SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:20 pm - 7:25 pm | Welcome / Introductory Comments by GRC Site Staff |
7:25 pm - 7:35 pm | Welcome Address by Chairs Robert V. Farese, Jr. (Gladstone/UCSF) and Joachim J. Herz (UTSW) |
7:35 pm - 9:30 pm | Lipases |
| Discussion Leader: Rudolf Zechner (University of Graz, Austria) |
7:35 pm - 8:05 pm | Rudolf Zechner (University of Graz, Austria) |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Perry Bickel (UTSW)
"A Lipid Droplet Protein Doubles as a Transcriptional Coregulator of Mitochondrial Function"
|
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:15 pm | Jorge Plutzky (Harvard)
"Programmatic Control of Gene Expression in Metabolism and Inflammation" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Hepatic and Intestinal Lipid Metabolism |
| Discussion Leader: Jay Horton (UTSW) |
9:00 am - 9:30 am | Jay Horton (UTSW)
"Post-Transcriptional Regulation of Fatty Acid Synthesis"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Steven Kliewer (UTSW)
"Physiology and Pharmacology of Metabolic Hormone FGF21"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Group Photo / Coffee Break |
10:50 am - 11:20 am | Carlos Fernandez-Hernando (Yale)
"Identification of Novel Regulators of LDL Receptor Pathway Using Genome-Wide RNAi Cellular Screens"
|
11:20 am - 11:35 am | Discussion |
11:35 am - 12:05 pm | Chih-Hao Lee (Harvard)
"Hepatic Control of Peripheral Lipid Metabolism"
|
12:05 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | HDL and Reverse Cholesterol Transport |
| Discussion Leader: Peter Edwards (UCLA) |
7:30 pm - 8:00 pm | Thomas Vallim (UCLA)
"Transcriptional Control of Cholesterol Catabolism"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Mark Brown (Cleveland Clinic)
"Novel Mechanisms Regulating Non-Biliary Reverse Cholesterol Transport"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Marina Cuchel (University Pennsylvania)
"Assessing In Vivo Reverse Cholesterol Transport: From Mice to Humans"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lipoprotein Receptors, Inflammation, and the Vascular Wall |
| Discussion Leader: Joachim Herz (UTSW) |
9:00 am - 9:30 am | Ira Tabas (Columbia)
"Receptor-Mediated Pathways of Inflammation Resolution in Atherosclerosis"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Philippe Boucher (University of Strasbourg)
"An LRP1/Wnt Signaling Pathway for Intracellular Cholesterol Homeostasis"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:20 am | Philip Shaul (UTSW)
"Endothelial Cell Biology of LRP8/ApoER2"
|
11:20 am - 11:35 am | Discussion |
11:35 am - 12:05 pm | Andreas Niemeier (University of Hamburg)
"Emerging Functions of Lipoprotein Receptors and Apolipoprotein E in the Skeleton" |
12:05 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | CNS and Lipids |
| Discussion Leader: Cheryl Wellington (University of British Columbia) |
7:30 pm - 8:00 pm | Cheryl Wellington (University of British Columbia)
"HDL in the Central Nervous System: More than apoE"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | David Holtzman (Washington U.)
"Potential Role of apoE in Both Amyloid-Beta and Tau Metabolism In Vivo"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Emily Osterweil (University Edinburgh)
"Lovastatin for the Treatment of Neurodevelopmental Disorders"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Intracellular Lipid Metabolism |
| Discussion Leader: Tobias Walther (Yale) |
9:00 am - 9:30 am | Tobias Walther (Yale)
"Mechanisms of Intracellular Lipid Storage in Droplets"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Peng Li (Tsinghua U.)
"Control of Lipid Droplet Fusion by CIDE Proteins"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:20 am | Anders Naar (Harvard)
"MicroRNA Regulation of Cholesterol/Lipid and Energy Homeostasis"
|
11:20 am - 11:35 am | Discussion |
11:35 am - 12:05 pm | Jin Ye (UTSW)
"Lipid Metabolism in Cancer Development and Treatment"
|
12:05 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Short Talks / Keynote Talk on Lipid and Lipoprotein Metabolism |
| Discussion Leader: Robert V. Farese, Jr. (Gladstone/UCSF) |
7:30 pm - 7:40 pm | Short Talk: Amnon Schlegel (University Utah) |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 7:55 pm | Ryan Temel (University of Kentucky)
"Species-Specific Regulation of Plasma LDL Levels by the LXR-Idol Pathway"
|
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Abigail Haka (Weill Cornell Medical College)
"TLR4 Signaling Regulates a Novel Form of Aggregated LDL Endocytosis"
|
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 9:15 pm | Keynote: Dan Rader (University Penn) |
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genetics of Lipid and Lipoprotein Metabolism |
| Discussion Leader: Daniel Rader (University Pennsylvania) |
9:00 am - 9:30 am | Jake Lusis (UCLA)
"Systems Genetics of Lipoproteins"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Alan Shuldiner (University Maryland)
"Genomics of Lipoprotein Metabolism: Lessons from a Founder Population"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:50 am - 11:20 am | Karen Reue (UCLA)
"Molecular Basis of Lipin-Related Diseases"
|
11:20 am - 11:35 am | Discussion |
11:35 am - 12:05 pm | Sekar Kathiresan (Harvard)
"Impact of Human Gene Knockouts on Lipoproteins and Risk for Myocardial Infarction" |
12:05 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Therapeutics of Lipid and Cardiovascular Disease |
| Discussion Leader: Stephen Previs (Merck) |
7:30 pm - 7:50 pm | Alan Remaley (NIH)
"Recombinant Lecithin:Cholesterol Acyltransferase for the Treatment of Familial LCAT Deficiency and Cardiovascular Disease" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Rosanne Crooke (Isis)
"Targeting Cardiovascular Risk Factors with Second Generation Antisense Oligonucleotides"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Amy Simon (Alnylam) |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Debora Keefe (Novartis) |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |