SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
7:35 pm - 9:30 pm | GPCR Activation |
| Discussion Leader: Reinhard Grisshammer (NIH) |
7:35 pm - 8:00 pm | Jörg Standfuss (Paul Scherrer Institut, Villigen, Switzerland)
"Structures of Rhodopsin Mutants that Cause Night Blindness and Retina Degeneration"
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8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Ron Dror (D.E. Shaw Research and Stanford University)
"Structural Basis for Allosteric Modulation of GPCRs"
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8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Brian Kobilka (Stanford University)
"The Dynamic Process of GPCR Activation: Insights from the Human β2 Adrenoceptor"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Cation Channel Gating |
| Discussion Leader: Crina Nimigean (Weill Cornell Medical College) |
9:00 am - 9:25 am | Rachelle Gaudet (Harvard University)
"Structural Insights into TRPV Channel Function in Health and Disease"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Zhaozhu Qiu (The Scripps Research Institute)
"The Volume-Regulated Anion Channel VRAC"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Kenton Swartz (NIH)
"Exploring Ion Channel Structure and Gating Mechanisms with Tarantula Toxins"
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10:15 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:10 am | Rick Aldrich (The University of Texas at Austin)
"SK Channel Gating and Calmodulin"
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11:10 am - 11:20 am | Discussion |
11:20 am - 11:30 am | Alexandru Aricescu (University of Oxford, UK)
"Crystal Structure of a Human GABAA Receptor: Insights into Function and Disease"
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11:30 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Qiu-Xing Jiang (UT Southwestern Medical Center)
"Lipid-Dependent Gating Effects on a Voltage-Gated Potassium Channel"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Alexander M. Cruickshank Award Lecture: Eric Gouaux (Oregon Health & Science University)
"Mechanism of Gating in Ionotropic Glutamate Receptors"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structure of GPCRs |
| Discussion Leader: Edmund Kunji (Medical Research Council, Cambridge, UK) |
7:30 pm - 7:55 pm | Martha Sommer (Institut für Medizinische Physik und Biophysik, Berlin, Germany)
"Arrestin-GPCR Interactions"
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7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Reinhard Grisshammer (NIH)
"The Biology of Neuropeptide Receptors"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Chris Tate (Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK)
"Structures of Agonist-Bound GPCRs: Understanding Ligand Efficacy and Receptor Activation"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Secondary Active Transporters |
| Discussion Leader: Olga Boudker (Weill Cornell Medical College) |
9:00 am - 9:25 am | Lucy Forrest (NIH)
"The Role of Sodium in Coupled Uptake by BetP"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Dorothy Kim (Weill Cornell Medical College)
"Proton-Dependent Conformational Dynamics in KcsA"
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9:45 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Poul Nissen (Aarhus University, Denmark)
"New Structures and Functional Insight of the Neurotransmitter-Sodium Symporters"
|
10:15 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:50 am - 11:15 am | Joe Mindell (NIH)
"Conformational Changes in Secondary Active Transporters"
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11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | David Drew (University of Stockholm, Sweden)
"A Two-Domain Elevator Mechanism for Sodium/Proton Antiport"
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11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Cristina Paulino (MPI Frankfurt, Germany)
"pH- and Sodium-Induced Changes in a Sodium/Proton Antiporter"
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11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Carola Hunte (University of Freiburg, Germany)
"Ion Translocation by Sodium/Proton Antiporters"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Bacterial Specialties |
| Discussion Leader: Hassane Mchaourab (Vanderbilt University Medical Center) |
7:30 pm - 7:55 pm | Susan Buchanan (NIH)
"Structural Insight into the Biogenesis of β-Barrel Membrane Proteins"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Katherine Henzler-Wildman (Washington University in St. Louis)
"Multidrug Recognition by EmrE"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Bert Poolman (University of Groningen, The Netherlands)
"ABC Transporters: Ligand Binding Mechanism and Substrate Delivery at the Single Molecule Level"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Spectroscopic and Microscopic Methods |
| Discussion Leader: Robert Tampé (Johann Wolfgang Goethe-University, Frankfurt, Germany) |
9:00 am - 9:25 am | Vadim Cherezov (The Scripps Research Institute)
"Serial Femtosecond Crystallography of G Protein-Coupled Receptors"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Maofu Liao (UCSF)
"Structure of the TRPV1 Ion Channel Determined by Electron Cryo-Microscopy"
|
9:45 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Enrica Bordignon (Freie Univerität, Berlin, Germany)
"EPR Snapshots of Spin-Labeled ABC Transporters During Nucleotide Cycle"
|
10:15 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:45 am - 11:10 am | Antoine van Oijen (University of Groningen, The Netherlands)
"Single-Molecule Fluorescence Studies of Membrane Transporters"
|
11:10 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Baron Chanda (University of Wisconsin)
"Deconstructing Allostery Using Fluorescent Ligand Binding Measurements" |
11:45 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Simon Scheuring (INSERM, Université de la Méditerannée, Marseille, France)
"Channel Structure and Interaction Studied by Atomic Force Microscopy"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Channels |
| Discussion Leader: Rick Aldrich (The University of Texas at Austin) |
7:30 pm - 7:55 pm | João Morais Cabral (IBMC, Porto, Portugal)
"Structure and Function of a Potassium Transporter"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Randy Stockbridge (Brandeis University)
"Dual Topology Architecture of Fluoride-Selective Ion Channels"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Raimund Dutzler (University of Zürich, Switzerland)
"The Structural Basis for Transition Metal Ion Selectivity in Transporters of the SLC11/NRAMP Family" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ABC Transporters |
| Discussion Leader: Rachelle Gaudet (Harvard University)
|
9:00 am - 9:25 am | Ina Urbatsch (Texas Tech University Health Sciences Center)
"Directed Evolution of P-Glycoprotein Cysteines Reveals Site-Specific, Non-Conservative Substitutions that Preserve Multidrug Resistance"
|
9:25 am - 9:35 am | Discussion |
9:35 am - 9:45 am | Olga Boudker (Weill Cornell Medical College)
"Hypothetical Mechanism of Potassium Coupling in Glutamate Transporters" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:15 am | Hassane Mchaourab (Vanderbilt University Medical Center)
"Mechanistic Diversity of ABC Exporters" |
10:15 am - 10:25 am | Discussion |
10:25 am | Coffee Break |
10:50 am - 11:15 am | Robert Tampé (Johann Wolfgang Goethe-University, Frankfurt, Germany)
"INs and OUTs of Antigen Processing: The ABC of Adaptive Immunity"
|
11:15 am - 11:25 am | Discussion |
11:25 am - 11:35 am | Eric Accili (University of British Columbia)
"Probing Cyclic Nucleotide Binding and Action on HCN Channels Using cAMP Analogs"
|
11:35 am - 11:40 am | Discussion |
11:40 am - 11:50 am | Jonas Lee (California Institute Technology)
"Structural and Functional Characterization of a Heavy Metal Detoxifying ABC Transporter"
|
11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Kaspar Locher (ETH, Zurich, Switzerland)
"Mechanism of Cobalamin Transport Across the ABC Transporter BtuCD-F"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mitochondrial Transport Functions |
| Discussion Leader: Bert Poolman (University of Groningen, The Netherlands) |
7:30 pm - 7:55 pm | Edmund Kunji (Medical Research Council, Cambridge, UK)
"Molecular Mechanism of Transport and Regulation of Mitochondrial Carriers"
|
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Océane Frelin (University of Florida)
"Identification of Mitochondrial Cofactor Transporters in Plants"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | John Walker (Medical Research Council, Cambridge, UK)
"Proton and Calcium Channels in ATP Synthase" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |