| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | HDL Apolipoprotein Structure-Function |
| Discussion Leader: Mary Sorci-Thomas (Wake Forest University School
of Medicine) |
| 7:30 pm - 8:10 pm | Mary Sorci-Thomas (Wake Forest University School of Medicine)
"Lipid-Bound Conformation of Apo A-I on Discs vs. Spheres: Helix Registry and Conformational States" |
| 8:10 pm - 8:50 pm | Frank Peelman (Ghent University, Belgium)
"Mechanism of LCAT Activation by Apo A-I" |
| 8:50 pm - 9:30 pm | Giovanna Chimini (Centre d'Immunologie, Marseille, France)
"ABCA1 Function Dictates Apo A-I Docking to the Cell Surface" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Genetics and In vivo Regulation of HDL Metabolism and Reverse Cholesterol Transport |
| Discussion Leader: Daniel Rader (University of Pennsylvania) |
| 9:00 am - 9:45 am | Robert Hegele (University of Western Ontario)
"Genetics of Variation in HDL in Humans" |
| 9:45 am - 10:30 am | Beverly Paigen (Jackson Labs)
"Genetics of Variation in HDL in Mice" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Daniel Rader (University of Pennsylvania)
"Lipases in HDL Metabolism and Reverse Cholesterol Transport" |
| 11:45 am - 12:30 pm | Theo van Berkel (University of Leiden, Holland)
"SR-BI and ABCA1 Regulation of in Vivo HDL Metabolism" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Niemann-Pick Type C Disease and Intracellular Trafficking of Cholesterol |
| Discussion Leader: T.Y. Chang (Dartmouth Medical School) |
| 7:30 pm - 8:00 pm | Shigeki Sugii (Dartmouth Medical School)
"Cholesterol Trafficking in NPC1 Mutant Cells" |
| 8:00 pm - 8:30 pm | Yiannis Ioannou (Mount Sinai School of Medicine)
"The NPC1 Permease and Subcellular Lipid Transport" |
| 8:30 pm - 8:45 pm | Steve Sturley (University of Columbia)
"The Primordial Role of NPC1 Proteins: Sphingolipid Transport?" |
| 8:45 pm - 9:15 pm | Joan Blanchette-Mackie (NIDDK/NIH)
"Intracellular Trafficking of NPC1 and NPC2 Proteins" |
| 9:15 pm - 9:45 pm | Jerome Strauss (University of Pennsylvania)
"START Domain Proteins and the NPC1 Compartment" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Reverse Cholesterol Transport |
| Discussion Leader: George Rothblat (Children's Hospital of Philadelphia) |
| 9:00 am - 9:40 am | George Rothblat (Children's Hospital of Philadelphia)
"Cellular Cholesterol Efflux" |
| 9:40 am - 10:25 am | David Williams (State University of New York at Stony Brook)
"New Insights into the Function of Scavenger Receptor B1" |
| 10:25 am | Coffee Break |
| 10:50 am - 11:35 am | Monty Krieger (Massachusetts Institute of Technology)
"Scavenger Receptor B1 and Reverse Cholesterol Transport" |
| 11:35 am - 12:20 pm | Omar Francone (Pfizer Research)
"The Role of ABCA1 in Atherosclerosis: Insights from Knockout Mice" |
| 12:20 pm - 12:30 pm | Adam Seegmiller (University of Texas Southwestern Medical Center)
"Regulation of SREBP Processing and Membrane Lipid Production by Phosphatidylethanolamine in Drosophila" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Insulin Resistance and Hyperlipidemia |
| Discussion Leader: Henry Ginsberg (Columbia University) |
| 7:30 pm - 8:10 pm | Henry Ginsberg (Columbia University)
"Links Between Insulin Resistance and Increased VLDL Secretion" |
| 8:10 pm - 8:50 pm | Frederic Kraemer (Stanford University)
"Regulation of Adipocyte Lipolysis by Hormone Sensitive Lipase" |
| 8:50 pm - 9:30pm | Philipp Scherer (Albert Einstein College of Medicine, New York)
"Acrp 30/adiponectin: Role in Systemic Insulin Sensitivity, Glucose and Lipid Metabolism" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Nuclear Receptors and Lipoprotein Metabolism |
| Discussion Leader: Peter Edwards (University of California at Los Angeles) |
| 9:00 am - 9:45 am | Peter Edwards (University of California at Los Angeles)
"The Effect of Activation of FXR and LXR on Plasma and Bile" |
| 9:45 am - 10:30 am | Peter Tontonoz (University of California at Los Angeles)
"Nuclear Receptor Signaling Pathways in Atherosclerosis" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Joyce Repa (University of Texas Southwestern Medical Center)
"The Role of Nuclear Receptors in Regulating Lipid Homeostasis" |
| 11:45 am - 12:30 pm | Bruce Spiegelman (Harvard University)
"Regulation of Energy Balance by PPARgamma and its Coactivators" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lipid Metabolism in the Brain |
| Discussion Leader: Ulrike Beisiegel (Hamburg University, Germany) |
| 7:30 pm - 8:00 pm | Ulrike Beisiegel (Hamburg University, Germany)
"Lipoprotein Metabolism in the Brain" |
| 8:00 pm - 8:30 pm | John Dietschy (University of Texas Southwestern Medical Center)
"Net Cholesterol Balance Across the Brain" |
| 8:30 pm - 9:00 pm | Joachim Herz (University of Texas Southwestern Medical Center)
"Apo E Receptors in the Brain" |
| 9:00 pm - 9:30 pm | Thomas Perlmann (Karolinska Institute, Stockholm, Sweden)
"Retinoids and Other Fatty Acids Activating Nuclear Receptors in the Central Nervous System" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Genomics and the Study of Lipid Metabolism |
| Discussion Leader: Deborah Nickerson (University of Washington, Seattle) |
| 9:00 am - 9:45 am | Deborah Nickerson (University of Washington, Seattle)
"SNPing Genes Involved in Lipid Metabolism" |
| 9:45 am - 10:30 am | Jonathan Cohen (University of Texas Southwestern Medical Center)
"Genetic Analysis of Plasma Lipid Levels" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Len Pennacchio (Lawrence Berkeley National Laboratory)
"Apolipoprotein A -V and Plasma Triglyceride Levels in Humans and Mice" |
| 11:45 am - 12:30 pm | Derek Symula (David Axelrod Institute for Public Health, Albany)
"Mutagenesis Approaches to Identify New Genes Involved in Lipid Metabolism" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:00 pm | Keynote Address |
| 7:30 pm - 9:00 pm | H. Bryan Brewer (National Heart, Lung and Blood Institute)
"Tangier Disease - Pitfalls and Epiphanies Along the Way from Clinical Phenotype to Genotype and the Discovery of the ABC Transporters" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
