Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Integrating Structures in Physiology
Discussion Leader: Randy Stockbridge (University of Michigan, United States)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
Andrew Marks (Columbia University, United States)
"Structure of RyR2 Channels Reveals a Mechanism for Exercise-Induced Sudden Death and it's Treatment"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Joseph Mindell (NINDS, United States)
"Fat Chances: How Signaling Lipids Influence Lysosomal pH via the Chloride Transporter ClC-7"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Janina Sörmann (University of Oxford, United Kingdom)
"Defective X-gating caused by de novo gain-of-function mutations in KCNK3 underlies a developmental disorder with sleep apnea"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Nancy Carrasco (Vanderbilt University, United States)
"Twenty-Five Years of the Sodium/Iodide Symporter (NIS): From its Cloning to..."
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Gating
Discussion Leader: Crina Nimigean (Weill Cornell Medicine, United States)
9:00 am - 9:20 am
Inga Hänelt (Goethe University Frankfurt, Germany)
"Regulation of Potassium/Proton Symporter KimA by Second Messenger Cyclic Di-AMP"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Whitney Stevens-Sostre (University of Wisconsin-Madison, United States)
"An Intracellular Hydrophobic Nexus is Critical for Slow Deactivation in hERG Channels"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Eduardo Perozo (University of Chicago, United States)
"Prestin’s Conformational Cycle and the Molecular Basis of Electromotility in Outer Hair Cells"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Kenton Swartz (National Institutes of Health, United States)
"Structure of the Shaker Kv Channel and Mechanism of C-Type Inactivation"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Franziska Heydenreich (MRC Laboratory of Molecular Biology, United Kingdom)
"Molecular Origins and Principles Governing Adrenaline Efficacy and Potency in the Human ß2-Adrenergic Receptor"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Robert Tampé (Goethe University Frankfurt, Germany)
"Cellular Machineries in Adaptive Immunity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Karen Fleming (Johns Hopkins University, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel Approaches to Investigate Membrane Protein Structure and Function
Discussion Leader: Simon Scheuring (Weill Cornell Medicine, United States)
6:00 pm - 6:20 pm
Andreas Plueckthun (University of Zurich, Switzerland)
"Novel Engineering Strategies and Structural and Mechanistic Insights into GPCRs"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Prashant Rao (OHSU, United States)
"The Structural and Molecular Composition of Native AMPA Receptor Complexes"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Chris Ahern (University of Iowa, United States)
"Decoding the Language of Aromatic Side-Chains in Ion Channels and Receptors"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Willow Coyote-Maestas (University of California, San Francisco, United States)
"Deconvoluting Membrane Protein Trafficking, Folding, and Function by Multi-Parametric Mutational Scanning"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Olga Boudker (Weill Cornell Medicine, United States)
"19F NMR Maps Conformational Ensembles of Membrane Transporters"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structural Insights in Membrane Protein Function
Discussion Leader: Eva Cunha (University of Oslo, Norway)
9:00 am - 9:20 am
Yifan Cheng (Howard Hughes Medical Institute/UC San Francisco, United States)
"Structural Snapshots of TRPV1 in Response to Stimuli"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Anna Borowska (University of Groningen, The Netherlands)
"The Conformational Heterogeneity of a Human Neutral Amino Acid Transporter"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Xiaochun Li (University of Texas Southwestern Medical Center, United States)
"Molecular Basis of Lipid-Mediated GPCR Activation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Nicolas Reyes (National Center of Scientific Research CNRS, France)
"Transport and Receptor Mechanisms of a Solute Carrier"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Show-Ling Shyng (Oregon Health and Science University, United States)
"Structural Mechanisms of Ligand Regulation in KATP Channels"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Sigrid Noreng (Genentech, United States)
"Structure of the Core Human Phagocytic NADPH Oxidase NOX2"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Stephan Pless (University of Copenhagen, Denmark)
"The Curious Case of the Human Sodium Leak Channel"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathophysiology of Membrane Transport and Signaling
Discussion Leader: Henry Colecraft (Columbia University, United States)
6:00 pm - 6:20 pm
Gail Robertson (University of Wisconsin-Madison, United States)
"Coordinated Biogenesis and Regulation of Functionally Related Ion Channels"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Qin Yu (IMBB, ETH Zürich, Switzerland)
"Drug Transport and Modulation of ABCG2 Activity by 2nd Generation of Ko143 Derivatives"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Crina Nimigean (Weill Cornell Medicine, United States)
"Ligand and Lipid Modulation in Cyclic Nucleotide-Gated Channels"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Katarzyna Drozdzyk (University of Zurich, Switzerland)
"Cryo-EM Structures of CALHM Channels of the Human Placenta"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Gaia Novarino (Institute of Science and Technology Austria (ISTA), Austria)
"Role of the SLC7A5 Transporter in Cortical Neuron Maturation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein-Membrane Interactions
Discussion Leader: Simon Newstead (University of Oxford, United Kingdom)
9:00 am - 9:20 am
Karen Fleming (Johns Hopkins University, United States)
"Hydrophobicity Along the Z-Dimension of the Bilayer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Randy Stockbridge (University of Michigan, United States)
"Substrate Specify vs. Promiscuity in the Small Multidrug Resistance Family of Transporters"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Poul Nissen (Aarhus University, Denmark)
"Structure and Function of Autoregulatory Mechanisms of P-Type ATPases"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Roderick MacKinnon (Rockefeller Unv/Howard Hughes Medical Institute, United States)
"Force Transduction in Piezo Ion Channels"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Oliver Adams (University of Oxford, United Kingdom)
"Cryo-EM Structure and Resistance Landscape of M. tuberculosis MmpL3: An Emergent Therapeutic Target"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Camilo Perez (University of Basel, Switzerland)
"Mechanism of Cell Wall Transporters Involved in Teichoic Acids Synthesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Structural Pharmacology
Discussion Leader: Olga Boudker (Weill Cornell Medicine, United States)
6:00 pm - 6:20 pm
Jue Chen (Howard Hughes Medical Institute/Rockefeller University , United States)
"How Small Molecules Improve CFTR Folding"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Damian Bell (Sophion Bioscience, Denmark)
"Automated Patch Clamp and Antivenom Discovery"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Marta Filizola (Icahn School of Medicine at Mount Sinai, United States)
"Unleashing the Power of Enhanced Molecular Dynamics Simulations and Artificial Intelligence for Structure-Based Drug Discovery"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Elizabeth Kim (Weill Cornell Medicine, United States)
"Identification of HCN1 allosteric sites for small molecule modulation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Vera Moiseenkova-Bell (University of Pennsylvania, United States)
"TRPV Channels Gating by Endogenous and Exogenous Modulators"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Structural Dynamics
Discussion Leader: Anna Moroni (University of Milan, Italy)
9:00 am - 9:20 am
Joshua Levitz (Weill Cornell Medicine, United States)
"Mechanisms of Activation and Regulation of Metabotropic Glutamate Receptors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Janina Stautz (Goethe University Frankfurt, Germany)
"Allosteric regulation of KtrAB by nucleotides"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Lucie Delemotte (Science for Life Laboratory, Sweden)
"Conformational Sampling of Sugar Porters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
Ina Urbatsch (Texas Tech University Health Sciences Center, United States)
"Site-Specific Tryptophan Fluorescence Distinguishes Drug-Binding to Distinct Sites of the Multidrug Exporter P-Glycoprotein"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
Daniel Minor (University of California, San Francisco, United States)
"A Through the Looking Glass View of Voltage-Gated Ion Channel Structure"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Simon Scheuring (Weill Cornell Medicine, United States)
"TRPV2 Intrinsically Disordered Regions (IDRs) mediate Protein-Protein Interactions"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Ryan Gumpper (UNC Chapel Hill, United States)
"Molecular Insights into Serotonin-2A Receptor Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Late-Breaking Topics
Discussion Leader: Kaspar Locher (ETH Zurich, Switzerland)
6:00 pm - 6:20 pm
Nami Tajima (Case Western Reserve University, United States)
"Structural Basis of Ionotropic Glutamate Receptor Gating and Allosteric Modulation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Jose Velilla (Harvard University, United States)
"Structural Basis of Colibactin Activation by the ClbP Peptidase"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Volodymyr Korkhov (Paul Scherrer Institute / ETH Zurich, Switzerland)
"Structure and Function of Membrane Adenylyl Cyclases"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Leonid Sazanov (Institute of Science and Technology Austria, Austria)
"Structure and Mechanism of the Cation/Proton Antiporter Complex MRP"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Filippo Mancia (Columbia University, United States)
"Molecular Mechanisms Underlying Omega-3 Fatty Acid Uptake Across the Blood-Brain Barrier"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure