Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Evolutionary Plasticity of the Lung in Response to Environmental Changes: Lessons We Can Learn for Pulmonary Medicine
Discussion Leader: Susan Guttentag (Vanderbilt University, USA)
7:40 pm - 8:10 pm
Kenneth Storey (Carleton University , Canada)
"Evolutionary Adaptions to Stress: Lessons from Animals in Extreme Environments"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
John Torday (University of California, Los Angeles, USA)
"Evolution, the Logic of Biology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Kent Pinkerton (University of California, Davis, USA)
"Susceptibility of the Developing Lung to Environmental Injury"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells: Which Ones at Which Stage of Life and in Response to Disease?
Discussion Leader: Brigid Hogan (Duke University, USA)
9:00 am - 9:30 am
Edward Morrisey (University of Pennsylvania, USA)
"Generation and Regeneration of the Lung"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Daniel Lafkas (Genentech Inc., USA)
"Dissecting the Role of Notch Signaling in the Adult Airway"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Carla Bender Kim (Childrens Hospital Boston, USA)
"Stem
Cell Approaches to Understanding Differentiation, Disease and Therapy
in the Lung"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
Purushothama Rao Tata (Duke University School of Medicine, USA)
"Cellular Heterogeneity and Plasticity
in Lung Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Hal Chapman (University of California, San Francisco, USA)
"Differentiation and Selection of Adult Alveolar Progenitor Cells"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Johannes Schittny (Institute of Anatomy, University of Bern, Switzerland)
"Development of the Acinar Airspaces Visualized by High Resolution 3D-Lung Imaging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Susan Guttentag (Vanderbilt University, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Layering Regulatory Networks
of Differentiation into a Blueprint
Discussion Leader: Thomas Mariani (University of Rochester Medical Center, USA)
7:30 pm - 7:55 pm
Tushar Desai (Stanford School of Medicine, USA)
"Multiplexed In Situ Hybridization for
Molecular Profiling of Single Cells in Intact Tissues"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Jichao Chen (University of Texas M. D. Anderson Cancer Center, USA)
"A Hierarchical Gene Regulatory Network Controlling SOX9 Epithelial Progenitors"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Yan Xu (Cincinnati Children's Hospital Medical Center, USA)
"Transcriptional Programming of Respiratory Epithelia at Single Cell Level"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
David Frank (University of Pennsylvania / Children's Hospital of Philadelphia, USA)
"Early Lung Progenitor Cell Commitment Redefines Alveolar Epithelial Ontogeny"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Communication Systems
Discussion Leader: Saverio Bellusci (Justus-Liebig-University Giessen, Germany)
9:00 am - 9:30 am
Wellington Cardoso (Columbia University Medical Center, New York, USA)
"Control of the Progenitor Cell Pool
and Lineage Specification in the Airway Epithelium"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Elie El Agha (JLU Giessen, Germany)
"Mesenchymal Plasticity Governs the
Progression and Resolution of Lung Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 11:00 am
Emma Rawlins (University of Cambridge, United Kingdom)
"Integrating Signaling Inputs to
Maintain Lung Epithelial Progenitor Fate in the Developing Human Lung"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
Roxana Wasnick (Justus Liebig University Giessen, Germany)
"The Role of
Notch Signaling Pathway in the Aetiology and Pathogenesis of Idiopathic
Pulmonary Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
Parviz Minoo (University of Southern California, USA)
"Biology of Alveolar Formation: The Role of Secondary Crest Myofibroblasts"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Joo-Hyeon Lee (University of Cambridge, United Kingdom)
"Anatomically and Functionally Distinct Mesenchymal Lineages in Lung Homeostasis and Regeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Communication Systems
Discussion Leader: Boris Hinz (University of Toronto, Canada)
7:30 pm - 7:55 pm
Victor Thannickal (University of Alabama, Birmingham, USA)
"Cell-Matrix
Interactions that Determine Progression of Lung Fibrosis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Gisli Jenkins (University of Nottingham, United Kingdom)
"G
Protein Regulation of Pulmonary Mechanobiology and Fibrosis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Daniel Tschumperlin (Mayo Clinic, USA)
"Mechanical
Activation of Fibroblasts: Experimental Challenges and Translational
Opportunities"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Alexandra Noel (Louisiana State University, USA)
"Increased Extracellular Matrix Remodeling Promotes Urethane-Induced Lung Carcinomas and Metastases in Mice Exposed In Utero to Second-Hand Smoke"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Origin and Consequences of Cellular Stress
Discussion Leader: Timothy Blackwell (Vanderbilt University, USA)
9:00 am - 9:20 am
Ana Mora (University of Pittsburgh, USA)
"Mitochondrial
Dysfunction in Lung Fibrosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Poornima Mahavadi (Justus-Liebig University Giessen, Germany)
"Defective
Autophagy and Lysosomal Stress in Lung Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Silke Meiners (Comprehensive Pneumology Center Munich, Germany)
"Dysfunction
of the Proteasome System in Lung Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
Jonathan Kropski (Vanderbilt University Medical Center, USA)
"Genetic Variation in RTEL1 in Pulmonary Fibrosis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
Jeanine D'Armiento (Columbia University Medical Center, New York, USA)
"Lung Injury Response in COPD/Emphysema"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
William Janssen (National Jewish Health, USA)
"Metabolic Reprogramming of Recruited Macrophages Promotes Repair of the Injured Alveolus"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulating Inflammation in the Lung
Discussion Leader: Irina Petrache (National Jewish Health, USA)
7:30 pm - 8:00 pm
Andrew Loudon (University of Manchester, United Kingdom)
"Pulmonary Circadian Clocks and Inflammation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
Lawrence Prince (University of California, San Diego / Rady Children's Hospital, USA)
"The Inflammasome and Developmental
Regulation of Lung Inflammation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
Claudia Jakubzick (National Jewish Medical Research Center, USA)
"Macrophage
Diversity in the Lungs of Mice and Humans"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Rania Dagher (MedImmune, USA)
"IL-33 Regulates Monocyte Differentiation and Impacts Epithelial Repair via ILC2 Activation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Rewards of Systems Biology in an Omics Age
Discussion Leader: Naftali Kaminski (Yale University, USA)
9:00 am - 9:30 am
Ziv Bar-Joseph (Carnegie Mellon University, USA)
"Reconstructing Regulatory Networks
from Time Series Single Cell
Lung Development Data"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
Smita Krishnaswamy (Yale School of Medicine, USA)
"Diffusion-Based Representations for Revealing Progressions, Multi-Scale Clusters and Gene Interactions in Noisy Single Cell Data"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
Koji Sakamoto (Nagoya University Gradulate School of Medicine, Japan, Japan)
"LincRNA Regulation of Fibroblast Transcriptional Networks in Pulmonary Fibrosis"
11:00 am - 11:20 am
Discussion
11:20 am - 11:50 am
Max Seibold (National Jewish Health, USA)
"Single Cell Transcriptomics of the Airway Epithelium in Asthma and Health"
11:50 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Jennifer Sucre (Vanderbilt University, USA)
"Hyperoxia Exposure of Developing Lung Epithelium Promotes Activated Wnt Signaling in Underlying Mesenchyme"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Smaller, the Better: Reductionist Models of Lung Biology
Discussion Leader: Barry Stripp (Cedars Sinai Medical Center, USA)
7:30 pm - 7:55 pm
Kambez Benam (University of Colorado School of Medicine, USA)
"Lung
Pathophysiology in Three Dimensions: Introducing Human ‘Small Airway-on-a-Chip’"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Andrew Thorley (Imperial College London, United Kingdom)
"Alveolar
Epithelial-Macrophage Crosstalk in the Innate Immune Response to Infection"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
Finn Hawkins (Boston University Medical Center, USA)
"Using
iPSCs to Model Human Lung Development and Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Evan Eichler (University of Washington / Howard Hughes Medical Institute, USA)
"Emergence of Human-Specific Genes and CNV Disease Susceptibility"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure