| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:15 pm - 7:30 pm | Welcoming comments |
| 7:30 pm - 9:30 pm | EMERGING ROLE OF LIPIDS IN DEVELOPMENT |
| Discussion Leader: Laura Woollett (University of Cincinnati)
|
| 7:30 pm - 7:50 pm | Robert D. Steiner (Oregon Health and Science University)
"Inborn errors of sterol synthesis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Laura Woollett (University of Cincinnati)
"Role of lipids in fetal tissues" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Thomas E. Willnow (Max-Delbrueck-Center for Molecular Medicine)
"Role of megalin/LRP2 in forebrain development" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | W. Scott Argraves (Medical University of South Carolina)
"Abnormalities in morphogenesis and HDL homeostasis in cubilin-deficient mice" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | APOLIPOPROTEIN STRUCTURE AND FUNCTION |
| Discussion Leader: Robert Ryan (Children’s Hospital of Oakland Research Institute) |
| 9:00 am - 9:20 am | Karl Weisgraber (Gladstone Institute)
"New Lessons from Apolioprotein E Structure" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sean Davidson (University Cincinnati)
"The structure and function of apolipoprotein A-IV" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Greg Shelness (Wake Forest University Health Sciences)
"Mechanisms of ApoB-dependent Lipid Mobilization and Secretion" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Robert Ryan (Children’s Hospital of Oakland Research Institute)
"Apolipoprotein A-V and triacylglycerol metabolism" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jere Segrest (University of Alabama, Birmingham)
"Structure and Dynamics of HDL" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Michael Oda (Children’s Hospital of Oakland Research Institute)
"ApoA-I: Functional insights from structural observations" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Sissel Lund-Katz (CHOPS)
"Novel Insights into Apolipoprotein E Molecular Interactions" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 5:30 pm - 6:30 pm | Dinner |
| 7:00 pm - 9:00 pm | HDL, INFLAMMATION AND OXIDATION IN ATHEROSCLEROSIS |
| Discussion Leader: Roland Stocker (University of New South Wales)
|
| 7:00 pm - 7:20 pm | Roland Stocker (University of New South Wales)
"Oxidation of lipoproteins in the vessel wall" |
| 7:20 pm - 7:30 pm | Discussion |
| 7:30 pm - 7:50 pm | Jay Heinecke (University of Washington)
"Site-specific oxidation of apoA-I by myeloperoxidase" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Phil Barter (The Heart Research Institute, Sydney, Australia)
"Inhibition of acute vascular inflammation by HDL" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Linda Curtiss (Scripps Institute)
"Specificity for Apo AI in Reverse Cholesterol Transport from Lesions" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm | Fireworks! |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | GENETIC DETERMINANTS OF LIPOPROTEIN TRANSPORT |
| Discussion Leader: Robert Hegele (University of Western Ontario) |
| 9:00 am - 9:25 am | Jake Lusis (UCLA)
"Toward a biologic network for lipid metabolism and atherosclerosis" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 10:00 am | Jonathan Smith (Cleveland Clinic)
"Identifying atherosclerosis susceptibility genes in mice" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:25 am | Robert Hegele (University of Western Ontario)
"Looking at lipid transport from a genomic perspective" |
| 10:25 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:25 am | Marten Hofker (Maastrict University)
"The role of inflammation in steatohepatis and lipid metabolism" |
| 11:25 am - 11:35 am | Discussion |
| 11:35 am - 12:00 pm | Jay Horton (University of Texas Southwest)
"PCSK9's Role in Determining Plasma Cholesterol Levels" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:25 pm | Ruth McPherson (University of Ottawa Heart Institute)
"Selective uptake: a tale of two receptors" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Judging |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | MECHANISMS OF HYPERLIPIDEMIA-INDUCED ATHEROSCLEROSIS |
| Discussion Leader: Alan Daugherty (University of Kentucky)
|
| 7:30 pm - 7:50 pm | Ira Tabas (Columbia University)
"The Cellular Biology of Macrophage Apoptosis in Advanced Atherosclerosis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Lynn Hedrick (University of Virginia)
"Molecular Mechanisms of Diabetic Atherosclerosis" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Alyssa Hasty (Vanderbilt University)
"Impact of obesity on lipoprotein metabolism and atherosclerosis" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Bruce Sachais (University of Pennsylvania)
"Involvement of platelet factor 4 in atherosclerosis" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Alan Daugherty (University of Kentucky)
"The angiotensin-hypercholesterolemia connection in the development of atherosclerosis" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | THE MOLECULAR PHYSIOLOGY OF HDL METABOLISM AND REVERSE CHOLESTEROL TRANSPORT |
| Discussion Leader: Daniel Rader (University of Pennsylvania) |
| 9:00 am - 9:20 am | Daniel Rader (University of Pennsylvania)
"Molecular regulation of macrophage reverse cholesterol transport" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Albert Groen (Amersterdam Academic Medical Center)
"The role of the liver and intestine in RCT" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Gerry Waters (Merck)
"Molecular pharmacology of nicotinic acid and its receptor" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Alan Tall (Columbia Univeristy)
"ABC Transporters and Lipid Efflux from Macrophages" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Peter Edwards (UCLA)
"ABCG1 controls tissue lipid homeostasis; lessons from null and transgenic mice" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Miranda Van Eck (Gorlaeus)
"Role of macrophage CETP and PLTP in lipoprotein metabolism and atherosclerosis" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Judging |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | REGULATION OF LIPOPROTEIN METABOLISM BY NUCLEAR HORMONE RECEPTORS |
| Discussion Leader: Murray Huff (University of Western Ontario)
|
| 7:30 pm - 7:50 pm | Bart Staels (Institut Pasteur de Lille)
"Metabolic control by lipid-activated nuclear receptors" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Joyce Repa (University of Texas Southwestern)
"LXRs and Lipid Efflux" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Murray Huff (University of Western Ontario)
"Selective activation of LXR-regulated genes by endogenous oxysterols attenuates foam cell formation" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jean Vance (University of Alberta, Canada)
"Cholesterol homeostasis in neurons and glial cells" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ABC TRANSPORTERS |
| Discussion Leader: John Parks (Wake Forest University) |
| 9:00 am - 9:20 am | Michael Philips (CHOPS)
"ABCA1-Mediated Efflux of Cellular Lipids and Formation of Nascent HDL Particles" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | John Parks (Wake Forest Health Sciences)
"ABCA1 in HDL formation" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Michael Hayden (University of British Columbia)
"ABC A1 function in the G IT and pancreas: Unexpected Journeys" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Kerry-Anne Rye (The Heart Research Institute, Sydney, Australia)
"Effects of glycation on the structure, function and anti-inflammatory properties of apoA-I" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Yves Marcel (University of Ottawa Heart Institute)
"Macrophage in hypoalphalipoproteinemia, a cell prone to inflammation" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Cheryl Wellington (University of British Columbia)
"ABC Transporters and Neurodegenerative Disease" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Ashley Vaughan (University of Washington)
"ABCA1 and ABCG1 contribute to the removal of excess cholesterol from loaded macrophages" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Viewing |
| 6:00 pm | Awards Dinner |
| 7:00 pm - 7:30 pm | Awards |
| 7:30 pm - 9:30 pm | LIPID UPTAKE AND STORAGE |
| Discussion Leader: Ira Goldberg (Columbia University)
|
| 7:30 pm - 7:50 pm | Ira Goldberg (Columbia University)
"Cardiac uptake of lipoprotein lipids" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Nada Abumrad (Washington University)
"Role of the CD36-FoXO1 interaction in regulating energy transitions in muscle" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Perry Bickel (Washington University)
"Packaging and trafficking of intracellular neutral lipids" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Rudi Zechner (University Graz)
"ATGL, the rate-limiting enzyme for the catabolism of stored fat in peripheral tissues" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Ling Li (University of Alabama, Birmingham)
"Apolipoprotein A-I: from Heart to Brain" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
