Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Evolutionary Plasticity of the Lung in Response to Environmental Changes: Lessons We Can Learn for Pulmonary Medicine
7:40 pm - 8:10 pm
"Evolutionary Adaptions to Stress: Lessons from Animals in Extreme Environments"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Evolution, the Logic of Biology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Susceptibility of the Developing Lung to Environmental Injury"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Stem Cells: Which Ones at Which Stage of Life and in Response to Disease?
9:00 am - 9:30 am
"Generation and Regeneration of the Lung"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Dissecting the Role of Notch Signaling in the Adult Airway"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
"Stem
Cell Approaches to Understanding Differentiation, Disease and Therapy
in the Lung"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
"Cellular Heterogeneity and Plasticity
in Lung Regeneration"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Differentiation and Selection of Adult Alveolar Progenitor Cells"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Development of the Acinar Airspaces Visualized by High Resolution 3D-Lung Imaging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Layering Regulatory Networks
of Differentiation into a Blueprint
7:30 pm - 7:55 pm
"Multiplexed In Situ Hybridization for
Molecular Profiling of Single Cells in Intact Tissues"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"A Hierarchical Gene Regulatory Network Controlling SOX9 Epithelial Progenitors"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Transcriptional Programming of Respiratory Epithelia at Single Cell Level"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Early Lung Progenitor Cell Commitment Redefines Alveolar Epithelial Ontogeny"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Communication Systems
9:00 am - 9:30 am
"Control of the Progenitor Cell Pool
and Lineage Specification in the Airway Epithelium"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Mesenchymal Plasticity Governs the
Progression and Resolution of Lung Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Group Photo / Coffee Break
10:30 am - 11:00 am
"Integrating Signaling Inputs to
Maintain Lung Epithelial Progenitor Fate in the Developing Human Lung"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"The Role of
Notch Signaling Pathway in the Aetiology and Pathogenesis of Idiopathic
Pulmonary Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 12:00 pm
"Biology of Alveolar Formation: The Role of Secondary Crest Myofibroblasts"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Anatomically and Functionally Distinct Mesenchymal Lineages in Lung Homeostasis and Regeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cell-Matrix Communication Systems
7:30 pm - 7:55 pm
"Cell-Matrix
Interactions that Determine Progression of Lung Fibrosis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"G
Protein Regulation of Pulmonary Mechanobiology and Fibrosis"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Mechanical
Activation of Fibroblasts: Experimental Challenges and Translational
Opportunities"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Increased Extracellular Matrix Remodeling Promotes Urethane-Induced Lung Carcinomas and Metastases in Mice Exposed In Utero to Second-Hand Smoke"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Origin and Consequences of Cellular Stress
9:00 am - 9:20 am
"Mitochondrial
Dysfunction in Lung Fibrosis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Defective
Autophagy and Lysosomal Stress in Lung Fibrosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Dysfunction
of the Proteasome System in Lung Diseases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Genetic Variation in RTEL1 in Pulmonary Fibrosis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Lung Injury Response in COPD/Emphysema"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Metabolic Reprogramming of Recruited Macrophages Promotes Repair of the Injured Alveolus"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Regulating Inflammation in the Lung
7:30 pm - 8:00 pm
"Pulmonary Circadian Clocks and Inflammation"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"The Inflammasome and Developmental
Regulation of Lung Inflammation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Macrophage
Diversity in the Lungs of Mice and Humans"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"IL-33 Regulates Monocyte Differentiation and Impacts Epithelial Repair via ILC2 Activation"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Rewards of Systems Biology in an Omics Age
9:00 am - 9:30 am
"Reconstructing Regulatory Networks
from Time Series Single Cell
Lung Development Data"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Diffusion-Based Representations for Revealing Progressions, Multi-Scale Clusters and Gene Interactions in Noisy Single Cell Data"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 11:00 am
"LincRNA Regulation of Fibroblast Transcriptional Networks in Pulmonary Fibrosis"
11:00 am - 11:20 am
Discussion
11:20 am - 11:50 am
"Single Cell Transcriptomics of the Airway Epithelium in Asthma and Health"
11:50 am - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"Hyperoxia Exposure of Developing Lung Epithelium Promotes Activated Wnt Signaling in Underlying Mesenchyme"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Smaller, the Better: Reductionist Models of Lung Biology
7:30 pm - 7:55 pm
"Lung
Pathophysiology in Three Dimensions: Introducing Human ‘Small Airway-on-a-Chip’"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Alveolar
Epithelial-Macrophage Crosstalk in the Innate Immune Response to Infection"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:35 pm
"Using
iPSCs to Model Human Lung Development and Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Emergence of Human-Specific Genes and CNV Disease Susceptibility"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure