| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:00 pm | KEYNOTE LECTURE |
| Discussion Leader: Carola Hunte (University of Freiburg) |
| 7:40 pm - 8:40 pm | Eric Gouaux (Oregon Health & Science University)
"Dissection of conformational changes in sodium coupled transporters" |
| 8:40 pm - 9:00 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | STRUCTURES AND MECHANISM OF SECONDARY TRANSPORTERS |
| 9:00 am - 9:05 am | Discussion Leader: Etana Padan (The Hebrew University) |
| 9:05 am - 9:25 am | Peter Henderson (University of Leeds)
"The Mhp1 membrane transport protein - ligand recognition and molecular mechanism" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:50 am | Poster Presentation: Michael Merrick (John Innes Centre)
"Control of flux through the ammonia channel AmtB by the signal transduction protein GlnK and intracellular levels of ATP, ADP and 2-oxoglutarate" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break / Group Photo |
| 10:30 am - 10:50 am | Nieng Yan (Tsinghua University)
"Structure of a MFS sugar transporter" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Olga Boudker (Cornell University)
"Molecular mechanism of glutamate transporters" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Sabrina Schulze (Max Planck Institute of Biophysics)
"Structural basis of allosteric substrate translocation in the sodium-independent carnitine/butyrobetaine transporter CaiT" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Christopher Miller (Brandeis University)
"Monomeric CLC transporters" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | NUCLEOTIDE-COUPLED TRANSPORTERS |
| Discussion Leader: Heinrich Jung (LMU Munich) |
| 5:30 pm - 5:50 pm | Bert Poolman (University of Groningen)
"A structural classification of substrate-binding proteins and the mechanism of peptide selection by the ABC transport receptor OppA" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Amy Davidson (Purdue University)
"Structure and mechanism of action of the ABC maltose transporter" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Poster Presentation: Dirk Slotboom (University of Groningen)
"A large new class of ABC transporters without soluble substrate binding proteins" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Hassane S. Mchaourab (Vanderbilt University)
"Dynamics of Active Transporters: Perspectives from Spin Labeling EPR" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CATION AND GAP-JUNCTION CHANNELS |
| Discussion Leader: Kenton Swartz (NIH/NINDS) |
| 9:00 am - 9:20 am | Tomitake Tsukihara (Osaka University)
"Structure and function of Connexin26 gapjunction channel" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Vytautas Verselis (Albert Einstein College of Medicine)
"Gating and regulation of connexin channels and hemichannels " |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | David Clapham (HHMI, Children´s Hospital, Harvard Medical School)
"Novel ion channels" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Baron Chanda (University of Wisconsin)
"Molecular mechanisms of electromechanical coupling in voltage-dependent sodium channels" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Poster Presentation: Klaus Benndorf (University Hospital Jena)
"Interdependence of voltage- and ligand-induced activation in homotetrameric HCN2 channels" |
| 12:00 pm - 12:30 pm | Eitan Reuveny (Weizmann Institute of Science)
"Control of GIRK channel gating by nonenzymatic activity of the G protein coupled receptor kinase" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | MEMBRANE-PROTEIN LIPID INTERACTIONS |
| Discussion Leader: Crina Nimigean (Cornell University) |
| 5:30 pm - 5:50 pm | Anthony Lee (University of Southampton)
"How lipids affect ion channel function" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Poster Presentation: Younes Mokrab (University of Oxford)
"Homologous voltage-sensing domains detailed interactions with the lipid bilayer revealed by self-assembly molecular dynamics simulations" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Richard Hite (Harvard Medical School)
"Annular Lipid-Protein Interactions in Aquaporin-0 Two-Dimensional Crystals" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Mark Samson (University of Oxford)
"Multiscale Simulations of Membrane Signalling Proteins: Application to Integrins" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | PASSAGES THROUGH THE OUTER MEMBRANE |
| Discussion Leader: Susan Buchanan (NIDDK,NIH) |
| 9:00 am - 9:20 am | Bert van den Berg (UMASS Medical School)
"Bacterial cleanup: uptake of hydrophobic molecules across the outer membrane" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Colin Kleanthous (University of York)
"The role of intrinsic disorder in outer membrane translocation by antibacterial colicins" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:35 am - 10:50 am | Poster Presentation: Vidya Chandran (University College London)
"Structure of a bacterial type IV secretion core complex" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Susan Buchanan (NIDDK,NIH)
"Import of bacteriocins across the bacterial outer membrane: engineering a phage lysin to kill Yersina pestis" |
| 11:30 am - 12:00 pm | Jeff Abramson (UCLA)
"The crystal structure of mouse VDAC1 resides in a native and open conformation" |
| 12:00 pm - 12:20 pm | Gerhard Wagner (University of Zurich)
"Structure and interactions of human Voltage Dependent Anion Channel in micelles and nanodiscs" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | LIGAND-GATED ION CHANNELS |
| Discussion Leader: Ernst Bamberg (Max Planck Institute of Biophysics) |
| 5:30 pm - 5:50 pm | Toshi Kawate (NIH/NINDS)
"Architecture of ATP-gated ion channels: crystal structure of P2X4 receptor" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Steven M. Sine (Mayo Clinic)
"Structural and mechanistic underpinnings of nicotinic receptor activation" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Joao Morais-Cabral (IBMC Porto)
"Structural studies of a cyclic nucleotide regulated potassium channel" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Raimund Dutzler (University of Zurich)
"A structural perspective on pentameric ligand-gated ion channel function" |
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 8:00 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 8:00 pm | Dinner |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NEW METHODS PROBING MEMBRANE PROTEIN STRUCTURES, CONFORMATIONS AND LIGAND BINDING |
| Discussion Leader: Bert Poolman (University of Groningen) |
| 9:00 am - 9:20 am | Daniel Müller (ETH Zurich)
"New technologies to image and functionally probe single membrane proteins at subnanometer resolution in vitro and in vivo" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Ernst Bamberg (Max Planck Institute of Biophysics)
"Optogenetics: Channelrhodopsin 2 molecular mechanism and applications in neurobiology" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am | Coffee Break |
| 10:30 am - 10:50 am | Dimitrios Stamou (University of Copenhagen)
"A vesicle-based high throughput assay to monitor the activity of single ion channels and transporters" |
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Poster Presentation: David Drew (Imperial College)
"Validation of a GFP-based optimization scheme for the overexpression and purification of membrane proteins for structural studies" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Hartmut Oschkinat (FU Berlin)
"ABC transporters by solid-state NMR: Insights into the transport cycle of ArtMP-J" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:30 pm | Daniel Nietlispach (University of Cambridge)
"Structure determination of the seven-helical membrane protein sensory rhodopsin II" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | G-PROTEIN COUPLED RECEPTORS AND INTERACTION WITH G-PROTEINS AND LIGANDS |
| Discussion Leader: Gebhard Schertler (MRC-LMB) |
| 5:30 pm - 5:50 pm | Joerg Standfuss (Paul Scherrer Institute)
"Agonist binding and GPCR activation as visualized by the x-ray structure of constitutively active rhodopsin" |
| 5:50 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:20 pm | Klaus-Peter Hofmann (IMPB, Charite Berlin)
"Signal transfer from receptor to G protein: Insights from spectroscopic and structural studies on rhodopsin" |
| 6:20 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:50 pm | Poster Presentation: Stefan Haberstock (Goethe University of Frankfurt)
"Optimization strategies for GPCR expression in E.coli cell-free expression systems" |
| 6:50 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:20 pm | Brian Kobilka (Stanford University)
"The dynamic process of GPCR activation: insights from the human beta 2 adrenoceptor" |
| 7:20 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
