Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Academic Careers
Discussion Leaders: Lobna Ali (Academic Medical Center, The Netherlands) and Alexandra Chadwick (University of Pennsylvania, USA)
3:45 pm - 4:15 pm
Daisy Sahoo (Medical College of Wisconsin, USA)
"Managing Uncertainty: Key to Academic Success"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Lipoprotein Structure-Function and Kinetics
Discussion Leaders: Marieli Gonzalez Cotto (National Cancer Institute, NIH, USA) and Kelly Manthei (University of Michigan, USA)
7:30 pm - 7:45 pm
Anna Wolska (National Heart, Lung, and Blood Institute, NIH, USA)
"ApoC-II Mimetic Peptides Decrease Triglycerides by both Activating LPL and Antagonizing Apolipoprotein C-III"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Allison Cooke (University of Cincinnati, USA)
"A Specific Rotamer of Apolipoprotein A-I Enables Lecithincholesterol-Acyl-Transferase (LCAT) Activation by Discoidal HDL"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Rafique Islam (National Institutes of Health, USA)
"Inclusion of A-Methyl Amino Acid Residues in ApoA-I Mimetic Peptides Improves Helicity, Cholesterol Efflux and Resistance to Proteolysis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Aspen Gutgsell (University of North Carolina at Chapel Hill, USA)
"Put a Lid on It: Lipoprotein Lipase Inhibition by Angiopoietin-Like Protein 4 (ANGPTL4)"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Cynthia Traughber (Lerner Research Institute, Cleveland Clinic, USA)
"CRISPR Gene Editing to Elucidate the Roles of HDL Metabolizing Receptors: SR-B1 and ABCA1 in the Regulation of Prostate Cancer Cell Proliferation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Cecilia Vitali (University of Pennsylvania, USA)
"A Naturally-Occurring Variant in the LCAT Gene Displays Increased Esterification Capacity and Represents a Valuable Candidate for AAV-Based Replacement Therapy for LCAT Deficiency"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Regulation of Lipoprotein Metabolism in Disease
Discussion Leaders: Diego Lucero (National Heart, Lung, and Blood Institute, NIH, USA) and Xiao Wang (University of Pennsylvania, USA)
9:00 am - 9:15 am
Jerome Robert (University of British Columbia, Canada)
"High-Density Lipoprotein Promotes Endothelial Health in the Context of Alzheimer's Disease"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Cayla Rodia (University of Connecticut, USA)
"Lipid Provisioning Modifies Treg Metabolism to Protect Against Colitis"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Lars Elmann Larsen (Academic Medical Center, The Netherlands)
"A Murine Model of TMEM199-CDG, a Golgi Trafficking Defect Has Abberant Protein Galactosylation and Fatty Liver"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Paul "Li-Hao" Huang (Washington University in St. Louis School of Medicine, USA)
"Interleukin-17 Driven Trapping of Tissue Lipoproteins Links Immunity to Cardiovascular Risk in Murine Psoriasis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Alfredo Cabrera Socorro (Janssen Pharmaceutica, Johnson & Johnson, Belgium)
"ApoE in Alzheimer's Disease"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Kelly Mitok (University of Wisconsin-Madison, USA)
"Mutation in Sortilin Identified in an Amish Population Results in Hyperinsulinemia and Hypercholesterolemia in Humans and Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers in Academia and Industry
Discussion Leaders: Swapnil Shewale (University of Pennsylvania, USA) and Allison Andraski (Harvard T.H. Chan School of Public Health, USA)
1:30 pm - 2:30 pm
Panel Discussion
Careers in Academia and Industry
Alison Kohan (University of Connecticut, USA)
Norman C.W. Wong (University of Calgary, Canada)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
