SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:00 pm | KEYNOTE LECTURE |
| Discussion Leader: Susan Buchanan (National Institutes of Health, Bethesda) |
7:40 pm - 8:40 pm | Kaspar Locher (Eidgenössische Technische Hochschule, Zürich)
"Structures of ABC transporters facilitating nutrient uptake or drug extrusion" |
8:40 pm - 9:00 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LIGAND-GATED ION CHANNELS |
| Discussion Leader: Rick Aldrich (University of Texas at Austin) |
9:00 am - 9:20 am | Mark Mayer (National Institutes of Health, Bethesda)
"Activation and allostery in glutamate receptor ion channels: Insights from crystallographic and functional studies" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Myles Akabas (Albert Einstein College of Medicine of Yeshiva University, Bronx) "Modular design and constraints for homology models of the GABA and 5-HT3 neurotransmitter-gated ion channels" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Claudio Grosman (University of Illinois at Urbana-Champaign) "Individual proton-transfer events as a probe of the structure and electrostatics of the nicotinic-receptor channel pore" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Poster Contribution: Joel Gever (Roche Pharmaceuticals, Palo Alto) "P2X Receptors as Targets for Urology and Pain" |
11:15 am - 11:30 am | Group Photo |
11:30 am - 11:50 am | Eduardo Perozo (University of Chicago)
"Structural mechanisms of K+ channel activation and inactivation gating" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Jay Jasti (Oregon Health & Science University, Portland)
"Crystal structure of an acid-sensing ion channel" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | MEMBRANE PROTEINS ASSESSED BY NMR |
| Discussion Leader: Jean-Luc Popot (Centre National de la Recherche Scientifique / Université Paris-7) |
7:30 pm - 7:50 pm | Volker Dötsch (University of Frankfurt)
"Combination of cell-free expression and NMR spectroscopy for the structure determination of membrane proteins" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Lynmarie Thompson (University of Massachusetts, Amherst)
"Assembly and structural changes of bacterial chemotaxis receptor signaling complexes" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Poster Contribution: Crina Nimigean (University of California at Davis) "The EM Structure of the Prokaryotic Cyclic Nucleotide-modulated Potassium Channel Mlok1" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Steve Smith (Stony Brook University)
"Solid-state NMR studies on the activated state of rhodopsin" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | SMALL AND LARGE MOLECULE TRANSPORT |
| Discussion Leader: Carola Hunte (Max Planck Institute of Biophysics, Frankfurt) |
9:00 am - 9:20 am | Jim Naismith (University of St. Andrews)
"Wza, a new class of membrane protein" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Emad Tajkhorshid (University of Illinois at Urbana-Champaign)
"Dynamics of substrate binding, gating, and energy coupling in membrane transporters" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Vinzenz Unger (Yale University, New Haven)
"Structure of the human copper transporter CTR1" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Amanda Stouffer (Eidgenössische Technische Hochschule, Zürich)
"Structural basis for the function and pharmaceutical inhibition of an influenza virus proton channel" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Mike Merrick (John Innes Centre, Norich)
"The AmtB-GlnK complex: regulating the bacterial ammonia channel" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Mike Maguire (Case Western Reserve University, Cleveland)
"Structure-Function of CorA, a Mg2+ channel involved in Salmonella virulence" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session I |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | FOLDING AND LIPID-PROTEIN INTERACTIONS |
| Discussion Leader: Kenton Swartz (National Institutes of Health, Bethesda) |
7:30 pm - 7:50 pm | Gunnar von Heijne (Stockholm University)
"Insertion of transmembrane helices into the ER: experiment-based computational models" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Carol Deutsch (University of Pennsylvania, Philadelphia)
"Kv channels and the ribosome: tunnel vision" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Poster Contribution: Laurent Maveyraud (Institut de Pharmacologie et de Biologie Structurale du CNRS et de l'Université Paul Sabatier, Toulouse) "Structural studies on staphylococcal pore forming toxins: towards the understanding of pore-formation" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Zhe Lu (University of Pennsylvania, Philadelphia)
"Ion channel function and membrane phospholipids" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | VOLTAGE-GATED ION CHANNELS |
| Discussion Leader: Mark Mayer (National Institutes of Health, Bethesda) |
9:00 am - 9:20 am | Rick Aldrich (University of Texas at Austin)
"Gating of potassium channels" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ofer Yifrach (Ben-gurion University of the Negev, Beer Sheva)
"Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Poster Contribution: Brittany Zadek (University of Oxford) "Different Gating Conformations of KirBac3.1 Determined Using Cryo-EM and AFM" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Mark Sansom (University of Oxford) "Simulation Studies of Voltage Sensors: Interactions with Lipids and Water" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Kenton Swartz (National Institutes of Health, Bethesda)
"Toxins interacting with paddle motifs in voltage-sensing proteins" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | David Yue (Johns Hopkins University, Baltimore)
"Mechanism of Ca2+ decoding by the CaM/Ca channel complex" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | NEW METHODS FOR STRUCTURAL ANALYSIS OF MEMBRANE PROTEINS |
| Discussion Leader: Gebhard Schertler (Medical Research Council Laboratory of Molecular Biology, Cambridge) |
7:30 pm - 7:50 pm | Jean-Luc Popot (Centre National de la Recherche Scientifique / Université Paris-7)
"Amphipol-mediated renaturation and immobilization of membrane proteins" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Poster Contribution: Karen Martinez (University of Copenhagen) "Monitoring the diffusion of single heterotrimeric G proteins in supported cell-membrane sheets reveals their partitioning into microdomains: a single-molecule study" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Filippo Mancia (Columbia University, New York) "Asymmetry and Ligand Sensitivity in Dimeric Associations of the Serotonin 5HT2c Receptor" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Chris Tate (Medical Research Council Laboratory of Molecular Biology, Cambridge)
"A generic methodology to stabilise GPCRs in detergent solution for structural studies" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | LIGAND RECOGNITION IN G-PROTEIN COUPLED RECEPTORS |
| Discussion Leader: Reinhard Grisshammer (National Institutes of Health, Bethesda) |
9:00 am - 9:20 am | Roger Sunahara (University of Michigan, Ann Arbor)
"Does oligomerization of G protein-coupled receptors regulate coupling to G proteins?" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Hisato Jingami (Kyoto University)
"Structural studies of mGluR and related molecules" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | Midori Murakami (Nagoya University)
"Crystal structure of squid rhodopsin" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Poster Contribution: Feng Yan (University of North Carolina at Chapel Hill) "The Design and Use of Covalently Bound Agonists To Probe GPCR Structures: Direct Identification of Anchoring Residues by MS/MS in the Kappa-Opioid Receptor" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Gebhard Schertler (Medical Research Council Laboratory of Molecular Biology, Cambridge)
"Structure of the Beta 1 Adrenergic Receptor: Progress in Obtaining Recombinant G Protein Coupled Receptor Structures" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Brian Kobilka (Stanford University)
"Structure and dynamics of the human beta 2 adrenergic receptor" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session II |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | NUCLEOTIDE-COUPLED TRANSPORTERS |
| Discussion Leader: Vinzenz Unger (Yale University, New Haven) |
7:30 pm - 7:50 pm | Heather Pinkett (California Institute of Technology, Pasadena)
"Structural Studies of the HIF Transporter" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Peter Tieleman (University of Calgary)
"Computer simulations of ABC transporters" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Poster Contribution: Raz Zarivach (University of British Columbia, Vancouver) "Structural analysis of the essential inner membrane type III secretion proteins EscN and EscU" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Poul Nissen (Aarhus University)
"The structure, function and regulation of P-type ATPase pumps" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |