SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | The Control of Lipolysis in Plasma |
| Discussion Leader: Stephen G. Young (UCLA) |
7:40 pm - 8:00 pm | Stephen G. Young (UCLA)
"New insights into lipolysis of triglyceride-rich lipoproteins"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Gunilla Olivecrona (Umea University)
"Post-translational modulation of lipoprotein lipase" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Murray Huff (University of Western Ontario)
"Prevention of VLDL overproduction, dyslipidemia, insulin resistance, inflammation and atherosclerosis by citrus flavonoids"
|
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Michael N. Oda (CHORI)
"HDL structure - Is this a clinically relevant objective?" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Regulation of Cholesterol Homeostasis |
| Discussion Leader: Russell Debose-Boyd (UT Southwestern) |
9:00 am - 9:30 am | Margrit Schwarz (Amgen)
"PCSK9 inhibitors for LDL-C lowering"
|
9:30 am - 9:40 am | Discussion |
9:40 am | Group Photo / Coffee Break |
10:30 am - 10:50 am | Kate Rayner (University of Ottawa Heart Institute)
"MicroRNA regulation of lipoprotein metabolism"
|
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Peter Tontonoz (UCLA)
"Nuclear receptor control of cholesterol homeostasis"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Marisa Wong Medina (CHORI)
"Alternative Splicing in Regulation of Cholesterol Homeostasis"
|
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Russell Debose-Boyd (UT Southwestern)
"New players in the sterol-regulated HMG CoA reductase degradation pathway"
|
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | High-density Lipoprotein: Impact of Particle Diversity |
| Discussion Leader: Mary Sorci-Thomas (Wake Forest University) |
7:30 pm - 7:50 pm | Alan Tall (Columbia University)
"The role of ABC transporters in regulating hematopoietic stem and progenitor cell proliferation, monocytosis, thrombocytosis and atherosclerosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Sean Davidson (University of Cincinnati)
"Apolipoprotein interactions within HDL particles"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Jay Heinecke (University of Washington)
"Pathways for the generation of dysfunctional HDL"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Daisy Sahoo (Medical College of Wisconsin)
"BiFC-FRET: Progress on a novel method to visualize SR-BI oligomerization in vivo"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Apolipoprotein B and TG Rich Lipoprotein Assembly |
| Discussion Leader: Henry Ginsberg (Columbia University) |
9:00 am - 9:30 am | Zemin Yao (University of Ottawa)
"Lumenal lipid droplets as the determinant of VLDL secretion and microsome stress"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Edward Fisher (NYU School of Medicine)
"Regulation Of Vldl Secretion: Roles Of Insulin And Cholesteryl Ester Hydrolysis"
|
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:10 am - 11:40 am | Gregory Shelness (Wake Forest School of Medicine)
"Regulation of hepatic apoB particle expansion and triglyceride transport by apoA-IV"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Ira Goldberg (Columbia University)
"Taking lipid imbalance to heart" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Expanding Functions of LDL Receptor Family Members |
| Discussion Leader: Joachim Herz (UT Southwestern) |
7:30 pm - 8:10 pm | Joachim Herz (UT Southwestern)
"Signaling through LRP-1 protection from atherosclerosis"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Bart Williams (University of Michigan)
"Assessing the Roles of Lrp5 and Lrp6 in Development and Disease"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Petra May (University of Freiburg,Germany)
"The LDL receptor-related protein 1 functions as a signaling receptor in inflammation and development"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lipids, ABC Transporters, and Disease |
| Discussion Leader: Yves Marcel (University of Ottawa) |
9:00 am - 9:20 am | Elizabeth Tarling (UCLA)
"New insights into the role of ABCG1 in sterol homeostasis and lipid oxidation"
|
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Mary Sorci-Thomas (Wake Forest University)
"Cholesterol Efflux, Microdomains and the Role of ApoA-I in Chronic Inflammation and Atherosclerosis" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:50 am | John Parks (Wake Forest University)
"Tissue-specific roles of ABCA1 in lipoprotein metabolism and atherosclerosis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Cheryl Wellington (University of British Columbia)
"Lipoprotein Metabolism in the Central Nervous System"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Ira Tabas (Columbia University)
"Lipids, ER stress, and mitochondrial dysfunction in atherosclerosis"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Therapy to Treat Cardiovascular Disease |
| Discussion Leader: Daniel J. Rader (University of Pennsylvania) |
7:30 pm - 8:00 pm | Daniel J. Rader (University of Pennsylvania)
"Functional validation of new genes associated with plasma lipoproteins"
|
8:00 pm - 8:05 pm | Discussion |
8:05 pm - 8:35 pm | Douglas G. Johns (Merck)
"Emerging Therapies in Atherosclerosis"
|
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Roger Newton (Esperion) |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Norman Wong (Resverlogix)
"The Target by which RVX-208 increases ApoA-I production" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Intracellular Lipid Transport and Lipid Droplet Biology |
| Discussion Leader: Robert Farese, Jr. (Gladstone Institute, UCSF) |
9:00 am - 9:30 am | Tobias Walther (Yale University)
"Cell Biology of Cellular Fat Synthesis and Storage"
|
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Jean Schaffer (Washington University)
"Small nucleolar RNAs as mediators of lipid metabolic stress"
|
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
11:10 am - 11:40 am | Meng Wang (Baylor College of Medicine)
"Modeling lipid dynamics via label-free stimulated Raman scattering microscopy"
|
11:40 am - 11:50 am | Discussion |
11:50 am - 12:00 pm | Jonathan Smith (Cleveland Clinic)
"Recent insights into the mechanism of ABCA1 mediated HDL biogenesis" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Robert Farese Jr. (Gladstone Institutes / UCSF)
"Identification of a homozygous DGAT1 mutation in humans" |
12:15 pm - 12:20 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | State of the Art: Genomics, Proteomics and Metabolomics |
| Discussion Leader: Philippa Talmud (University College London) |
7:30 pm - 7:40 pm | Philippa Talmud (University College London)
"The two things about cardiovascular genetics" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:10 pm | Robert Hegele (University of Western Ontario)
"Complex genetics of hypertriglyceridemia" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Christopher R. McMaster (Dalhousie University)
"Using High-thoughput Synthetic Genetics to Integrate Phospholipid Metabolism with Regulation of Cellular Processes" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Chris Newgard (Duke University)
"Metabolomics used for defining metabolic disease mechanisms" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |