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Lipoprotein Metabolism (GRS)

Gordon-Merck Research Seminar

June 16 - 17, 2012
Chairs Mistuni Ghosh and Kasuen Mauldin
Waterville Valley
56 Packard's Road
Waterville Valley, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Lipoprotein Metabolism is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

Advances in the field of lipoprotein metabolism have been accelerated by fruitful collaborations among scientists in varied fields of endeavor. Cutting edge scientific tools have provided novel insight into lipoprotein particle composition, heterogeneity and dynamics. Effective and broad dissemination of new scientific knowledge provides a boost to ongoing efforts to translate discoveries into treatments for cardiovascular disease. The 2012 Lipoprotein Metabolism Gordon Research Seminar will provide young investigators in the field of cardiovascular research a stimulating, non-intimidating environment to discuss science with peers and develop future collaborations. The meeting will feature presentations of unpublished research by dynamic young students and post docs. Furthermore, Drs. Sean Davidson and Daisy Sahoo, two young successful faculty members, will serve as Mentors for the Seminar. Both Mentors will be present during research presentations as well as for informal interaction. It is envisioned that GRS participants will also gain insight into the various challenges and rewards of a career in biomedical research.

Related Meeting

This GRC will be held in conjunction with the "Lipoprotein Metabolism" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

SATURDAY
1:00 pm - 5:00 pmArrival and Check-in
3:30 pm - 3:45 pmIntroductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair
3:45 pm - 4:30 pmProteomic and Functional Characterization of HDL Subspecies
3:45 pm - 4:15 pmKeynote Speaker: Scott Gordon (University of Cincinnati)
4:15 pm - 4:30 pmDiscussion
4:30 pm - 6:00 pmPoster Session I
6:00 pmDinner
7:30 pm - 9:30 pmApolipoprotein Structure and Function
Discussion Leaders: Daisy Sahoo (Medical College of Wisconsin) and Scott Gordon (University of Cincinnati)
7:30 pm - 7:50 pmXiaohu Mei (Boston University)
"Crystal Structure of C-terminal Truncated Apolipoprotein A-I Reveals the Assembly of High Density Lipoprotein (HDL) by Dimerization"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmLaura Packer (Boston University)
"The Effect of Familial Hypobetalipoproteinemia Point Mutations on the Structure of the N-terminal Region of Apolipoprotein B"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMatt Mitsche (UT Southwestern)
"Exchangeability of Apolipoprotein Secondary Structure Motifs"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmMingxia Liu (Wake Forest University)
"Hepatic ABCA1 Modulates VLDL TG Secretion by Regulating Apolipoprotein B Trafficking"
9:20 pm - 9:30 pmDiscussion
SUNDAY
7:30 am - 8:30 amBreakfast
9:00 am - 11:00 amStructural Analysis of Lipoprotein Particles
Discussion Leaders: Sean Davidson (University of Cincinnati) and Jens Simonsen (Children's Hospital Oakland Research Institute)
9:00 am - 9:20 amNicholas Lyssenko (Children's Hospital of Philadelphia/University of Pennsylvania)
"The ratio of available cell lipid to lipid-free apolipoprotein AI and other factors that control size heterogeneity of nascent high-density lipoprotein particles"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPhilip Gordts (University of California, San Diego)
"Macrophage Proteoglycans: Decrease in Sulfation Results in Accentuated Atherosclerosis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amNathalie Pamir (University of Washington)
"GM-CSF-dependent dendritic cells limit adipose tissue expansion by restricting adipocyte differentiation"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 amRoy Hernandez (California State University Long Beach)
"Structural Analysis of Human Apolipoprotein E3 by Fluorescence Spectroscopy and Hydrogen/Deuterium Exchange Coupled to Mass Spectrometry"
10:50 am - 11:00 amDiscussion
11:00 am - 12:30 pmPoster Session II
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pmLunch
1:30 pm - 2:30 pmMentorship Component: How to Succeed in Academia
Discussion Leaders: Daisy Sahoo (Medical College of Wisconsin) and Sean Davidson (University of Cincinnati)
2:20 pm - 2:30 pmDiscussion
2:30 pm - 3:00 pmEvaluation Period
Fill out GRS Evaluation Forms
3:00 pmGordon Research Seminar ends. For those attending the associated Gordon Research Conference, please check in at the GRC Office beginning at 4:00 pm.

Contributors

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Conference History Lipoprotein Metabolism
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