Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structural Mechanisms of Gating and Signalling
Discussion Leader: Edmund Kunji (MRC Mitochondrial Biology Unit, University of Cambridge, United Kingdom)
7:40 pm - 8:00 pm
Eric Gouaux (Vollum Institute, Oregon Health and Science University, USA)
"Structures of AMPA Receptor-TARP Complexes and Mechanism of Gating"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Nieng Yan (Princeton University, USA)
"Snapshots of the Voltage-Gated Sodium Channels"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Kurt Wüthrich (ETH Zurich, Switzerland / The Scripps Research Institute, USA)
"Comprehensive NMR View of Signaling-Related Structural Dynamics of the A2A Adenosine Receptor"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Channel Diversity
Discussion Leader: Nieng Yan (Princeton University, USA)
9:00 am - 9:20 am
Cristina Paulino (University of Groningen, The Netherlands)
"Cryo-EM Structure of TMEM16A: How Lipid Scramblases Grow up to Become Ion Channels"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Raimund Dutzler (University of Zurich, Switzerland)
"Activation Mechanism of the Ca2+ -Activated Cl- Channel TMEM16A"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Mei Hong (Massachusetts Institute of Technology, USA)
"Structural Dynamics and Cholesterol Binding of the Influenza M2 Protein from Solid-State NMR"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jian Yang (Columbia University, USA)
"Structures of the Endolysosomal Calcium Channel TRPML3 in Three Distinct States Reveal Mechanisms of Activation and Regulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Katsuhiko Mikoshiba (RIKEN Brain Science Institute, Japan)
"IP3 Receptor: IP3-Gated Ca2+ Channel"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Irina Serysheva (University of Texas Health Science Center at Houston, USA)
"Cryo-EM Studies of IP3R1: Towards Understanding the Mechanisms of Ligand-Binding and Channel Gating"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Crina Nimigean (Weill Cornell Medicine, USA) and Cristina Paulino (University of Groningen, The Netherlands)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanistic Studies
Discussion Leader: Kaspar Locher (ETH Zurich, Switzerland)
7:30 pm - 7:50 pm
Lucy Forrest (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Recent Insights into the Transport Cycle of a Sodium-Coupled Symporter"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Simon Scheuring (Weill Cornell Medicine, USA)
"High-Speed Atomic Force Microscopy (HS-AFM): Direct Visualization of Conformational Changes in Ligand Gated Ion Channels"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Andre Bazzone (Nanion Technologies GmbH, Germany)
"H+ Coupling and pH Regulation in MFS Sugar Transporters: An Application of SSM-Based Electrophysiology"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Janice Robertson (The University of Iowa, USA)
"Tuning the Stability of CLC Dimerization by Changing the Lipid Solvent"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Jacob Keller (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Transporter Function Measured by Quantitative Functional Imaging"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cation Channels
Discussion Leader: Raimund Dutzler (University of Zurich, Switzerland)
9:00 am - 9:20 am
Ming Zhou (Baylor College of Medicine, USA)
"Mechanism of Gating in an ATP-Gated Bacterial Cation Channel"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Henry Colecraft (Columbia University, USA)
"Designer Genetically-Encoded Ion Channel Modulators"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Richard Hite (Memorial Sloan Kettering Cancer Center, USA)
"Structural Titration of a Potassium Channel"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Crina Nimigean (Weill Cornell Medicine, USA)
"Ligand Gating in Potassium Channels"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Bonnie Wallace (Birkbeck, University of London, United Kingdom)
"The Role of Domain Interactions in the Opening and Closing of Voltage-Gated Sodium Channels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Liz Carpenter (University of Oxford, United Kingdom)
"Structure and Function of Ion Channels Involved in Human Genetic Disease"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Primary Active Transporters
Discussion Leader: Susan Buchanan (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
7:30 pm - 7:50 pm
John Walker (University of Cambridge, United Kingdom)
"Pores and Channels in the ATP Synthase in Mitochondria"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Soung-Hun Roh (Stanford University, USA)
"The 3.5 Ã… Cryo-EM Structure of Nanodisc Reconstituted Yeast Vacuolar ATPase Vo Proton Channel"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Zhe Zhang (The Rockefeller University, USA)
"Structural Studies of Cystic Fibrosis Transmembrane Conductance Regulator by Cryo-EM"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Kaspar Locher (ETH Zurich, Switzerland)
"Structure and Mechanism of Human Multidrug Transporter ABCG2"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Amer Alam (ETH Zurich, Switzerland)
"Structural Analysis of Drug Transport Inhibition in ABCB1"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
G-Protein Coupled Receptor-Mediated Signalling
Discussion Leader: Christopher Tate (Medical Research Council, United Kingdom)
9:00 am - 9:20 am
Daniel Oprian (Brandeis University, USA)
"Structure, Function, and Evolution of Retinylidene Proteins"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Patrick Sexton (Monash University, Australia)
"Towards a Structural Understanding of Peptide Ligand Recognition and Activation of Class B G Protein-Coupled Receptors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Franz Hagn (Technical University of Munich, Germany)
"Ligand and G-Protein-Induced Allosteric Structural Changes of a Stabilised Neurotensin Receptor Probed by Solution-State NMR"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Roger Sunahara (University of California, San Diego, USA)
"G Protein-Coupled Receptors as Allosteric Sensors Connecting Hormone Binding and Cations to G Proteins: Implications to Drug Discovery of Small Molecules"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Ali Jazayeri (Heptares Therapeutics, United Kingdom)
"Structural Elucidation of Class B G Protein-Coupled Receptors"
11:35 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Brian Kobilka (Stanford University, USA)
"Structural Insights into the Dynamic Process of G Protein-Coupled Receptor Activation"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Physiology and Pharmacology
Discussion Leader: Dirk Jan Slotboom (University of Groningen, The Netherlands)
7:30 pm - 7:50 pm
Lily Jan (University of California, San Francisco, USA)
"Calcium-Activated Chloride Channel"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Amy Newman (National Institute on Drug Abuse Intramural Research Program, NIH, USA)
"Translating the Atypical Dopamine Uptake Inhibitor Hypothesis from Structure to Function"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Hoangdung Ho (Genentech, USA)
"Structural Basis for Small Molecule Inhibition of an ABC Transporter"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Randy Stockbridge (University of Michigan, USA)
"Primal Function of the Small Multidrug Resistance (SMR) Family"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Small Molecule and Ion Transport
Discussion Leader: Liz Carpenter (University of Oxford, United Kingdom)
9:00 am - 9:20 am
David Drew (Stockholm University, Sweden)
"Lipids, Oligomerization and Energetics in Sodium/Proton Antiporters"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Cedric Govaerts (Universite Libre de Bruxelles, Belgium)
"Structure of LmrP Reveals Molecular Basis of Multidrug Recognition"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Joanne Parker (University of Oxford, United Kingdom)
"Structural Basis of Nucleotide Sugar Transport Across the Golgi Membrane"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Tetiana Serdiuk (ETH Zurich, Switzerland)
"Unravelling the Stepwise Insertion and Folding Mechanisms of Transmembrane Transporters by Insertases and Translocons "
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Hartmut Luecke (Nordic Center for Molecular Medicine, University of Oslo, Norway)
"Helicobacter Pylori pH Acclimation: The Evil Duo of a pH-Gated Urea Channel and a Cytoplasmic Urease"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Maria Falzone (Weill Cornell Graduate School of Medical Sciences, USA)
"Lipid Regulation of Scrambling by TMEM16 Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
H. Ronald Kaback (University of California, Los Angeles, USA)
"LacY: From Membrane to Molecule to Mechanism"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leader: Alessio Accardi (Weill Cornell Medicine, USA)
7:30 pm - 7:50 pm
Osamu Nureki (University of Tokyo, Japan)
"Ligand Recognition and Activation Mechanisms of Peptide and Lipid Recognizing G Protein-Coupled Receptor"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Henriette Autzen (University of California, San Francisco, USA)
"Structure of the Human TRPM4 Ion Channel in a Lipid Nanodisc"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Simon Newstead (University of Oxford, United Kingdom)
"Structural Basis of Amino Acid Transport by the CAT Family of SLC7 Transporters"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Gebhard Schertler (Paul Scherrer Institute / ETH Zurich, Switzerland)
"The Active Rhodopsin-G-Protein Complex Revealed by Cryo-EM and Crystallography"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Hayden Schmidt (Harvard Medical School, USA)
"The Structural Basis for Sigma-1 Receptor Ligand Recognition "
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Thomas Clairfeuille (Genentech Inc., USA)
"High Resolution Structure of a Novel Membrane Protein-Lipid Complex Essential for Bacterial Cell Growth"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure