Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Pathways in Cellular Lipid Homeostasis in the Brain and Other Tissues
Discussion Leader: Kiran Musunuru (University of Pennsylvania, USA)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:45 pm
Peter Tontonoz (University of California, Los Angeles, USA)
"New Pathways in Cellular Lipid Homeostasis"
8:45 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Peter Hecker (University of Kentucky, USA)
"Intracranial Atherosclerosis in Nonhuman Primates Promotes a Neuroinflammatory Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Cynthia Traughber (Lerner Research Institute, Cleveland Clinic, USA)
"CRISPR Gene Editing to Elucidate the Roles of HDL Metabolizing Receptors SR-B1 and ABCA1 in the Regulation of Prostate Cancer Cell Proliferation"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipoprotein Metabolism in the Brain
Discussion Leader: Joachim Herz (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:25 am
Oleg Butovsky (Brigham and Women's Hospital / Harvard University, USA)
"Dual Faces of Dr. Jekyll Microglia: Degenerating Neurons Cannot 'Hyde'"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Gayathri Ramaswamy (Biogen Inc., USA)
"Regulation of ApoE in the Central Nervous System"
10:00 am - 10:10 am
Discussion
10:10 am - 10:45 am
Group Photo / Coffee Break
10:45 am - 11:10 am
Maki Tsujita (Nagoya City University Graduate School of Medical Sciences, Japan)
"ABCG1/ABCG4 Modulates Amyloid Beta Production in the Central Nervous System"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
Jason Ulrich (Washington University in St. Louis, USA)
"ApoE Facilitates the Microglial Response to Amyloid Pathology"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Melissa Brereton (Washington University in St. Louis, USA)
"A Mechanism for Lipid Binding to Apolipoprotein E"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Gut Microbiota and Intestinal Lipid Metabolism
Discussion Leader: Rebecca Haeusler (Columbia University, USA)
7:30 pm - 7:55 pm
J. Mark Brown (Lerner Research Institute, Cleveland Clinic, USA)
"Therapeutic Targeting of Gut Microbial Enzymes for the Treatment of Cardiometabolic Disease"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Marc-Emmanuel Dumas (Imperial College London, United Kingdom)
"The Microbial-Host Crosstalk in Cardiometabolism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Thomas Vallim (University of California, Los Angeles, USA)
"Novel Mechanisms Controlling Bile Acid Metabolism in Health and Disease"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Luca Pellegrini (Université Laval, Canada)
"Structural and Functional Participation of the Mitochondria-Wrapping Rough-ER (WrappER) in VLDL Biogenesis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tissue Engineering: New Human Experimental Platforms for the Study of Metabolic Disease
Discussion Leader: Alan Remaley (National Institutes of Health, USA)
9:00 am - 9:25 am
Alison Kohan (University of Connecticut, USA)
"Intestinal Organoids for Examining Lipid Absorption and Lipoprotein Secretion"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jerome Robert (University of British Columbia, Canada)
"Clearance of Beta-Amyloid Is Facilitated by ApoE and Circulating HDL"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Takanori Takabe (Cincinnati Children's Hospital, USA)
"Modelling Steatosis and Fibrosis in Human Vascularized Organoids"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:40 am
Sara Vasconcelos (University Health Network, Canada)
"Bioengineering Approaches Towards Vascular Regeneration"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Cayla Rodia (University of Connecticut, USA)
"Lipid Provisioning Modifies Treg Metabolism to Protect Against Colitis"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Diego Lucero (National Heart, Lung, and Blood Institute, NIH, USA)
"Role of Fluid Phase Endocytosis in Interleukin-10 Induced HDL and LDL Uptake in Macrophages"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genomics of Dementia and Cardiovascular Disease
Discussion Leader: Cheryl Wellington (University of British Columbia, Canada)
7:30 pm - 7:50 pm
Haiming Cao (National Institutes of Health, USA)
"Regulation of Systemic Lipid Metabolism by Mouse and Human Long Noncoding RNAs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Muredach Reilly (Columbia University, USA)
"A Transcriptome Perspective on Human Genomics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Jose Vargas (MedStar Georgetown University Hospital, USA)
"Health Disparities in Genomic Medicine"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Szilard Voros (G3 - Global Genomics Group, USA)
"Leveraging Precision Phenotyping and Panomics to Unravel Novel Biology of Lipoprotein Metabolism and Atherosclerosis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
HDL Structure and Function
Discussion Leader: Mary Sorci-Thomas (Medical College of Wisconsin, USA)
9:00 am - 9:25 am
W. Sean Davidson (University of Cincinnati, USA)
"The Structure and Composition of Human HDL"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Amy Shah (Cincinnati Children's Hospital Medical Center / University of Cincinnati, USA)
"HDL Subspecies and Their Function: Risk Factors for Adolescent Onset Type 2 Diabetes"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Jonathan Smith (Cleveland Clinic, USA)
"Mechanism of HDL Biogenesis"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:40 am
Jerzy-Roch Nofer (University Hospital Muenster, Germany)
"Sphingosine 1-Phosphate (S1P) Signaling in Macrophages: Role in Atherosclerosis, Insulin Resistance and Beyond"
11:40 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Alex Bashore (Wake Forest School of Medicine, USA)
"Hepatocyte Abca1 Recycles Plasma High Density Lipoprotein Cholesterol (HDL-C), Reducing HDL-C Reverse Cholesterol Transport"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Sarah Proudfoot (Medical College of Wisconsin, USA)
"Working out the Kinks of SR-BI-Mediated Cholesterol Transport"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
ApoB-Containing Lipoprotein Metabolism and Cellular Uptake Pathways
Discussion Leader: M. Mahmood Hussain (NYU Winthrop Hospital, USA)
7:30 pm - 7:50 pm
Gabor Csanyi (Augusta University, USA)
"The Macrophage Drinking Problem Behind Atherosclerosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Gordon Francis (University of British Columbia, Canada)
"Smooth Muscle Cell Contribution to Excess Cholesterol Accumulation and Implications for Regression of Atherosclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Saskia Neher (University of North Carolina at Chapel Hill, USA)
"Putting Misfolded LPL in Its Place"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Gissette Reyes-Soffer (Columbia University Medical Center, USA)
"Effects of Novel Treatments on ApoB-Containing Lipoproteins"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Novel Therapies and Diagnostic Approaches for Vascular Lipoprotein Disorders
Discussion Leader: Sudha Biddinger (Boston Children's Hospital, USA)
9:00 am - 9:30 am
James Otvos (LabCorp, USA)
"Accounting for HDL-Inflammation Interaction Unmasks HDL Disease Relations"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
Anna Schwendeman (University of Michigan, USA)
"Synthetic HDL-Mediated Delivery of LXR Agonist Promotes Atherosclerosis Regression"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Norman C.W. Wong (University of Calgary, Canada)
"Benefits of Selective Inhibition of Epigenetic BET Proteins in Cardiovascular Disease"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
Samuel Wright (CSL Behring, USA)
"HDL Infusion Therapy with CSL-112"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Selected Poster Presentations / Late-Breaking Topics
Discussion Leader: Marlys Koschinsky (Robarts Research Institute, Canada)
5:30 pm - 5:40 pm
Alexandra Chadwick (University of Pennsylvania, USA)
"CRISPR-Cas9 Base Editing for Treatment of Atherogenic Dyslipidemia"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Kelly Manthei (University of Michigan, USA)
"Molecular Basis for Activation by a Small Molecule Activator of Lecithin:Cholesterol Acyltransferase (LCAT)"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Marieli Gonzalez Cotto (National Cancer Institute, NIH, USA)
"Trem-2 Supports the Metabolic Demands of Macrophage Alternative Activation"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:40 pm
Mary Sorci-Thomas (Medical College of Wisconsin, USA)
"SR-BI and PCPE2 Modulate Lipid Trafficking in Adipocytes"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:15 pm
Joachim Herz (University of Texas Southwestern Medical Center, USA)
"A Novel Therapeutic Approach for Multiple Sclerosis"
7:15 pm - 7:25 pm
Discussion
7:25 pm - 7:30 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure