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Lung Development, Injury and Repair

Gordon Research Conference

Harnessing Lung Complexity Towards Improved Health Across the Lifespan

August 4 - 9, 2019

Chairs Susan Guttentag and Irina Petrache

Vice Chairs Anne-Karina Perl and Daniel J. Tschumperlin

Bates College

2 Andrews Road

Lewiston, Maine, United States

Venue and Travel Information

Conference Description

Optimal lung health from embryo through adulthood requires the complex interaction of pulmonary airspaces, interstitial and vasculature, beginning with organ development and culminating in programmed senescence. Technological advances have fostered a growing appreciation for the impact of cellular plasticity and the importance of cellular niche both during development and in response to both injury and repair. In addition to expanding the role of reactivation of developmental pathways lung repair, recent discoveries have demonstrated unique aging programs that will provide novel treatment strategies for chronic lung disease.

The 5th Gordon Research Conference on Lung Development, Injury and Repair in August of 2019 seeks to attract cutting edge science to drive forward the field of lung development, injury, and repair toward the goal of facilitating novel therapeutic approaches to maximize lung health across the lifespan. This conference will strive to highlight new concepts behind the interactions of cells and matrices that define specialized niches within the lung, and how niches change across the lifespan to influence lung development, injury, and repair.

Related Meeting

This GRC will be held in conjunction with the "Lung Development, Injury and Repair" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Harnessing Biological Complexity in the Lung Discussion Leader: Thomas Mariani (University of Rochester, USA)
7:40 pm - 7:45 pm	Opening Remarks
7:45 pm - 8:30 pm	John Engelhardt (University of Iowa, USA) "Reserve Airway Stem Cell Compartment with Enhanced Regenerative Capacity"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	Denise Al Alam (Children's Hospital Los Angeles, USA) "Human vs Mouse: Species Differences in Lung Development"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	Krithika Lingappan (Baylor College of Medicine, USA) "Sex as a Biological Variable in Lung Injury and Repair"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Early Lung Development: From Bench to Bedside Discussion Leader: Edward Morrisey (University of Pennsylvania, USA)
9:00 am - 9:25 am	Debora Sinner (Cincinnati Children's Hospital Medical Center, USA) "Molecular Basis of Tracheal Mesenchyme Patterning"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	David McCulley (University of Wisconsin-Madison, USA) "Genetic Mechanisms of Congenital Diaphragmatic Hernia"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Daniel Swarr (Cincinnati Children's Hospital Medical Center, USA) "Epigenomic Analysis of Sox9+ Lung Epithelial Progenitor Cell Specification Defines New Transcriptional Regulatory Networks in Lung Development"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	Rory Morty (Max Planck Institute for Heart and Lung Research, Germany) "Non-Coding RNA Control of Lung Alveologenesis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	Anne Hilgendorff (Comprehensive Pneumology Center, Ludwig Maximilian University of Munich / Helmholtz Zentrum München, Germany) "Indicators and Treatable Traits in Neonatal Chronic Lung Disease"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Benjamin van Soldt (Columbia University Medical Center, USA) "Yap Nucleocytoplasmic Shuttling Is Crucial for Regulation of Region-Specific Developmental Programs in the Lung Epithelium"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	David Frank (Children's Hospital of Philadelphia / University of Pennsylvania, USA) "Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizer: Anne-Karina Perl (Cincinnati Children's Hospital Medical Center, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Pulmonary Vasculature: Influential Conduits of Development, Injury and Repair Discussion Leader: Susan Majka (National Jewish Health, USA)
7:30 pm - 7:55 pm	Souheil El-Chemaly (Brigham and Women's Hospital, USA) "Lung Lymphatics Play Important Roles in Resolution of Injury"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Rachel Knipe (Massachusetts General Hospital, USA) "The Role of Vascular Permeability in Pulmonary Fibrosis"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	Asrar Malik (University of Illinois at Chicago, USA) "Transcriptional Mechanisms of Lung Endothelial Regeneration and Endothelial Heterogeneity"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	Erin Plosa (Vanderbilt University, USA) "B1 Integrin Regulates Alveolar Homeostasis Through Alveolar Epithelial Cell Inflammatory Signaling"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Tatiana Kalin (Cincinnati Children's Hospital Medical Center, USA) "Identification of Transcriptional Regulators Critical for Re-Programming of Normal Lung Endothelial Cells into Fibrosis-Promoting Endothelial Cells in IPF"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Terminal Bronchiole as a Specialized Transitional Lung Niche Discussion Leader: Patty Lee (Duke University School of Medicine, USA)
9:00 am - 9:25 am	Dragos Vasilescu (Centre for Heart Lung Innovation, University of British Columbia, Canada) "Tissue Injury and Repair in Human Lungs"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Tien Peng (University of California, San Francisco, USA) "Traversing the Wall: Signaling Across the Basement Membrane in Airway Regeneration"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Mitsuyoshi Suzuki (Stem Cell Center, Lund University, Sweden) "Maternal Oxysterol Plays a Critical Role in Fetal Lung Alveolarization"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	Hong Chu (National Jewish Health, USA) "Human Distal Airways in Lung Injury Following Smoke Exposure and Allergic Inflammation"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	Parviz Minoo (University of Southern California, USA) "Early Postnatal Establishment of the Alveolar Epithelial Niche"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Jason Gleghorn (University of Delaware, USA) "An Ex Vivo Microfluidic Neonatal Lung Model to Visualize and Quantify the Dynamics of Alveolar Morphogenesis"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Semil Choksi (University of California, San Francisco, USA) "Transcriptional Networks Regulating Multiciliogenesis in the Mammalian Airway"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Small Populations of Lung Cells with Big Impact Discussion Leader: Purushothama Rao Tata (Duke University School of Medicine, USA)
7:30 pm - 7:55 pm	Xin Sun (University of California, San Diego, USA) "Consider the Lung as a Sensory Organ"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Andrew Vaughan (University of Pennsylvania, USA) "Influenza-Induced Tuft Cells: Friend, Foe or Frenemy?"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	Yohannes Tesfaigzi (Lovelace Respiratory Research Institute, USA) "The Role of Susceptible Airway Epithelial Cells in COPD"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Maria Basil (Perelman School of Medicine, University of Pennsylvania, USA) "High Resolution Evaluation of Human Airway Cell Diversity Towards Understanding the Cellular Composition and Function of the Distal Human Airways"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:25 pm	William Zacharias (Cincinnati Children's Hospital, USA) "Interrogating Transcriptional Networks in Alveolar Epithelial Progenitor Cells"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Epithelial Adaptation Shaping Lung Niches Discussion Leader: Jeanine D'Armiento (Columbia University Medical Center, USA)
9:00 am - 9:25 am	Jin-Ah Park (Harvard University, USA) "Epithelial Cell Unjamming in Airway Injury, Repair and Regeneration"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Jichao Chen (University of Texas MD Anderson Cancer Center, USA) "What an Ultrathin Cell Can Do: Structural and Signaling Roles of the Lung Alveolar Type 1 Cell"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Ting Xie (Cedars-Sinai Medical Center, USA) "Microvesicle Expression of Growth Hormone Receptor from Mesenchymal Cells Supports the Lung Epithelial Stem Cell Niche and Abrogates Pulmonary Fibrosis in Mice"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	Bi-Sen Ding (Icahn School of Medicine at Mount Sinai, USA) "Vascular Niche Regulation of Lung Regeneration and Fibrosis"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	Namasivayam Ambalavanan (University of Alabama at Birmingham, USA) "Exosomes in Lung Development and Injury"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Robin Lochbaum (Institute of General Physiology, Ulm University, Germany) "GATA3 Regulation of Cldn1 in Basal Cells of the Human Airway Epithelium"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Kara Mould (National Jewish Health, USA) "Single-Cell RNA Sequencing Identifies Conserved Inflammatory Airspace Macrophage Subsets in Mice and Humans"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	The Role of the Extracellular Matrix in Establishing and Maintaining Lung Regions Discussion Leader: Daniel Tschumperlin (Mayo Clinic, USA)
7:30 pm - 7:55 pm	Billy Hudson (Vanderbilt University, USA) "The Triple Helix of Collagens: An Ancient Structure Enabling Tissue Adaptation"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:25 pm	Janette Burgess (University Medical Center Groningen, The Netherlands) "The Matrix Drives Aberrant Repair Responses in Chronic Lung Diseases"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	Elena Pokidysheva (Vanderbilt University Medical Center, USA) "Supramolecular Complex of Collagen IV and Proteoglycans Within Developing Basement Membrane"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	Herbert Schiller (Helmholtz Zentrum München, Germany) "Multi-Omics Analysis of Extracellular Niche Composition and Dynamic Changes During Lung Regeneration and Fibrosis Development"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Harry Karmouty Quintana (University of Texas Health Science Center at Houston, USA) "Hyaluronan Synthase 3-Expressing Macrophages Drive Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Combined Pulmonary Fibrosis and Emphysema (CPFE)"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Regional and Temporal Mesenchymal Cell Identity Discussion Leader: Anne-Karina Perl (Cincinnati Children's Hospital Medical Center, USA)
9:00 am - 9:25 am	Thomas Carroll (University of Texas Southwestern Medical Center, USA) "Location, Location, Location! Unique Stromal Neighborhoods Influence Differentiation and Maintenance of the Kidney"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	Johanna Andrae (Uppsala University, Sweden) "PDGF-A: Is There a Role in the Adult Lung"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	Juwon Park (University of Hawaii at Manoa, USA) "Tcf21 Signaling in Lipofibroblast and Airway Development"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	Matthias Kugler (New York University School of Medicine, USA) "Mesenchymal Hedgehog Signaling: Expected and Unexpected Effects During Postnatal Lung Growth"
11:20 am - 11:30 am	Discussion
11:30 am - 11:55 am	Wonder Drake (Vanderbilt University, USA) "Relevant Immune Mechanisms for Estrogen-Mediated Pulmonary Fibrosis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Jennifer Sucre (Vanderbilt University, USA) "Hyperoxia Injury of Saccular Stage Lung Results in Increased Mesenchymal Expression of Wnt5a that Is Driven by Upregulated Nf-kB Signaling"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Rongbo Li (University of California, San Diego, USA) "Myofibroblast Contraction Is Essential for Generating and Regenerating the Gas-Exchange Surface"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Aging and Senescence in Shaping the Lung Across the Lifespan Discussion Leaders: Elena Lopez-Rodriguez (Charité - Universitätsmedizin Berlin, Germany) and Jennifer Sucre (Vanderbilt University, USA)
7:30 pm - 8:00 pm	G.R. Scott Budinger (Northwestern University, USA) "The Lung Microenvironment Drives Immune Responses to Pathogens and Particles During Aging"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:15 pm	Malay Choudhury (Mayo Clinic, USA) "Glutaminase 1 and NAD-Dependent Deacetylase SIRT7 Regulate TGF-β Mediated Pulmonary Fibrosis"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:30 pm	Shaon Sengupta (University of Pennsylvania, USA) "Circadian Rhythms in the Lung: A Life Course Perspective"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	Laura Niedernhofer (Institute on the Biology of Aging and Metabolism, University of Minnesota, USA) "Senescent Cells as a Driver of Aging and Their Mitigation"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Y.S. Prakash, MD, PhD and Christina Pabelick, MD

Mayo Clinic - Department of Physiology and Biomedical Engineering

Conference Links

Conference History Lung Development, Injury and Repair (GRS)

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