Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Lipidomics in Decoding Biology
Discussion Leader: William Griffith (Swansea University Medical School, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
Vytas Bankaitis (texas a&m university, United States)
"Lipid Exchange Proteins and Regulation of Phosphoinositide Signaling"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
William Holland (University of Utah, United States)
"Familial Hyperceramidemia in Diabetes and End-Stage Renal Disease"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Federica Ferrentino (King's college london, United Kingdom)
"Lipidomic Changes Impact the Morphology of the Endoplasmic Reticulum"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Nils Hoffmann (IBG-5, Forschungszentrum Jülich GmbH, Germany)
"LipidCompass - A Reference Database for Quantitative Lipidomics"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipidomics in Human Health and Disease
Discussion Leader: Edward Dennis (University of California, San Diego, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Michal Holcapek (University of Pardubice, Czech Republic)
"Early Detection of Pancreatic Cancer Based on Blood Lipidome: Translation from Academic Laboratory into Clinical Screening"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Michael Kiebish (Berg, LLC, United States)
"Interrogating Human Biology to Discover Novel Signaling Lipid Drivers of Metabolism as Well as Disease Intervention"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Jung Suh (Denali Therapeutics, United States)
"Tauopathy Stroking the Flames of ApoE4 Toxicity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Mélanie Plourde (Université de Sherbrooke, Canada)
"Lipidomics of the Lateral Ventricle Choroid Plexus during Aging"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Yuqin Wang (Swansea University, United Kingdom)
"Sterols as Lipid Biomarkers for Huntington’s Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Shreyoshi Chakraborti (Stony Brook University, United States)
"Understanding the Role of Lipids in the Mechanism of Action of melH , a Key Regulator of Oxidative Stress in Mycobacterium Tuberculosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Arieh Moussaieff (The Hebrew University, Israel)
"Lipid Desaturation Regulates the Balance between Self-renewal and Differentiation in Blastocyst-derived Stem Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Erin Baker (University of North Carolina, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Harmonization and Standardization in Lipidomics
Discussion Leader: Valerie O'Donnell (Cardiff University, United Kingdom)
7:30 pm - 8:00 pm
Markus Wenk (National University of Singapore, Singapore)
"Variabilities and Reference Ranges of Human Blood Plasma Lipids"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Laura Goracci (University of Perugia, Italy)
"From Lipostar to Lipostar 2: New Tools and Workflows for LC-MS Based Untargeted Lipidomics"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
Jeffrey McDonald (UT Southwestern Medical Center, United States)
"Defining the Lipidomics Minimal Reporting Checklist to Establish Harmony, Quality, and Transparency"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Gerhard Liebisch (University Hospital Regensburg, Germany)
"Lipidomics Minimal Reporting Checklist"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Lipidomic Mass Spectrometry Strategies
Discussion Leader: System.String[]
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
André Nadler (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Imaging Lipid Flux on Subcellular Scales"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Boone Prentice (University of Florida, United States)
"Identification of Isobaric and Isomeric Lipids in Imaging Mass Spectrometry Using Gas-Phase Ion/Ion Reactions"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Group Photo / Coffee Break
10:50 am - 11:20 am
Christoph Thiele (University of Bonn, Germany)
"Multiparallel Alkyne Lipid Tracing to Study the Dynamics of Triglyceride Storage"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Kyle Saunders (University of Surrey, United Kingdom)
"Optimization of Single Cell Lipidomics Using Nanocapillary Sampling and Mass Spectrometry"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Xin Ma (Georgia Institute of Technology, United States)
"Spatially Resolved Lipidomic Profiling of Ovarian Cancer Using Ultrahigh Resolution Mass Spectrometry Imaging"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Laura Bailey (University of Florida, United States)
"Reinvention and Validation of the Sulfo-Phospho-Vanillin Assay for Sample Normalization in Quantitative Lipidomic LC-MS/MS"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Ingela Lanekoff (Uppsala University, Sweden)
"Isomeric Differentiation of Silver Cationized Lipids using Direct Infusion and MSn"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Clinical and Translational Lipidomics
Discussion Leader: Dawn Dufield (KCAS, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Daisuke Saigusa (Teikyo University, Japan)
"Lipidomic Profiling in the Large-Scale Cohort for Biomarker Discovery and the Importance of Separation Science"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Peter Åkerblad (Albireo Pharma, Sweden)
"A3907 a Clinical Systemically Available ASBT Inhibitor – Lipidomic Fingerprinting of NASH Models Translating to Effects in Humans"
8:45 pm - 8:55 pm
Discussion
9:35 pm - 9:45 pm
Cecile Gladine (INRAE, France)
"The Plasma Oxylipin Signature Provides a Fine Phenotyping of Metabolic Syndrome Complementary to the Clinical Criteria"
9:45 pm - 9:50 pm
Discussion
9:50 pm - 10:00 pm
Valerie O'Donnell (Cardiff University, United Kingdom)
"How to Follow Accepted International Practice for Analysis of Small Molecules when Analyzing Oxylipins"
10:00 pm - 10:05 pm
Discussion
10:05 pm - 10:10 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipidomics Data Dimensions and Biological Interpretation
Discussion Leader: John McLean (Vanderbilt Universtiy, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Erin Baker (University of North Carolina, United States)
"Fingerprinting How Lipids are Affected by Exposure with LC-IMS-CID-MS"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Steffany Bennett (University of Ottawa, Canada)
"Aberrant Sphingolipid and Phospholipid Metabolism are Defining Dementia Pathologies that Discriminate Cognitively Normal Aging from Alzheimer’s Disease and Dementia with Lewy Bodies"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Andrej Shevchenko (MPI of Molecular Cell Biology and Genetics, Germany)
"Tissue Lipidomics by Ultra-High Resolution Mass Spectrometry"
11:25 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Xue Li Guan (Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore)
"Microbial Lipids - A Greasy Business"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kelly Hines (University of Georgia, United States)
"RPLC-IM-MS to Monitor Host-Derived Lipid Utilization by Staphylococcus Aureus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Resolving Lipid Metabolic Networks
Discussion Leader: Gavin Reid (University of Melbourne, Australia)
5:30 pm - 5:35 pm
Introduction by Discussion Leader
5:35 pm - 6:05 pm
Charles Serhan (Harvard University, United States)
"Human Neutrophils and Macrophages Biosynthesize Cell Type Specific Resolvins from the 4S,5S-epoxy-Resolvin Intermediate that Regulate Inflammation-Resolution, Tissue Regeneration, and Granuloma Formation"
6:05 pm - 6:15 pm
Discussion
6:15 pm - 6:45 pm
Nathan Hatcher (Merck & Co., Inc., United States)
"Unraveling Complex Lipid Biology using Stable Isotopically Labeled Tracer-Based Assays"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:25 pm
Jace Jones (University of Maryland, School of Pharmacy, United States)
"Diacyl and Ether Glycerophosphoethanolamine Oxidation Susceptibility Following Lipid Peroxidation: Application to Traumatic Brain Injury"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Role of the Environment on the Lipidome
Discussion Leader: Nancy Denslow (University of Florida, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Laila Abdullah (Roskamp Institute, United States)
"APOE4 Mediated Disruption of the L-Carnitine System Contributes to Bioenergetic Deficits in Neurological Disorders"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Jeremy Koelmel (Julius Sun, United States)
"Dynamic Environment, Dynamic Lipidome: Probing System Wide Lipid Changes Using Novel Software"
10:15 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Kuniyuki Kano (The University of Tokyo, Japan)
"Visualization of Phospholipid Metabolism Based on MS Imaging Technology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Michiel Vandenbosch (Maastricht University, The Netherlands)
"Quantitative Mass Spectrometry Imaging to Study Lipid Metabolism in Parkinson’s Disease Model"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kaylie Kirkwood (North Carolina State University, United States)
"Elucidating Lipid Dysregulation in Mice Exposed to Various Perfluoroalkyl Substances (PFAS) with Multidimensional Measurements"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ken Stark (University of Waterloo, Canada)
"Lipidomic Biomarkers of Dietary Omega-3 Polyunsaturated Fatty Acids"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Dolma Michellod (MPI for marine microbiology, Germany)
"Phytosterol Synthesis within the Animal Kingdom"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integration of Lipidomics with Genomics, Proteomics and Metabolomics
Discussion Leader: Vladimir Capka (Senda Biosciences, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Bjoern Titz (Philip Morris International R&D, Switzerland)
"Lipidomics in Multi-Omics Toxicology and Disease Studies"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
Peter Meikle (Baker Heart and Diabetes Institute, Australia)
"Comprehensive Genetic Analysis of the Human Lipidome Identifies Novel Loci Controlling Lipid Homeostasis with Links to Coronary Artery Disease"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
Miroslava Cuperlovic-Culf (National Research Council of Canada, Canada)
"Gaussian Process Regression Selection of Principal Distance Correlation Partners for Determination of Lipidomics and Metabolomics Network Changes in Acute COVID-19 Infection"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Patrycja Puchalska (UMN, United States)
"Artifactual FA Dimers Mimic FAHFA Signals in Untargeted Metabolomics Pipelines"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure