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Lung Development, Injury and Repair

Gordon Research Conference

Harnessing Lung Complexity Towards Improved Health Across the Lifespan

August 4 - 9, 2019

Chairs

and

Vice Chairs

and

Bates College

2 Andrews Road

Lewiston, Maine, United States

Venue and Travel Information

Conference Description

Optimal lung health from embryo through adulthood requires the complex interaction of pulmonary airspaces, interstitial and vasculature, beginning with organ development and culminating in programmed senescence. Technological advances have fostered a growing appreciation for the impact of cellular plasticity and the importance of cellular niche both during development and in response to both injury and repair. In addition to expanding the role of reactivation of developmental pathways lung repair, recent discoveries have demonstrated unique aging programs that will provide novel treatment strategies for chronic lung disease.

The 5th Gordon Research Conference on Lung Development, Injury and Repair in August of 2019 seeks to attract cutting edge science to drive forward the field of lung development, injury, and repair toward the goal of facilitating novel therapeutic approaches to maximize lung health across the lifespan. This conference will strive to highlight new concepts behind the interactions of cells and matrices that define specialized niches within the lung, and how niches change across the lifespan to influence lung development, injury, and repair.

Related Meeting

This GRC will be held in conjunction with the "Lung Development, Injury and Repair" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Harnessing Biological Complexity in the Lung Discussion Leader:
7:40 pm - 7:45 pm	Opening Remarks
7:45 pm - 8:30 pm	"Reserve Airway Stem Cell Compartment with Enhanced Regenerative Capacity"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Human vs Mouse: Species Differences in Lung Development"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Sex as a Biological Variable in Lung Injury and Repair"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Early Lung Development: From Bench to Bedside Discussion Leader:
9:00 am - 9:25 am	"Molecular Basis of Tracheal Mesenchyme Patterning"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Genetic Mechanisms of Congenital Diaphragmatic Hernia"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Epigenomic Analysis of Sox9+ Lung Epithelial Progenitor Cell Specification Defines New Transcriptional Regulatory Networks in Lung Development"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Non-Coding RNA Control of Lung Alveologenesis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Indicators and Treatable Traits in Neonatal Chronic Lung Disease"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Yap Nucleocytoplasmic Shuttling Is Crucial for Regulation of Region-Specific Developmental Programs in the Lung Epithelium"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Pulmonary Vasculature: Influential Conduits of Development, Injury and Repair Discussion Leader:
7:30 pm - 7:55 pm	"Lung Lymphatics Play Important Roles in Resolution of Injury"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"The Role of Vascular Permeability in Pulmonary Fibrosis"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Transcriptional Mechanisms of Lung Endothelial Regeneration and Endothelial Heterogeneity"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	"B1 Integrin Regulates Alveolar Homeostasis Through Alveolar Epithelial Cell Inflammatory Signaling"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Identification of Transcriptional Regulators Critical for Re-Programming of Normal Lung Endothelial Cells into Fibrosis-Promoting Endothelial Cells in IPF"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Terminal Bronchiole as a Specialized Transitional Lung Niche Discussion Leader:
9:00 am - 9:25 am	"Tissue Injury and Repair in Human Lungs"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Traversing the Wall: Signaling Across the Basement Membrane in Airway Regeneration"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Maternal Oxysterol Plays a Critical Role in Fetal Lung Alveolarization"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Human Distal Airways in Lung Injury Following Smoke Exposure and Allergic Inflammation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Early Postnatal Establishment of the Alveolar Epithelial Niche"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"An Ex Vivo Microfluidic Neonatal Lung Model to Visualize and Quantify the Dynamics of Alveolar Morphogenesis"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Transcriptional Networks Regulating Multiciliogenesis in the Mammalian Airway"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Small Populations of Lung Cells with Big Impact Discussion Leader:
7:30 pm - 7:55 pm	"Consider the Lung as a Sensory Organ"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Influenza-Induced Tuft Cells: Friend, Foe or Frenemy?"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"The Role of Susceptible Airway Epithelial Cells in COPD"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"High Resolution Evaluation of Human Airway Cell Diversity Towards Understanding the Cellular Composition and Function of the Distal Human Airways"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:25 pm	"Interrogating Transcriptional Networks in Alveolar Epithelial Progenitor Cells"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Epithelial Adaptation Shaping Lung Niches Discussion Leader:
9:00 am - 9:25 am	"Epithelial Cell Unjamming in Airway Injury, Repair and Regeneration"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"What an Ultrathin Cell Can Do: Structural and Signaling Roles of the Lung Alveolar Type 1 Cell"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Microvesicle Expression of Growth Hormone Receptor from Mesenchymal Cells Supports the Lung Epithelial Stem Cell Niche and Abrogates Pulmonary Fibrosis in Mice"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Vascular Niche Regulation of Lung Regeneration and Fibrosis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Exosomes in Lung Development and Injury"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"GATA3 Regulation of Cldn1 in Basal Cells of the Human Airway Epithelium"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Single-Cell RNA Sequencing Identifies Conserved Inflammatory Airspace Macrophage Subsets in Mice and Humans"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	The Role of the Extracellular Matrix in Establishing and Maintaining Lung Regions Discussion Leader:
7:30 pm - 7:55 pm	"The Triple Helix of Collagens: An Ancient Structure Enabling Tissue Adaptation"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	"The Matrix Drives Aberrant Repair Responses in Chronic Lung Diseases"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Supramolecular Complex of Collagen IV and Proteoglycans Within Developing Basement Membrane"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	"Multi-Omics Analysis of Extracellular Niche Composition and Dynamic Changes During Lung Regeneration and Fibrosis Development"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Hyaluronan Synthase 3-Expressing Macrophages Drive Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Combined Pulmonary Fibrosis and Emphysema (CPFE)"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Regional and Temporal Mesenchymal Cell Identity Discussion Leader:
9:00 am - 9:25 am	"Location, Location, Location! Unique Stromal Neighborhoods Influence Differentiation and Maintenance of the Kidney"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"PDGF-A: Is There a Role in the Adult Lung"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Tcf21 Signaling in Lipofibroblast and Airway Development"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Mesenchymal Hedgehog Signaling: Expected and Unexpected Effects During Postnatal Lung Growth"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Relevant Immune Mechanisms for Estrogen-Mediated Pulmonary Fibrosis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Hyperoxia Injury of Saccular Stage Lung Results in Increased Mesenchymal Expression of Wnt5a that Is Driven by Upregulated Nf-kB Signaling"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Myofibroblast Contraction Is Essential for Generating and Regenerating the Gas-Exchange Surface"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Aging and Senescence in Shaping the Lung Across the Lifespan Discussion Leaders: and
7:30 pm - 8:00 pm	"The Lung Microenvironment Drives Immune Responses to Pathogens and Particles During Aging"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:15 pm	"Glutaminase 1 and NAD-Dependent Deacetylase SIRT7 Regulate TGF-β Mediated Pulmonary Fibrosis"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:30 pm	"Circadian Rhythms in the Lung: A Life Course Perspective"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	"Senescent Cells as a Driver of Aging and Their Mitigation"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Y.S. Prakash, MD, PhD and Christina Pabelick, MD

Mayo Clinic - Department of Physiology and Biomedical Engineering

Conference Links

Conference History Lung Development, Injury and Repair (GRS)

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