| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:45 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:45 pm - 9:30 pm | HDL Structure and Function |
| Discussion Leader: Mary Sorci-Thomas (Wake Forest University) |
| 7:45 pm - 8:05 pm | Stan Hazen (Lerner Research Institute, Cleveland Clinic)
"Structural insights into HDL maturation and dysfunction" |
| 8:05 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:35 pm | Mary Sorci-Thomas (Wake Forest University)
"Three dimensional models of high density lipoprotein apo A-I: Implications for its assembly, maturation and function" |
| 8:35 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Michael N. Oda (Children’s Hospital of Oakland Research Institute)
"Structure of apo A-I on HDL subclasses" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Jay W. Heinecke (University of Washington)
"The protein universe of lipoproteins" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Genomics of Lipoprotein Metabolism |
| Discussion Leader: Helen H. Hobbs (University of Texas Southwestern Medical Center) |
| 9:00 am - 9:25 am | Helen Hobbs (University of Texas Southwestern Medical Center)
"Rare mutations in complex diseases: not so rare and not so complex" |
| 9:25 am - 9:40 am | Discussion |
| 9:40 am - 10:05 am | Jonathan C. Cohen (University of Texas Southwestern Medical Center)
"Population-based resequencing: covering all the bases" |
| 10:05 am - 10:20 am | Discussion |
| 10:20 am | Coffee Break / Group Photo |
| 10:50 am - 11:10 am | Len A. Pennacchio (Lawrence Berkeley National Laboratory)
"Insights from deep resequencing in humans" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 11:40 am | Sekar Kathiresan (Massachusetts General Hospital and Broad Institute)
"Common DNA sequence variants, blood lipids, and myocardial infarction" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:10 pm | A. Jake Lusis (University of California Los Angeles)
"A network-centered view of cardiovascular traits" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Lipoproteins and Atherosclerosis |
| Discussion Leader: Alan Daugherty (University of Kentucky) |
| 7:30 pm - 7:50 pm | Alan Daugherty (University of Kentucky)
"Interactions of hypercholesterolemia and the renin angiotensin system" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Alyssa H. Hasty (Vanderbilt University Medical Center)
"Macrophage TLR4 expression modulates macrophage accumulation in both atherosclerotic lesions and white adipose tissue" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Miranda van Eck (University of Leiden)
"Role of macrophage cholesterol transporters in atherosclerosis" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Larry Chan (Baylor College of Medicine)
"Adipose differentiation related protein: foam cell formation and atherosclerosis" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Lipoproteins and Cell Biology of the Vessel Wall |
| Discussion Leader: Ira Tabas (Columbia University) |
| 9:00 am - 9:20 am | Ira Tabas (Columbia University)
"Macrophage apoptosis in advanced atherosclerosis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Jan Borén (University of Göteborg)
"Subendothelial lipoprotein retention" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | J. Mark Brown (Wake Forest University)
"Inhibition of SCD-1 dissociates insulin resistance & obesity from atherosclerosis" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Edward A. Fisher (New York University School of Medicine)
"The regression of atherosclerosis: roles of lipid efflux, LXR and foam cell migration from plaques" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Catherine C. Hedrick (University of Virginia)
"Lipid Signaling in Cells of the Arterial Wall" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Patrick C. Rensen (Leiden University Medical Center)
"Torcetrapib and atherosclerosis in the APOE*3-Leiden.CETP mouse" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Shobha Ghosh (Virginia Commonwealth University)
"Macrophage cholesterol homeostasis at the cross roads of Atherosclerosis and Inflammation" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Regulation of Adipocyte Function |
| Discussion Leader: Karen Reue (University of California Los Angeles) |
| 7:30 pm - 7:50 pm | Karen Reue (University of California Los Angeles)
"The lipin family: bi-functional proteins in adipogenesis and metabolism" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Miklos Péterfy (Cedars-Sinai Medical Center)
"LMF1, a new gene in hypertriglyceridemia" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Ruth McPherson (Ottawa Heart Institute)
"Genetics of Adiposity & Leanness" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Dawn L. Brasaemle (Rutgers University)
"Lipid droplet-associated proteins and triacylglycerol metabolism" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Intestinal Lipoprotein Metabolism and Processing |
| Discussion Leader: Stephen Young (University of California Los Angeles) |
| 9:00 am - 9:20 am | Stephen G. Young (University of California Los Angeles)
"GPIHBP1, a new player in lipolysis" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Lawrence L. Rudel (Wake Forest University)
"Molecular events of intestinal cholesterol metabolism" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:10 am | Erin E. Mulvihill (The University of Western Ontario)
"Naringenin corrects diet-induced metabolic disturbances in Ldlr-/- mice" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break |
| 10:45 am - 11:05 am | Robert O. Ryan (Children's Hospital Oakland Research Institute)
"Apolipoprotein mediated regulation of plasma lipid homeostasis" |
| 11:05 am - 11:15 am | Discussion |
| 11:15 am - 11:35 am | Jay D. Horton (University of Texas Southwestern Medical Center)
"PCSK9 and lipoprotein metabolism" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Timothy S. Fisher (Merck Research Laboratories)
"Functional analysis of sites within PCSK9 responsible for hypercholesterolemia" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Nabil G. Seidah (Clinical Research Institute of Montreal)
"Furin, PC5/6 and PCSK9 in health and disease" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Hot Topics in Lipoprotein Metabolism |
| Discussion Leader: Joyce J. Repa (University of Texas Southwestern Medical Center) |
| 7:30 pm - 7:50 pm | Joyce J. Repa (University of Texas Southwestern Medical Center)
"LXR and ChREBP: Bridging glucose and lipid homeostasis" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Gary F. Lewis (University of Toronto)
"Intestinal lipoprotein overproduction in insulin resistant states: Focus on human studies" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Maroun Bou Khalil (University of Ottawa)
"Lipin-1 expression controls assembly and secretion of hepatic VLDL" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 9:05 pm | Henry N. Ginsberg (Columbia University)
"Endoplasmic reticulum stress, VLDL secretion, and hepatic steatosis" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Cheryl L. Wellington (University of British Columbia)
"High density lipoproteins in the central nervous system" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Molecular Targets and New Therapeutics |
| Discussion Leader: Daniel J. Rader (University of Pennsylvania) |
| 9:00 am - 9:20 am | Daniel J. Rader (University of Pennsylvania)
"New therapies for dyslipidemia" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Richard Lee (ISIS Pharmaceuticals)
"Antisense oligonucleotide-mediated inhibition of apolipoprotein B" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Kevin Fitzgerald (Alnylam)
"RNAi therapeutics targeting PCSK9" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Harry R. Davis (Schering-Plough Pharmaceuticals)
"Role of NPC1L1 in cholesterol trafficking and atherosclerosis" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | John S. Parks (Wake Forest University)
"Macrophage ABCA1, inflammation, and insulin resistance" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jacques Genest Jr (McGill University)
"A novel compound, RVX208 raises HDL-C and apo A-I" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Michael R. Hayden (University of British Columbia)
"From genes to therapy - LPL to the rescue" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Special State-of-the art and future vision session |
| Discussion Leaders: Alan R. Tall (Columbia University) and Jan Breslow (The Rockefeller University) |
| 7:30 pm - 8:00 pm | Alan R. Tall (Columbia University)
"ABC transporters, sterol efflux and atherogenesis" |
| 8:00 pm - 8:15 pm | Discussion |
| 8:15 pm - 8:45 pm | Jan Breslow (The Rockefeller University)
"State-of-the-art and future of research in lipoprotein metabolism" |
| 8:45 pm - 9:00 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
