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Lung Development, Injury and Repair

Gordon Research Conference

Post-COVID Return to Respiratory Health

August 13 - 18, 2023

Chairs Rory E. Morty and Xin Sun

Vice Chairs Darrell Kotton and Susan M. Majka

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Lung Development, Injury and Repair GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Proper lung function is paramount to human health, a fact underscored by the COVID pandemic. Aside from respiratory viral infection, there are many other causes for lung diseases, including genetic predisposition, pollutant, allergen, bacterial infection and prematurity. It is well established that the adult lung re-activates developmental programs to repair the lung in response to injury. However, in pathological conditions, dysplastic remodeling sets the foundation for chronic lung diseases. Research is being conducted to comprehensively define the molecular progression of lung development on multiple scales, to draw parallels between lung development and regeneration, and to uncover distinctions between normal repair and dysplastic remodeling. It is exciting time in the study of lung biology. The latest discoveries in the field of Lung Development, Injury and Repair will be presented, debated, and translated into more effective clinical practice at the 2023 Gordon Research Conference.

Related Meeting

This GRC will be held in conjunction with the "Lung Development, Injury and Repair" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Post-COVID Opportunities to Broaden Lung Biology Discussion Leaders: Darrell Kotton (Boston University, United States) and Justinn Barr (University of California San Diego, United States)
7:40 pm - 8:00 pm	James Kiley (NIH, United States) "Progress and Opportunities in Lung Development, Injury and Repair: A NHLBI Perspective"
8:00 pm - 8:15 pm	Discussion
8:15 pm - 8:55 pm	Zea Borok (University of California San Diego, United States) "Breaking Down Barriers to Lung Repair and Regeneration: Unlocking the Plasticity of Alveolar Epithelial Cells"
8:55 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Post-COVID Priorities in Lung Injury Repair Discussion Leaders: Lynn Schnapp (University of Wisconsin School of Medicine and Public Health, United States) and Krithika Lingappan (Children's Hospital of Philadelphia, United States)
9:00 am - 9:20 am	Edward Morrisey (University of Pennsylvania, United States) "Lung Stem Cells in Injury Repair"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Finn Hawkins (Boston University, United States) "Human iPSCs to Study the Molecular Programs of Lung Injury and Repair"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	Enid Neptune (Johns Hopkins University School of Medicine, United States) "Mechanistic Themes from the Marfan Lung"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Group Photo / Coffee Break
10:50 am - 11:10 am	Jianwen Que (Columbia University, United States) "Signaling Factors Promoting Pathological Fibroblast Differentiation in Injury Models"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Leah Reznikov (University of Florida, United States) "BDNF Regulation of Airway Mucins"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Harry Karmouty Quintana (University of Texas Health Science Center at Houston, United States) "Non-Resolvable COVID-19: A Tale of Transitional Stem Cell Recruitment and Extracellular Matrix Deposition"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Purushothama Rao Tata (Duke University School of Medicine, United States) "Emphysema or Fibrosis: Two Sides of the Same Coin"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Denise Al Alam (Lundquist Institute for Biomedical Innovation, United States) and Nabora Reyes de Barboza (University of California San Francisco, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Tipping the Balance from Dysplastic to Regenerative Repair Discussion Leaders: Stijn De Langhe (Mayo Clinic in Rochester, Minnesota, United States) and Yuru Liu (University of Illinois at Chicago, United States)
7:30 pm - 7:50 pm	Peter Chen (Cedars-Sinai Medical Center, United States) "Fungal Dysbiosis in Post-Influenza MRSA Infection"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	Alexandra Noel (Louisiana State University, United States) "Role of IL-10 in transcriptomic alterations in the developing mouse lung caused by in utero electronic-cigarette aerosol exposures"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	Anny Zhou (Brigham and Women's Hospital, United States) "Function of Genetic Determinants for COPD and IPF in Lung Epithelial Cells"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	Arun Prakash (University of California, San Francisco, United States) "Role of Diet and Gut Microbiome in Regulating Lung Injury Responses"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Timothy Blackwell (Vanderbilt University Medical Center, United States) "Epithelial Determinants of Functional Alveolar Repair"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	An Ageless Lung Discussion Leaders: Wellington Cardoso (Columbia Center for Human Development, Columbia University Medical Center, United States) and David Frank (Children's Hospital of Philadelphia / University of Pennsylvania, United States)
9:00 am - 9:20 am	Jichao Chen (University of Texas MD Anderson Cancer Center, United States) "Transcriptional Control and Evolution of Lung Alveolar Cell Fates"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Le Xu (University of California San Diego, United States) "Context-Dependent Requirements for Mitochondria Function in Lung"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	Anne-Karina Perl (Cincinnati Children's Hospital Medical Center, United States) "Age of the Fibroblast: Transition or Existing on a Spectrum?"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Jennifer Sucre (Vanderbilt University, United States) "A 4-Dimensional Fabric: Considerations of Space and Time in Lung Development and Disease"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Elizabeth Taglauer (Boston University Chobanian & Avedisian School of Medicine, United States) "Defining the Pulmonary Developmental Niche: Identifying Placental Mechanisms of Developmental Lung Injury"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Mereena George Ushakumary (Pacific Northwest National Laboratory, United States) "Proteomic Analysis of Human Bronchopulmonary Dysplasia Lung"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	John Engelhardt (University of Iowa, United States) "Submucosal Gland and Rare Cell Progenitors in the Ferret Proximal Airway"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Insights from Single Cell Resolution Discussion Leaders: Gloria Pryhuber (University of Rochester, United States) and Maya Kumar (Stanford University, United States)
7:30 pm - 7:50 pm	Kerstin Meyer (Wellcome Sanger Institute, United Kingdom) "COVID-19: Insights from In Vitro Infection and a Human SARS-CoV-2 Challenge Study"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	Patricia Brazee (Massachusetts General Hospital, United States) "Endothelial S1PR1 Suppresses Endothelin 1 Signaling and Attenuates Fibrosis After Influenza Virus Infection"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	Oindrila Paul (Children's Hospital of Philadelphia, United States) "Effect of Environmental Lighting on Circadian Gating on Lung Injury from Influenza"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	William Zacharias (Cincinnati Children's Hospital, United States) "Genetic and Epigenetic Regulators of Alveolar Progenitor Function in Regeneration"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Jonathan Kropski (Vanderbilt University Medical Center, United States) "Alveolar Responses to Recurrent Injury"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Fibroblasts Discussion Leaders: Rachel Knipe (Massachusetts General Hospital, United States) and Erin Plosa (Vanderbilt University Medical Center, United States)
9:00 am - 9:20 am	Daniel Tschumperlin (Mayo Clinic, United States) "Fibroblast Roles in Fibrosis and Repair"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Andrea Alber (Boston University, United States) "Directed Differentiation of Pluripotent Stem Cells into Functional Lung-Specific Mesenchyme"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	Tien Peng (University of California, San Francisco, United States) "Fibroblast Tuning of the Inflammatory Niche"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Elie El Agha (Justus-Liebig University Giessen, Germany) "The Mesenchymal Niche During Airway Epithelial Regeneration"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Emma Mason (National Jewish Health, United States) "Wnt Signaling in Mesenchymal Vascular Progenitor (MVPC) Drives Adaptive Angiogenesis During Fibrosis and Regulates Pulmonary Tissue Repair"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Matt Thomas (Boehringer Ingelheim, Germany) "Biomarkers of Pulmonary Fibrosis – Their Utility in Drug Discovery"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	James Hagood (University of North Carolina at Chapel Hill, United States) "Unusual Interstitial Pneumonia: How Should We Think About Fibrosis in Children?"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Lung as a Sensory Organ Discussion Leaders: Jie Sun (University of Virginia, United States) and Maria Basil (UPenn, United States)
7:30 pm - 7:50 pm	Nora Barrett (Brigham and Women's Hospital, United States) "Linking Tuft Cells to Airway Damage Sensing and Repair"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	Christin Kuo (Stanford University, United States) "Cellular and Molecular Diversity of Peripheral Glia in the Lung and their Development"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	Sara Prescott (Massachusetts Institute of Technology, United States) "Sensory Mechanisms of the Mammalian Airways"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	Pengfei Sui (Introduction Shanghai Institute of Biochemistry and Cell Biology, China) "Infection Induced Inflammatory Signal Triggers Lung Dysplastic Remodeling"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Andrew Vaughan (University of Pennsylvania, United States) "Multiple Modes of Lung Repair in Severe Viral Pneumonia"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Circulating Cells in the Lung-Body Dialogue Discussion Leaders: Laura Crotty Alexander (University of California, San Diego / VA San Diego Healthcare System, United States) and Yang Zhou (Brown University, United States)
9:00 am - 9:20 am	G.R. Scott Budinger (Northwestern University, United States) "Molecular Pathology in Patients with SARS-CoV-2 Pneumonia Reveals Disease Pathobiology"
9:20 am - 9:30 am	Discussion
9:30 am - 9:45 am	Eniko Sajti (University of California San Diego, United States) "TREM2 Regulates the Lung Innate Immune Response and the Severity of Hyperoxia Induced Lung Injury"
9:45 am - 9:50 am	Discussion
9:50 am - 10:10 am	William Janssen (National Jewish Health, United States) "Macrophage Heterogeneity During Repair of Acute Lung Injury"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	Nicholas Lukacs (University of Michigan, United States) "Early Life Pulmonary Viral Infection Alters Long Term Function and Structure"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Alison May (Icahn School of Medicine at Mount Sinai, United States) "Tissue-Resident Macrophage Regulation of Airway Submucosal Gland Development"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	Fabienne Gally (National Jewish Health, United States) "Fatty Acid Binding Protein 5 (FABP5) Promotes the Resolution of Inflammation in a Mouse Model of Chronic Obstructive Pulmonary Disease (COPD) Exacerbations"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	Mark Looney (University of California, San Francisco, United States) "Profiling and Mapping of Hematopoietic Stem Cell Reservoirs in the Human Lung"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: The Rules and Exceptions of Pulmonary Vessels Discussion Leaders: Susan Majka (University of Colorado-National Jewish Health, United States) and Jaymin Kathiriya (Icahn School of Medicine, Mount Sinai, United States)
7:30 pm - 7:50 pm	Grazyna Kwapiszewska (Ludwig Boltzmann Institute for Lung Vascular Research, Austria) "Pulmonary Vascular Remodeling a Breakdown in Communication?"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	David McCulley (University of California San Diego, United States) "SIN3A Directs Lung and Pulmonary Vascular Development by Controlling the Balance of Histone Acetylation"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	Larissa Shimoda (Johns Hopkins School of Medicine, United States) "Beyond Water: A Surprising Role for Aquaporin 1 in Regulating Lung Vascular Cell Function"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Jeffrey Whitsett (CCHMC, United States) "Rearranging the Genome for the First Breath at Birth"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Cedars-Sinai Medical Center

Kalpaj and Mona Parekh

John Engelhardt

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL168969. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

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