| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Human Genetics of Lipoprotein Metabolism |
| Discussion Leader: Robert Hegele |
| Robert Hegele (University of Western Ontario)
"The Genetics of Lipodystrophy and Insulin Resistance" |
| Jonathan Cohen (Univ Texas Southwestern)
"Role of ARH in LDL receptor endocytosis" |
| Catherine Boileau (Hopital Necker-Enfansts Malades, Paris)
"Autosomal Dominant Hypercholesterolemia due to mutations in Narc-1" |
| Nabil Seidah (IRCM, Montreal)
"Implication of the proprotein convertases in lipid/sterol metabolism" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Photo |
| 9:00 am - 12:30 pm | HDL Structure and Metabolism |
| Discussion Leader: Mary Sorci-Thomas |
| David Silver (Columbia University School of Medicine)
"PDZK1 in the regulation of HDL metabolism" |
| John Parks (Wake Forest University School of Medicine)
"The Role of Hepatic ABCA1 in HDL Formation and Catabolism" |
| Mary Sorci-Thomas (Wake Forest University School of Medicine)
"Inflammation and Inhibition of Reverse Cholesterol Transport" |
| Ronald Barbaras (Institut Claude de Preval, Toulouse, France)
"Is the ectopic ATP synthase in human hepatocytes a new pathway in the HDL metabolism?" |
| W. Sean Davidson (University of Cincinnati Medical Center)
"New Methods for Understanding HDL Apoprotein Structure" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lipid synthesis and transport |
| Discussion Leader: Robert Farese |
| Robert Farese (Gladstone Institute)
"DGAT enzymes and triglyceride synthesis" |
| Jay Horton (UT Southwestern)
"Fatty acid elongases" |
| Harry Davis (Schering Plough)
"Role of NPC1L1 in Cholesterol Absorption and the Activity of Ezetimibe" |
| Yiannis Iouannou (Mount Sinai)
"Role of NPC1L1 in Lipid Metabolism and Atherosclerosis" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Regulation of adipocyte lipid metabolism |
| Discussion Leader: Karen Reue |
| Karen Reue (UCLA)
"Lipin: a new player in adipocyte lipid metabolism" |
| Dawn Brasaemle (Rutgers/State University of New Jersey)
"Adipocyte Lipid Droplet-Associated Proteins and the Control of Triacylglycerol Metabolism" |
| Stefan Offermanns (University of Heidelberg)
"The physiology and cell biology of the nicotinic acid receptor" |
| Hyo-Sung Ro (Dalhousie University)
"Role of AEBP1 in adipogenesis and atherogenesis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Nuclear Receptors and Lipid Metabolism |
| Discussion Leader: Jorge Plutzky |
| Joyce Repa (UT Southwestern)
"LXRs, ABCs and cholesterol homeostasis" |
| Jorge Plutzky (Brigham and Women's Hospital/Harvard Medical School)
"Endogenous mechanisms of PPAR regulation" |
| Steve Shoelson (Harvard University/Joslin Clinic)
"Transcriptional links between inflammation and metabolism" |
| Henry Ginsberg
"SREBP-independent hepatic lipogenesis in a mouse model of insulin resistance: role of PPARgamma2" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Macrophage lipid metabolism and inflammation |
| Discussion Leader: Alan Daugherty |
| Murray Huff (University of Western Ontario)
"Role of oxysterol synthesis in macrophage function" |
| Ellen Pure (University of Pennsylvania)
"Regulation of the macrophage inflammatory response by 15-lipoxygenase" |
| Junken Aoki (Tokyo University)
"Phosphatidyl-serine and phosphatidic acid-selective phospholipases" |
| Nancy Webb (University of Kentucky)
"The role of secretory phospholipases in lipoprotein metabolism and atherosclerosis" |
| Kathryn Moore (Harvard)
"CD36 and atherosclerosis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Address |
| Ronald Evans (The Salk Institute for Biological Studies)
"Nuclear receptors: Running away from obesity" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cellular signalling via lipoprotein receptors |
| Discussion Leader: Joachim Herz |
| Joachim Herz (UT Southwestern)
"Novel pathways for cell regulation by members of the LDL receptor gene family" |
| David Hui (University of Cincinnatti)
"Signalling by apoE in the regulation of vascular smooth muscle cells" |
| Xi He (Boston Children's/Harvard Medical School)
"LDL receptor related proteins and Wnt signaling" |
| Philip Shaul (UT Southwestern)
"Molecular Mechanisms of HDL Action in Endothelium" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cellular lipotoxicity |
| Discussion Leader: Steve Sturley |
| Steve Sturley (Columbia University)
"Cholesterol and fatty acid toxicity in yeast" |
| Jean Schaffer (Washington University)
"Lipotoxicity: getting to the heart of the matter" |
| Ira Tabas (Columbia University)
"The role of macrophage cholesterol in the unfolded protein response and apoptosis" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
