Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Orchestrating Cellular Differentiation to Shape the Lung
Discussion Leaders: Rory Morty (University Hospital Heidelberg, Germany) and Chimwemwe Mwase (Harvard University, USA)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
Dean Sheppard (University of California, San Francisco, USA)
"Lung Fibroblast Heterogeneity in Health and Disease"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
Ying Tian (Temple University, USA)
"Regulation of Lung Epithelial Repair by Mitochondrial Calcium Uptake"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Soumyaroop Bhattacharya (University of Rochester, USA)
"Transcriptomic Profiling of Lung Tissue from Active and Recovered SARS-CoV-2 Infections "
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Formation and Remodeling of Lung Vasculature in Health and Disease
Discussion Leaders: Claude Jourdan Le Saux (University of California, San Francisco, USA) and Rachel Knipe (Massachusetts General Hospital, USA)
9:00 am - 9:30 am
Grazyna Kwapiszewska (Medical University of Graz / Ludwig Boltzmann Institute for Lung Vascular Research, Austria)
"United in Diversity: Cellular Changes in Pulmonary Vascular Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Naftali Kaminski (Yale University, USA)
"The Endothelial Cell Atlas of the Lung"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Zhiyu Dai (University of Arizona, USA)
"Fatty Acid-Binding Proteins Control Endothelial Cells Glycolysis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:35 am
Susan Majka (National Jewish Health, USA)
"Lung Mesenchymal Vascular Progenitors Modulate Adaptive Angiogenesis and Tissue Remodeling"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Patricia Brazee (Massachusetts General Hospital, USA)
"The Role of Endothelial S1PR1 Signaling in Respiratory Viral Induced ARDS and Fibroproliferation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Nunzia Caporarello (Mayo Clinic, USA)
"Dysfunctional ERG Signaling Drives Pulmonary Vascular Aging and Progressive Fibrosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hasina Outtz Reed (Weill Cornell Medicine, USA)
"Cigarette Smoke Causes Lung Lymphatic Dysfunction and Thrombosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Lynn Schnapp (University of Wisconsin School of Medicine and Public Health, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diversity of Fibroblasts and Their Roles in Health and Disease
Discussion Leaders: Deneen Wellik (University of Wisconsin-Madison, USA) and Yael Aschner (University of Colorado, USA)
7:30 pm - 8:00 pm
Michelle Tallquist (University of Hawaii, USA)
"Functional Heterogeneity of Fibroblasts in Alveologenesis and Asthma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Ping Hu (University of Virginia, USA)
"GPI-Anchored Cell-Surface Proteins Distinguish Fibroblast Subsets and Their Integrin Activity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Elizabeth Redente (National Jewish Health, USA)
"Reducing Fibroblast Persistence in Pulmonary Fibrosis as a Mechanism of Resolution"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
David Boyd (University of California, Santa Cruz, USA)
"Severe Influenza Virus Infection Induces Persistent Fibroblast Activation Associated with Prolonged Respiratory Distress"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunology in Lung Injury and Repair
Discussion Leaders: Alexandra McCubbrey (National Jewish Health, USA) and Ravi Misra (University of Rochester Medical Center, USA)
9:00 am - 9:40 am
Yuval Rinkevich (Helmholtz Zentrum München, Germany)
"Fibroblastic Cell Lineages in Scarring and Regeneration"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
Jie Sun (Mayo Clinic, USA)
"CD8 T Cells and Lung Sequelae Post Viral Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
Thomas Mariani (University of Rochester, USA)
"Mast Cells and Chronic Lung Disease of Prematurity"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
Benjamin Singer (Feinberg School of Medicine, Northwestern University, USA)
"Epigenetic Control of the Pro-Lung Recovery Functions of Regulatory T Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Megan Ballinger (The Ohio State University, USA)
"Macrophage-Fibroblast Interactions Contribute to Collagen Expression and Lung Remodeling During Pulmonary Fibrosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targets, Tools and Strategies in Lung Repair
Discussion Leaders: Parviz Minoo (University of Southern California, USA) and Harry Karmouty Quintana (University of Texas Health Science Center at Houston, USA)
7:30 pm - 7:55 pm
Purushothama Rao Tata (Duke University School of Medicine, USA)
"Multi-Faceted Lung Stem Cell Dynamics at Single Cell Resolution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Rachel Zemans (University of Michigan, USA)
"The Epithelial Transitional Cell State in Physiologic and Pathologic Alveolar Regeneration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Mingxia Gu (Cincinnati Children's Hospital Medical Center, USA)
"Recreating Pulmonary Vasculature from iPSCs for Disease Modeling and Drug Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Darrell Kotton (Boston University, USA)
"Reconstitution of the Injured Lung Epithelium via Transplantation of iPSC Derived Lung Progenitors"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lung Injury and Chronic Sequelae
Discussion Leaders: Jeffrey Horowitz (The Ohio State University Wexner Medical Center, USA) and Denise Al Alam (Lundquist Institute for Biomedical Innovation, USA)
9:00 am - 9:40 am
Richard Jenkins (Imperial College London, United Kingdom)
"Alveolar Injury and the Development of Post COVID Fibrosis"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
Laura Crotty Alexander (University of California, San Diego / VA San Diego Healthcare System, USA)
"E-Cigarette and Vaping Associated Lung Inflammation and Injury: Mechanisms and Outcomes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
Andrew Haak (Mayo Clinic, USA)
"Dopamine Synthesis and D1 Receptor Agonism Are Essential for Resolution of Experimental Lung Fibrosis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
Joo-Hyeon Lee (University of Cambridge, United Kingdom)
"The Journey of Alveolar Regeneration Directed by Niches"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Corrine Kliment (University of Pittsburgh School of Medicine, USA)
"Loss of Mitochondrial Adenine Nucleotide Translocase 2 (Ant2) in Alveolar Epithelial Cells Worsens Emphysema Through Cellular Senescence in a Mouse Model of COPD"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Antony Rodriguez (Baylor College of Medicine, USA)
"The Microrna Let-7 Orchestrates Lung Inflammation and COPD or IPF-Like Disease in an Intrinsic Manner in T Cells and Epithelial Alveolar Type II Cells (AT2) in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kent Willis (The University of Alabama at Birmingham, USA)
"The Gut-Lung Axis Influences the Development of Bronchopulonary Dysplasia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Epithelial Injury and Functional Regeneration
Discussion Leaders: Tien Peng (University of California, San Francisco, USA) and Jason Gokey (Vanderbilt University Medical Center, USA)
7:30 pm - 8:10 pm
Edward Morrisey (University of Pennsylvania, USA)
"Lung Regeneration: A Tale of Mice and Men"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
Enid Neptune (Johns Hopkins University School of Medicine, USA)
"Redirecting Growth Factor Signaling for Lung Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Allison Greaney (Yale University, USA)
"Building Epithelial Barrier in Whole-Lung Tissue Engineering"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Claudia Loebel (University of Michigan, USA)
"Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lung Development and Its Lessons for Repair
Discussion Leaders: Wellington Cardoso (Columbia University Medical Center, USA) and Satish Madala (Cincinnati Children's Hospital Medical Center, USA)
9:00 am - 9:45 am
Emma Rawlins (University of Cambridge, United Kingdom)
"Building the Human Lung: Lessons from Organoids"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
Soula Danopoulos (Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, USA)
"Transcriptional Characterization Suggests Accelerated Epithelial Differentiation in Trisomy 21 Lungs"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
Hal Chapman (University of California, San Francisco, USA)
"Metaplastic Alveolar Basal Cells in IPF Arise from AT2 Cells Through Aberrant Mesenchyme Signaling"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
Yujuan Su (University of California, San Diego, USA)
"Manipulating Neural Circuits as a Strategy to Control Lung Functio"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
Stijn De Langhe (Mayo Clinic in Rochester, Minnesota, USA)
"Lung Stem Cells and Their Niches"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Roy Morello (University of Arkansas for Medical Sciences, USA)
"Intrinsic Lung and Respiratory System Changes in Mouse Models of Osteogenesis Imperfecta"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Bridging Discovery to Therapy
Discussion Leaders: Xin Sun (University of California, San Diego, USA) and Semil Choksi (University of California, San Francisco, USA)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
Konstantinos Alysandratos (Center for Regenerative Medicine, Boston University School of Medicine, USA)
"Patient-Specific iPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:20 pm
David Ornitz (Washington University in St. Louis, USA)
"FGF Signaling in Hypoxia-Induced Pulmonary Hypertension"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Vladimir Kalinichenko (Cincinnati Children's Hospital Medical Center, USA)
"Developing Novel Therapeutic Approaches for Treatment of Alveolar Capillary Dysplasia and Bronchopulmonary Dysplasia"
9:10 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure