Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | G Protein Coupled Receptors |
| Discussion Leader: Gebhard Schertler (Paul Scherrer Institute / ETH Zürich, Switzerland) |
7:40 pm - 8:00 pm | Klaus-Peter Hofmann (Charite Institute for Medical Physics and Biophysics, Germany) "Versatility and Precision of GPCR Interactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Andreas Pluckthun (University of Zurich, Switzerland) "Evolving Stable Receptors: Principles, Structural Studies and Use in Drug Discovery" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Chris Tate (Medical Research Council, United Kingdom) "Crystal Structure of the Human Adenosine A2a Receptor Bound to an Engineered G Protein" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ehud Isacoff (University of California, Berkeley, USA) "An Optical View of mGluR Gating Mechanism" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Physiology of Transporters and Channels |
| Discussion Leader: Edmund Kunji (MRC - Mitochondrial Biology Unit, United Kingdom) |
9:00 am - 9:20 am | Geoffrey Abbott (University of California, Irvine, USA) "Potassium Channel-Solute Transporter Co-Regulation" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Stephan Pless (University of Copenhagen, Denmark) "Atomic Basis for Therapeutic Activation of Neuronal Potassium Channels" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Frances Ashcroft (University of Oxford, United Kingdom) "KATP Channels and Neonatal Diabetes: When Ligand Recognition Goes Wrong" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Nancy Carrasco (Yale School of Medicine, USA) "The Sodium/Iodide Symporter (NIS): An Unending Source of Surprises" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Andres Jara-Oseguera (National Institute of Neurological Disorders and Stroke, NIH, USA) "Extracellular Sodium Is Required for Temperature-Dependent Gating in TRPV1 Channels" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Isabelle Mus-Veteau (CNRS, France) "The Human Hedgehog Receptor Patched Is a Cholesterol and a Drug Efflux Pump" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Benjamin Kaupp (Center of Advanced European Studies and Research, Germany) "Chemotactic Signaling by Exotic Ion Channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Teresa Giraldez (La Laguna University, Spain) |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Calcium Release and Calcium-Gated Channels |
| Discussion Leader: Teresa Giraldez (La Laguna University, Spain) |
6:00 pm - 6:20 pm | Steve Long (Memorial Sloan Kettering Cancer Center, USA) "Structure and Insights into the Mechanism of the Bestrophin Calcium-Activated Chloride Channel" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Brad Rothberg (Temple University School of Medicine, USA) "An Intersubunit Ca2+ Bridge Contributes to BK Channel Gating" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Irina Serysheva (The University of Texas Medical School, USA) "Cryo-EM Structure of the IP3R1 Channel: Insights into the Gating Mechanism" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Manuel Arcangeletti (International School for Advanced Studies (SISSA), Italy) "Interactions Between the C-Linker and the S4-S5 Linker Mediate Gating in CNGA1 Channels" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Nieng Yan (Tsinghua University, China) "Molecular Visualization of the Excitation-Contraction Coupling" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Ligand-Gated Ion Channels |
| Discussion Leader: Anna Moroni (University of Milan, Italy) |
9:00 am - 9:20 am | Pierre-Jean Corringer (Pasteur Institute, France) "Gating Mechanism of a Bacterial Homolog of Pentameric Ligand-Gated Ion Channel" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Jorg Grandl (Duke University, USA) "Mechanism of Activation and Modulation of Piezo Ion Channels" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Peter Hegemann (Humboldt-Universitaet zu Berlin, Germany) "Operation of Light as Ligand for Channel and Enzyme Activation" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Andrea Saponaro (University of Milan, Italy) "HCN Channel Modulation: The Competition Between cAMP and TRIP8b Explained in Molecular Detail" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:30 am | Henning Stahlberg (University of Basel, Switzerland) "A Prokaryotic Potassium Channel in Lipid Membranes Studied by Electron Crystallography" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Martina Rangl (INSERM U1006, France) "Real-Time Visualization of Conformational Changes in Ion Channels and Transporters by High-Speed Atomic Force Microscopy" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Eduardo Perozo (University of Chicago, USA) "On Symmetry and the Gating Mechanism of Ion Channels" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Technique Innovation |
| Discussion Leader: Simon Scheuring (INSERM U1006 / Aix-Marseille Université, France) |
6:00 pm - 6:20 pm | Gebhard Schertler (Paul Scherrer Institute / ETH Zürich, Switzerland) "The Application of Free Electron Lasers to Biology: A New Age of Time-Resolved Crystallography" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Carol Robinson (Oxford University, United Kingdom) "Membrane Proteins - The Lipid Connection" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:10 pm | Marina Casiraghi (IBPC Institut de Biologie Physico-Chimique, France) "Functional Remodelling of a GPCR Conformational Landscape in a Lipid Bilayer" |
7:10 pm - 7:15 pm | Discussion |
7:15 pm - 7:35 pm | Maxime Dahan (Institut Curie, France) "Unraveling the Diffusivity and Energy Landscapes of Membrane Proteins with High Density Single Molecule Imaging" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Hervé Rémigy (FEI Company, The Netherlands) "Cryo-TEM: A Third Member Joins the High Resolution Band" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Permeation and Gating Mechanisms in Ion Channels and Transporters |
| Discussion Leader: Kenton Swartz (National Institutes of Health, USA) |
9:00 am - 9:20 am | Ann McDermott (Columbia University, USA) "Allosteric Coupling in KcsA: Ion Affinities by SSNMR" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Bert de Groot (Max Planck Institute for Biophysical Chemistry, Germany) "The Molecular Dynamics of Selective Permeation Across Biological Channels" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Colin Nichols (Washington University School of Medicine in St. Louis, USA) "Lipid Control of Ion Channels: smFRET and Crystallography Reveal the Intimate and Moving Details" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Francisco Bezanilla (University of Chicago, USA) "Following the Movement of the Charges in Voltage Sensors" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Thomas Baukrowitz (University of Kiel, Germany) "A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Jian Payandeh (Genentech, USA) "Cryo-What? Engineering Human Voltage-Gated Sodium Channels for Crystallography and Structure-Based Drug Design" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Simon Berneche (Swiss Institute of Bioinformatics, Switzerland) "The Proton Pathway in a ClC H+/Cl- Antiporter" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Dual Function and Exotic Channels and Transporters |
| Discussion Leader: Poul Nissen (Aarhus University, Denmark) |
6:00 pm - 6:20 pm | Christopher Miller (Brandeis University, USA) "Binding of Two Funky Ligands to One Weird Channel" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Julia Preobraschenski (Max Planck Institute for Biophysical Chemistry, Germany) "Vesicular Glutamate Transporters (VGLUTs) Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Alessio Accardi (Weill Cornell Medical College, USA) "Ion and Lipid Transport by TMEM16 Phospholipid Scramblases" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:35 pm | Jean-Ju Chung (Yale University, USA) "Ca2+ Signaling Components in Sperm Motility and Fertility" |
7:35 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Joel Meyerson (Brandeis University, USA) "Structural Mechanism of Glutamate Receptor Activation and Desensitization" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Transporter Mechanism |
| Discussion Leader: Cristina Paulino (University of Zurich, Switzerland) |
9:00 am - 9:20 am | Olga Boudker (Weill Cornell Medical College, USA) "Controlling Transporter Dynamics and Function" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:45 am | Oezkan Yildiz (Max Planck Institute of Biophysics, Germany) "Citrate Recognition, Binding, and Transport by the Sodium-Dependent Citrate Symporter" |
9:45 am - 9:50 am | Discussion |
9:50 am - 10:10 am | Jose Faraldo-Gomez (National Institutes of Health, USA) "Molecular Mechanism of the Na+/Ca2+ Exchanger: Insights from Computations and Experiments" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Werner Kuhlbrandt (Max-Planck-Institute for Biophysics, Germany) "Structure and Mechanisms of Archaeal Sodium/Proton Antiporters" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Homa Majd (MRC Mitochondrial Biology Unit, United Kingdom) "A High Throughput Method for Identification of Orphan Mitochondrial Transporters" |
11:35 am - 11:40 am | Discussion |
11:40 am - 12:00 pm | Dirk Jan Slotboom (University of Groningen, The Netherlands) "Toppling Mechanism of Energy Coupling Factor Vitamin Transporters" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Andrea Brueggemann (Nanion Technologies, Germany) "Novel Approaches to Study Ion Channels and Transporters" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Late-Breaking Topics |
| Discussion Leader: Chris Ahern (University of Iowa, USA) |
6:00 pm - 6:20 pm | Dimitrios Stamou (University of Copenhagen, Denmark) "Insights Gained from the First Measurements of Transport at the Single Molecule Level" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:40 pm | Marcel Goldschen-Ohm (University of Wisconsin-Madison, USA) "Single Molecule Ligand Binding Dynamics at Micromolar Concentrations in Zero-Mode Waveguides" |
6:40 pm - 6:45 pm | Discussion |
6:45 pm - 7:05 pm | Filippo Mancia (Columbia University, USA) "Structure of a Micronutrient Transporter" |
7:05 pm - 7:15 pm | Discussion |
7:15 pm - 7:25 pm | Jiafei Mao (Biomolecular Magnetic Resonance Center (BMRZ), Goethe-University Frankfurt, Germany) "Understanding Ligand Selectivity of GPCR Subtypes – A View of Peptide Ligands from Solid-State Nuclear Magnetic Resonance (SSNMR) Spectroscopy Enhanced by Dynamic Nuclear Polarization (DNP)" |
7:25 pm - 7:30 pm | Discussion |
7:30 pm - 7:50 pm | Paul Shaffer (Amgen, Inc., USA) "Crystal Structures of the Glycine Receptor" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |