Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Orchestrating Cellular Differentiation to Shape the Lung
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
"Lung Fibroblast Heterogeneity in Health and Disease"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Regulation of Lung Epithelial Repair by Mitochondrial Calcium Uptake"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Transcriptomic Profiling of Lung Tissue from Active and Recovered SARS-CoV-2 Infections "
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Formation and Remodeling of Lung Vasculature in Health and Disease
9:00 am - 9:30 am
"United in Diversity: Cellular Changes in Pulmonary Vascular Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Endothelial Cell Atlas of the Lung"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Fatty Acid-Binding Proteins Control Endothelial Cells Glycolysis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:35 am
"Lung Mesenchymal Vascular Progenitors Modulate Adaptive Angiogenesis and Tissue Remodeling"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Role of Endothelial S1PR1 Signaling in Respiratory Viral Induced ARDS and Fibroproliferation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Dysfunctional ERG Signaling Drives Pulmonary Vascular Aging and Progressive Fibrosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cigarette Smoke Causes Lung Lymphatic Dysfunction and Thrombosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diversity of Fibroblasts and Their Roles in Health and Disease
7:30 pm - 8:00 pm
"Functional Heterogeneity of Fibroblasts in Alveologenesis and Asthma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"GPI-Anchored Cell-Surface Proteins Distinguish Fibroblast Subsets and Their Integrin Activity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Reducing Fibroblast Persistence in Pulmonary Fibrosis as a Mechanism of Resolution"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Severe Influenza Virus Infection Induces Persistent Fibroblast Activation Associated with Prolonged Respiratory Distress"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunology in Lung Injury and Repair
9:00 am - 9:40 am
"Fibroblastic Cell Lineages in Scarring and Regeneration"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"CD8 T Cells and Lung Sequelae Post Viral Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Mast Cells and Chronic Lung Disease of Prematurity"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Epigenetic Control of the Pro-Lung Recovery Functions of Regulatory T Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Macrophage-Fibroblast Interactions Contribute to Collagen Expression and Lung Remodeling During Pulmonary Fibrosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targets, Tools and Strategies in Lung Repair
7:30 pm - 7:55 pm
"Multi-Faceted Lung Stem Cell Dynamics at Single Cell Resolution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"The Epithelial Transitional Cell State in Physiologic and Pathologic Alveolar Regeneration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Recreating Pulmonary Vasculature from iPSCs for Disease Modeling and Drug Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Reconstitution of the Injured Lung Epithelium via Transplantation of iPSC Derived Lung Progenitors"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lung Injury and Chronic Sequelae
9:00 am - 9:40 am
"Alveolar Injury and the Development of Post COVID Fibrosis"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
"E-Cigarette and Vaping Associated Lung Inflammation and Injury: Mechanisms and Outcomes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Dopamine Synthesis and D1 Receptor Agonism Are Essential for Resolution of Experimental Lung Fibrosis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"The Journey of Alveolar Regeneration Directed by Niches"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Loss of Mitochondrial Adenine Nucleotide Translocase 2 (Ant2) in Alveolar Epithelial Cells Worsens Emphysema Through Cellular Senescence in a Mouse Model of COPD"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Microrna Let-7 Orchestrates Lung Inflammation and COPD or IPF-Like Disease in an Intrinsic Manner in T Cells and Epithelial Alveolar Type II Cells (AT2) in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Gut-Lung Axis Influences the Development of Bronchopulonary Dysplasia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Epithelial Injury and Functional Regeneration
7:30 pm - 8:10 pm
"Lung Regeneration: A Tale of Mice and Men"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Redirecting Growth Factor Signaling for Lung Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Building Epithelial Barrier in Whole-Lung Tissue Engineering"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lung Development and Its Lessons for Repair
9:00 am - 9:45 am
"Building the Human Lung: Lessons from Organoids"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Transcriptional Characterization Suggests Accelerated Epithelial Differentiation in Trisomy 21 Lungs"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Metaplastic Alveolar Basal Cells in IPF Arise from AT2 Cells Through Aberrant Mesenchyme Signaling"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Manipulating Neural Circuits as a Strategy to Control Lung Functio"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Lung Stem Cells and Their Niches"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Intrinsic Lung and Respiratory System Changes in Mouse Models of Osteogenesis Imperfecta"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Bridging Discovery to Therapy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
"Patient-Specific iPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:20 pm
"FGF Signaling in Hypoxia-Induced Pulmonary Hypertension"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
"Developing Novel Therapeutic Approaches for Treatment of Alveolar Capillary Dysplasia and Bronchopulmonary Dysplasia"
9:10 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure