Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Genetics of Lipids and Cardiovascular Disease
Discussion Leader: Marlys Koschinsky (Robarts Research Institute, Canada)
7:40 pm - 8:40 pm
Sekar Kathiresan (Verve Therapeutics, United States)
"Genetics of Lipoprotein Metabolism and Coronary Artery Disease"
8:40 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipoproteins and Apolipoproteins
Discussion Leader: Samar Hammad (Medical University of South Carolina, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ira Goldberg (New York University, United States)
"Lipoprotein Catabolism and Atherosclerosis in the Absence of Lipoprotein Lipase"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Judith Storch (Rutgers University, United States)
"Cholesterol Trafficking in the Endolysosomal System by NPC Proteins"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Nathalie Pamir (Oregon Health and Science University, United States)
"Lp(a), Plasminogen, and Cellular Sterol Regulation: Tip of the Iceberg"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Kasey Vickers (Vanderbilt Univ. Medical Center, United States)
"Plasminogen is an Alternative Lipoprotein with Diverse Cargo and Fibrin-independent Functions in Atherosclerosis-associated Inflammation"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Kendall Burks (Washington University in St. Louis School of Medicine, United States)
"ANGPTL3 Regulates Hepatic Lipoprotein Production: A New Model For Lipid Lowering?"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Marlys Koschinsky (Robarts Research Institute, Canada) and Daisy Sahoo (Medical College of Wisconsin, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Approaches to Modulate Plasma Lipids and Lipoproteins
Discussion Leader: Mary Sorci-Thomas (Medical College of Wisconsin, United States)
7:30 pm - 7:50 pm
Marina Cuchel (University of Pennsylvania, United States)
"Developing Gene Therapies for Dyslipidemia: What We've Learned From the Experience With HoFA"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Christie Ballantyne (Baylor College of Medicine, United States)
"siRNA Therapy for Lipid Modification"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sergio Fazio (Regeneron, United States)
"Monoclonal Antibodies for the Treatment of Dyslipidemia"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Danish Saleheen (Columbia University, NY, United States)
"Human Genetics to Validate Therapeutic Lipoprotein Targets"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Noncoding RNAs in Lipoprotein Metabolism and Modulation of Cardiovascular Diseases
Discussion Leaders: M. Mahmood Hussain (NYU Langone , United States)
9:00 am - 9:20 am
Tamer Sallam (University of California, Los Angeles, United States)
"RNA Dynamics in Metabolic Control"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Coen van Solingen (NYU Langone Medical Center, United States)
"The Multitudinous Roles of Non-Coding RNAs in Lipoprotein Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Abulaish Ansari (NYU Langone, United States)
"Role of miR-541-3p in the Regulation of LDL, HDL, and Atherosclerosis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
Adil Rasheed (University of Ottawa Heart Institute, Canada)
"MLKL (Mixed Lineage Kinase Domain-Like Protein): An Immunometabolic Nexus of Cardiovascular Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Aishah Al-Jarallah (Kuwait university, Kuwait)
"High Density Lipoprotein Reduces Blood Pressure and Protects Spontaneously Hypertensive Rats Against Myocardial Ischemia-Reperfusion Injury in an SR-BI Dependent Manner"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Giusy Della Gatta (Regeneron Pharma, United States)
"Identifying the Molecular Mechanisms Linking Changes of Glycosylation with Atherosclerosis Protection in B4galt1 Mouse Model"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Fang Li (Columbia University Irving Medical Center, United States)
"Elucidating the Variant-to-function Relationship for LIPA, a Risk Locus of Coronary Artery Diseases"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mart Reimund (National Institutes of Health, United States)
"Short Hydrocarbon-Stapled ApoE Mimetic Peptides Enhance Lipoprotein Uptake"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipid Metabolism in Adipose Tissue
Discussion Leader: Gary Schwartz (Albert Einstein College of Medicine, United States)
7:30 pm - 7:50 pm
Robert Farese (Harvard T.H. Chan School of Public Health, United States)
"Mechanisms and Physiology of Lipid Droplet Formation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Susan Fried (Icahn School of Medicine at Mount Sinai, United States)
"Mechanisms Promoting the "Safe" Storage of Triglycerides in Adipocytes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Sujith Rajan (NYU Langone Health, United States)
"Role of MTP in Adipocyte Lipid Hydrolysis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Sander Kersten (Wageningen University, The Netherlands)
"Role and Regulation of ANGPTL4 in Human Adipose Tissue"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Post-Genomic Era in Lipoprotein Metabolism
Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, United States)
9:00 am - 9:20 am
Robert Bauer (Columbia University, United States)
"Functional Validation of the 19q13 Plasma Lipid GWAS Locus Implicates the Transcription Factor C/EBPa"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Noam Zelcer (Academic Medical Center of the University of Amsterdam, The Netherlands)
"Empowering Mammalian Haploid Genetics to Identify Novel Genes and Pathways in Lipid Metabolism"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Thomas Vallim (University of California, Los Angeles, United States)
"LDLR and GOLIATH: Regulation of Lipoprotein Metabolism"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
James Pirruccello (Broad Institute, United States)
"Machine Learning Enables New Insights into Genetic Contributions to Liver Fat Accumulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jan Albert Kuivenhoven (UMCG Pediatrics, Molecular Genetics, The Netherlands)
"Using Contextual Co-Expression Analysis to Increase Insight in the Biogenesis of ApoB-Containing Lipoproteins"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Antoine Rimbert (French Institute of Health and Medical Research (INSERM), France)
"Genome-Wide Association Studies Linking Plasma and Hepatic Lipids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Permanent Modification of Lipid Levels
Discussion Leader: Daisy Sahoo (Medical College of Wisconsin, United States)
7:30 pm - 7:50 pm
Xiao Wang (University of Pennsylvania, United States)
"Genome Editing and Epigenome Editing of Lipid Genes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Klaus Ley (Augusta University, United States)
"ApoB-Specific CD4 T Cells in Mouse and Human Atherosclerosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Steven Farber (Carnegie Institution for Science/ Johns Hopkins University, United States)
"Is it Ever Wise to Edit Wild-Type Alleles? Engineered CRISPR Alleles Versus 2 Million Years of Human Evolution"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Anjali Owens (Perelman School of Medicine at the University of Pennsylvania, United States)
"The Patient Perspective: The Case for Transformational One-Time Therapies"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lipoproteins
Discussion Leader: Gissette Reyes-Soffer (Columbia University Medical Center, United States)
9:00 am - 9:20 am
Roop Mallik (Indian Institute of Technology Bombay, India)
"Lipoprotein Secretion: From Physics to Physiology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Shadab Siddiqi (University of Central Florida, United States)
"Regulation of Intracellular VLDL Trafficking and Secretion"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Edward Fisher (NYU School of Medicine, United States)
"Novel Factors Regulating VLDL Triglyceride Production"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Carolin Schneider (UPenn, United States)
"Gain-of-Function Mutations in Microsomal Triglyceride Transfer Protein"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Tabea Moll (Carnegie Institution for Science - Department of Embryology, United States)
"Size is Not Everything: Characterizing Lipoprotein Lifetime in Zebrafish Using a Photoconvertible ApoB Fusion Protein”"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Z. Gordon Jiang (Beth Israel Deaconess Medical Center and Harvard Medical School, United States)
"Altered Lipoprotein Metabolism with Accumulation in Lipoprotein Z Predicts Outcome in Alcoholic Hepatitis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cutting-Edge Technologies for Lipid and Lipoprotein Research
Discussion Leader: Qing Miao (NYU Langone Health, United States)
7:30 pm - 7:50 pm
Chiara Giannarelli (NYU Langone Health, NYU Grossman School of Medicine, United States)
"Single-Cell Strategies to Investigate Lipid Metabolism in Heterogeneous Tissues"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Muredach Reilly (Columbia University, United States)
"Single-Cell Perspectives on Atherosclerosis and Cardiovascular Risk"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Alan Remaley (National Institutes of Health, United States)
"CRISPR-Cas Screen for New Genes Related to LDL Cellular Uptake"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Alex Bashore (Columbia University, United States)
"Single-Cell Transcriptomic Signature of Monocytes in African American Subjects with High Plasma Lipoprotein(a)"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Marianne Teigen (Oslo University Hospital, Norway)
"Classification of Variants of Uncertain Significance in the ABCA1 Gene using a Fluorescence Based Cholesterol Efflux Assay"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure