SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE LECTURE |
| Discussion Leader: Doug Rees (Caltech) |
7:30 pm - 8:30 pm | Ron Kaback (UCLA)
"Structure and Mechanism of Lactose Permease" |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VOLTAGE SENSING IN ION CHANNELS |
9:00 am - 9:40 am | Doug Rees (Caltech)
"Crystal Structures of Prokaryotic Mechanosensitive Channels" |
9:40 am - 10:00 am | Eduardo Perozo (Viginia)
"Structural Dynamics of the KvAP voltage-dependent potassium channel in a lipid bilayer" |
10:00 am | Conference Photo / Coffee Break |
10:30 am - 11:10 am | Pancho Bezanilla (UCLA)
"Structure Function in Voltage Dependent Ionic Channels" |
11:10 am - 11:50 am | Diane Papazian (UCLA)
"Voltage-dependent gating in potassium channels" |
11:50 am - 12:30 pm | Bob Guy (NIH)
"Helical Screw models of voltage gating developed from the KvAP crystal structures" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:20 pm | ACTIVE TRANSPORTERS |
7:30 pm - 7:55 pm | Geoff Chang (Scripps)
"Structure of Multidrug Resistance Transporters" |
7:55 pm - 8:20 pm | Da-Neng Wang (NYU)
"Crystal structure and mechanism of the glycerol-3-phosphate transporter of E. coli." |
8:20 pm - 9:30 pm | RHODOPSIN AND RELATED STRUCTURES |
8:20 am - 8:55 pm | Gebhard Schertler (MRC)
"Light induced states of rhodopsin in 2D and 3D crystals" |
8:55 am - 9:30 pm | Arlene Albert (U. Conn.)
"Activation of the GPCR Rhodopsin" |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SELECTIVITY IN TRANSPORTERS |
9:00 am - 9:40 am | Bob Stroud (UCSF)
"Selectivity and gating among the aquaporin family" |
9:40 am - 10:00 am | Chris Tate (MRC, Cambridge)
"Architecture and oligomeric state of the bacterial multidrug transporter EmrE" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Helmut Grubmüller (Max Plank; Göttingen)
"Molecular mechanisms of aquaporins and F1 ATP synthase studied by protein dynamics simulations" |
11:10 am - 11:50 am | Susan Buchanan (NIH)
"Structural evidence for iron-free citrate and ferric citrate binding to the TonB-dependent outer membrane transporter FecA" |
11:50 am - 12:30 pm | Mike Wiener (Virginia)
"The outer membrane cobalamin transporter BtuB: structural analysis and mechanistic implications" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HCN and OTHER K+ CHANNELS |
| Discussion Leader: Benjamin Kaupp (Jülich) |
7:30 pm - 8:10 pm | Klaus Benndorf (Jena)
"Gating of CNGA1 and CNGA2 channels studied by flash photolysis" |
8:10 pm - 8:50 pm | Gary Yellen (Harvard)
"Inactivation and coupling in HCN pacemaker channels" |
8:50 pm - 9:30 pm | Adrien Gross (Northwestern)
"Potassium channel gating observed with site-directed mass tagging" |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | RECOGNITION in LIGAND-GATED ION CHANNELS |
9:00 am - 9:40 am | Titia Sixma (Netherlands Cancer Institute)
"Insights in nicotinic receptor ligand-binding through AChBP crystal structures" |
9:40 am - 10:00 am | Gabriela Popescu (SUNY, Buffalo)
"Kinetics of binding to NMDA receptors: learning from single channels" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | James Trudell (Stanford)
"Molecular modeling of ligand gated ion channels: comparison with experimental results" |
11:10 am - 11:50 am | Cynthia Czajkowski (Wisconsin)
"GABA-A Receptors: Structural Determinants of Ligand Recognition and Allosteric Cross-talk" |
11:50 am - 12:30 pm | Jonathan Cohen (Harvard)
"Photolabeling of Nicotinic and GABA-A Receptors" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HERG/CHANNEL BLOCKERS |
7:30 pm - 8:10 pm | Mike Sanguinetti (Utah)
"Structural basis of HERG channel block: a common cause of drug-induced long QT syndrome" |
8:10 pm - 8:50 pm | Bill Catterall (Washington)
"Mapping the Inner Pore and Drug Binding Sites of Voltage-gated Sodium Channels" |
8:50 pm - 9:30 pm | Greg Kaczorowski (Merck)
"Interactions of small molecules with potassium channels" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | NEW PROBES OF RECEPTOR BINDING and GATING |
9:00 am - 9:40 am | Henry Lester (Caltech)
"Fluorescence studies on nicotinic receptors" |
9:40 am - 10:00 am | Adam Weinglass (UCLA)
"Exploiting mass spectrometry to probe substrate binding sites in membrane transport proteins?" |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Horst Vogel (Lausanne)
"Ligand-receptor interactions by single molecule technologies" |
11:10 am - 11:50 am | Ann McDermott (Columbia)
"Structural and Dynamic Studies of Membrane Associated Proteins: High Resolution Solid State NMR" |
11:50 am - 12:30 pm | Andreas Engel (Basel)
"Assessing membrane protein structure and dynamics with electron and atomic force microscopy" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | GPCR |
7:30 pm - 8:10 pm | Thue Schwartz (Copenhagen)
"Agonist versus antagonist recognition and gating in 7TM receptors" |
8:10 pm - 8:50 pm | Jennifer Whistler (UCSF)
"RAVE trafficking and addiction: a GPCR's journey" |
8:50 pm - 9:30 pm | Michel Bouvier (Montreal)
"Assembly of G Protein-Coupled Receptor Signaling Complexes" |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |