acetylcholine and 5-HT3 serotonin receptors |
| 10:00am | Coffee Break |
| 10:30am - 11:00am | John Leite, Caltech
Mass spectrometry studies of nicotinic receptor conformational transitions |
| 11:00am - 11:30am | Thomas Sudhof, University of Texas, South Western Medical Centre
Regulation of neurotransmitter release by cell-surface signalling receptors |
| MEMBRANE PROTEIN EXPRESSION |
| 11:30am - 11:45am | Discussion leader: Chris Tate, MRC Laboratory of Molecular Biology |
| 11:45am - 12:05pm | Gerd Kochendoerfer, Gryphon Sciences, San Francisco
Total chemical synthesis of native and custom-modified ion channel proteins |
| 12:05pm - 12:25pm | Kenneth Lundstrom
In vivo membrane protein expression using Semliki Forest virus. |
| 12:30pm | Lunch |
| MEMBRANE PROTEIN ASSEMBLY AND 3D STRUCTURE |
| 5:30pm - 5:45pm | Discussion leader: Jean-Luc Popot, CNRS UPR 9052 |
| 5:45pm - 6:15pm | Nealialyssa Armstrong, Columbia University
Structure and function of ionotropic glutamate receptors |
| 6:15pm - 6:45pm | Hartmut Oschkinat, Forschungs Inst Fur Molekulare Pharmekolo
Solution and solid-state NMR approaches for membrane protein structure determination |
| 6:45pm - 7:15pm | Teruhisa Hirai, NCI/NIH
Three dimensional structure of a bacterial oxalate transporter |
| 7:15pm - 7:45pm | Cecile Breyton, CNRS
Structure and oligomeric properties of a bacterial core protein translocase |
| 8:00pm | Dinner |
| THURSDAY |
| 7:30am - 8:30am | Breakfast |
| MOLECULAR MODELLING OF CHANNELS, RECEPTORS AND TRANSPORTERS |
| 8:45am - 9:00am | Discussion leader: Barry Honig, Columbia University |
| 9:00am - 9:30am | Donald Engelman, Yale University
New perspectives on the chemistry of membrane protein stability |
| 9:30am - 10:00am | Grace Rosenquist, University of California, Davis
Posttranslational Modification of 7tm receptors |
| 10:00am | Coffee Break |
| 10:30am - 11:00am | Nir Ben-Tal, Tel Aviv University
Energetic principles of membrane protein structure and function |
| 11:00am - 11:30am | Frank Blaney, GSK
The use of seven-helix models in drug design |
| 11:30am - Noon | Christopher Reynolds, Department of Biological Sciences, Essex
Dimerisation of G-protein coupled receptors |
| 12:30pm | Lunch |
| ORGANISATION OF SEVEN-HELIX RECEPTORS, CHANNELS AND TRANSPORTERS INTO LARGER COMPLEXES |
| 5:30pm - 5:45pm | Discussion leader: Thue Schwartz, University of Copenhagen |
| 5:45pm - 6:15pm | Robert Molday, University of British Columbia
cGMP-gated channel-protein interactions in rod photoreceptors |
| 6:15pm - 6:45pm | Charles Zuker, Howard Hughes Med Inst/UCSD
Sensory signalling |
| 6:45pm - 7:15pm | Mark Zastrow, Psychiatry & Pharmacology, UCSF
Protein interactions controlling membrane trafficking of GPCRs in the endocytic pathway |
| 8:00pm | Dinner |
