Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Mechanisms of Membrane Transport
Discussion Leader: Camilo Perez (ETH Zurich, Switzerland)
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
Dirk Jan Slotboom (University of Groningen, The Netherlands)
"Mechanisms of Membrane Transport"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms of Transporters
Discussion Leader: Shashank Pant (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:45 pm
Antoniya Aleksandrova (National Institute of Neurological Disorders and Stroke, NIH, USA)
"All-EncoMPASSing – A Comprehensive Dataset of Symmetries in Membrane Protein Structures"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Joury van 't Klooster (University of Groningen, The Netherlands)
"Lipid Dependent Activity of an APC-Family Plasma Membrane Transporter from S. cerevisiae "
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Yuhang Wang (University of Illinois at Urbana-Champaign, USA)
"Osmotic Pressure Sensing/Regulation Through Lipid-Protein Interactions in the LeuT-Fold Secondary Active Membrane Transporter BetP"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Paola Bisignano (University of California, San Francisco, USA)
"Inhibitor Binding Modes and Allosteric Modulation in Sodium-Glucose Symporters"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Jonathan Coleman (Oregon Health and Science University, USA)
"Structural Studies of the Serotonin Transporter Reveals Mechanism of Drug Inhibition"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Loick Lancien (ETH Zurich, Switzerland)
"Structure and Function of a Human Liver ABC Transporter"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Molecular Mechanisms of Channels and Receptors
Discussion Leader: Eva Cunha (Max Planck Institute for Biophysics, Germany)
9:00 am - 9:15 am
Daniele Di Marino (Università della Svizzera italiana, Switzerland)
"Unravelling the Inactive Conformation of the G Protein Bile Acid Receptor (GP-BAR1) Through the Binding Characterisation of a New Potent Antagonist Molecule"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Naomi Latorraca (Stanford University, USA)
"Molecular Mechanism of GPCR-Mediated Arrestin Activation"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Jeffrey Liu (Max Planck Institute of Biochemistry, Germany)
"In Vivo Brain GPCR Signaling Elucidated by Phosphoproteomics"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Thomas Clairfeuille (Genentech Inc, USA)
"High-Resolution Structure of a Novel Membrane Protein-Lipid Complex Essential for Bacterial Cell Growth"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Andres Jara-Oseguera (National Institute of Neurological Disorders and Stroke, NIH, USA)
"The Role of the Selectivity Filter in Gating of the TRPV1 Channel"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Johannes Vierock (Humboldt University of Berlin, Germany)
"Temporal Evolution and Molecular Determinants of Proton Conductance in Channelrhodopsins"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Advice
Discussion Leader: Ryan Henderson (University of Groningen, The Netherlands)
1:30 pm - 2:15 pm
Susan Buchanan (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Let's Start at the Beginning: A Career in Membrane Protein Structure Determination"
2:15 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
