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Lung Development, Injury and Repair

Gordon Research Conference

Building and Rebuilding the Lung

August 14 - 19, 2011
Chair Lynn M. Schnapp
Vice Chair Barry R. Stripp
Salve Regina University
100 Ochre Point Avenue
Newport, Rhode Island, United States
 Venue and Travel Information

Conference Description

Lung diseases present a huge global health burden with over 600 million people worldwide affected by diseases such as COPD and pulmonary fibrosis. Furthermore, acute lung injury is a common response to infection with many emerging pathogens. Despite the huge health burden, there are relatively few, if any therapeutic agents that improve survival for these diseases. Because injury and repair often utilize similar pathways, understanding the common biological principles will facilitate developing innovative treatments for lung disease. This conference will emphasize mechanisms in lung development, injury and repair and focus on new advances in these fields such as microRNA, systems biology, and bioengineering. By bringing together a diverse and outstanding group of investigators together to present the most up-to-date advances in these related fields, we hope to encourage creative and multidisciplinary approaches that will ultimately facilitate development of innovative and effective therapies.

Conference Program

SUNDAY
2:00 pm - 9:00 pmArrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pmDinner
7:30 pm - 7:45 pmWelcome / Introductory Comments by GRC Site Staff
7:45 pm - 9:30 pmEVOLUTIONARY VIEW OF THE LUNG
Discussion Leader: Lynn Schnapp (University of Washington)
7:45 pm - 8:20 pm David Warburton (Children’s Hospital, USC
"Lung progenitor functions in integrated development and rebuilding of the lung"
8:20 pm - 8:35 pm Discussion
8:35 pm - 9:15 pm Ross Metzger (USCF)
"Branching Subroutines in Lung Development and Evolution"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBUILDING BLOCKS OF THE LUNG
Discussion Leader: Anne Pearl (University of Cincinnati)
9:00 am - 9:30 am David Ornitz (Washington University)
"Growth factors in Lung Development"
9:30 am - 9:45 am Discussion
9:45 am - 9:55 am Gianni Carraro (University of Giessen)
"Critical role of miR-142 on the regulation of FGF signaling in the lung"
9:55 am - 10:05 am Discussion
10:05 am - 10:40 am Group Photo / Coffee Break
10:40 am - 11:00 am Nan Tang (UCSF)
"Control of mitotic spindle angle by RAS-regulated ERK1/2 signaling determines airway shape"
11:00 am - 11:10 am Discussion
11:10 am - 11:30 pm Adam Giangreco (Imperial College)
"Beta catenin regulates normal and preinvasive airway epithelial growth and lineage choice via modulation of stem cell adhesiveness"
11:30 pm - 11:40 pm Discussion
11:45 am - 12:15 pm Akiko Hata (Tufts University)
"MicroRNA regulation of pulmonary vascular smooth muscle proliferation and differentiation"
12:15 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Lung Development
6:00 pmDinner
7:30 pm - 9:30 pmBALANCING ACT: REPAIR PATHWAYS GONE AWRY
Discussion Leader: Tom Mariani (University of Rochester)
7:30 pm - 8:00 pm Martin Privalsky (University of California, Davis)
"Transcriptional co-repressors in development and COPD"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Paul Noble (Duke University)
"Role of Hyaluronan in Lung injury and repair"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Enid Neptune (Johns Hopkins University)
"Molecular mechanisms of genetic emphysema"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDESTROYING THE LUNG
Discussion Leader: William Parks (University of Washington)
9:00 am - 9:30 am Dean Sheppard (UCSF)
"New Roles of Integrins in Lung Injury and Repair"
9:30 am - 9:45 am Discussion
9:45 am - 9:55 amMegan Ballinger (University of Michigan)
"The Role Of An Important Negative Regulator Of Toll Like Receptor Signaling, IRAK-M, In Mediating The Generation Of Antioxidants During Hyperoxic Lung Injury"
9:55 am - 10:05 amDiscussion
10:05 am - 10:35 Coffee Break
10:35 am - 11:10 am Tyler Jacks (MIT)
"Injury and Lung Cancer"
11:10 am - 11:30 am Discussion
11:30 am - 12:10 pm Irina Petrache (Indiana University)
"Contribution of endothelial apoptosis in lung pathology/emphysema"
12:10 pm - 12:30 pm Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Lung Injury
6:00 pmDinner
7:30 pm - 9:30 pmSCARRED FOR LIFE? FIBROSIS AND MATRIX REMODELING
Discussion Leader: Rachel Chambers (University College London)
7:30 pm - 8:00 pm Christine Garcia (University of Texas, Southwestern Medical Center)
"Telomerase mutations and Idiopathic Pulmonary Fibrosis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Daniel J. Tschumperlin (Harvard School of Public Health)
"Mechanical influences on lung fibroblast behavior"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Andreas Günther (Justus-Liebig University, Germany)
"Chronic epithelial injury as trigger event in lung fibrosis"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSEEING IS BELIEVING: IMAGING THE LUNG
Discussion Leader: Sharon Rounds (Brown University)
9:00 am - 9:30 am Matthias Ochs (Hannover Medical School)
"If seeing is believing, is counting knowing? Morphometry of the lung"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 amNazgol Seyednejad (UBC)
"The Remodeling of the Small Conducting Airways in COPD"
9:50 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 11:00 am Matthew (Max) Krummel (UCSF)
"In vivo imaging of lymphocyte function in the lung"
11:00 am - 11:15 am Discussion
11:15 am - 11:45 am Phil Low (Purdue University)
"Ligand-targeted therapeutic and imaging agents for inflammatory diseases"
11:45 am - 12:00 pm Discussion
12:00 pm - 12:20 pmLi-Chin Yao (UCSF)
"Dynamics of button-like junctions in the endothelium of airway lymphatics in development and inflammation"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session: Lung Repair
6:00 pmDinner
7:30 pm - 9:30 pmTHE ROAD TO RECOVERY: PATHWAYS IN LUNG REPAIR
Discussion Leader: Barry Stripp (Duke University)
7:30 pm - 8:00 pm Oliver Eickelberg (Helmholtz Zentrum München)
"New Pathways in Lung repair"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Richard Cummings (Emory University)
"Role of Glycans in lung injury: hitting the sweet spot"
8:40 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Hal Chapman (University of California, San Francisco)
"Signaling pathways in epithelial-mesenchymal transition"
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pmINTERVENTION: REBUILDING THE LUNG
Discussion Leader: Melanie Konigshoff (Helmholtz Zentrum München)
9:00 am - 9:30 am Barry Shea (Massachusetts General Hospital)
"Leaky lungs: linking acute lung injury and fibrosis"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 amPoornima Mahavadi (Geissen)
"Lysosomal stress and apoptosis of alveolar epithelial cells in a murine model of amiodarone induced pulmonary fibrosis"
9:50 am - 10:00 amDiscussion
10:00 am Coffee Break
10:30 am - 11:00 am Erica Herzog (Yale University)
"Tissue-engineered Lungs for in vivo implantation"
11:00 am - 11:15 am Discussion
11:15 am - 11:30 pm Peter Chen (University of Washington)
"Syndecan-1 Regulation of Airway Re-epithelialization"
11:30 am - 11:40 am Discussion
11:40 am - 11:55 pm Xinguo Jiang (Stanford)
"Adenovirus-Mediated Hypoxia Inducible Factor (HIF)-1Alpha Gene Transfer Promotes Repair Of Airway Allograft Microvasculature And Attenuates Chronic Rejection"
11:55 am - 12:05 am Discussion
12:05 am - 12:20 pm Sekhar Reddy (University of Illinois, Chicago)
"Targeted Deletion Of Jun/Ap-1 In Alveolar Epithelial Cells Causes Progressive Emphysema And Worsens Cigarette Smoke-Induced Lung Inflammation"
12:20 am - 12:30 am Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time/Soccer Match!
4:00 pm - 6:00 pmPoster Session: Interventions
6:00 pmDinner
7:30 pm - 9:30 pmINTERVENTION: FIXING THE LUNG
Discussion Leader: Bethany Moore (University of Michigan)
7:30 pm - 8:10 pm Renata Pasqualini and Wadih Arap (MD Anderson)
"New strategies for targeting the lung vasculature"
8:10 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Sheila Violette (Stromedix)
"Going from bench to bedside in the real world: avb6 antibody and fibrosis"
9:10 pm - 9:30 pm Discussion
FRIDAY
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Contributors

Conference Links

Conference History
Additional Fee Info

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