Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Unraveling the Mysteries of Lung Biology
Discussion Leader: Franck Kamga Gninzeko (Virginia Commonwealth University, USA)
3:45 pm - 4:20 pm
Xin Sun (University of California, San Diego, USA)
"Why Lung? What this Beautiful Organ Has Taught Us from Gas Exchange to Interoception"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Basic Principles of Lung Development and Function
Discussion Leader: Terren Niethamer (University of Pennsylvania, USA)
7:30 pm - 7:45 pm
Elizabeth Corteselli (University of Vermont, USA)
"Increases in Glutathione Dependent Protein Oxidation Impair Airway Basal Cell Differentiation"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Ahmad Nabhan (Genentech, USA)
"Sculpting Regeneration with Cell-Specific Wnt Agonists"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Xin Wang (Brigham and Women's Hospital / Harvard Medical School, USA)
"Basal Cell Adhesion Molecule Marks a Nasal Airway Epithelial Stem Cell Population that Is Increased in Patients with Chronic Rhinosinusitis with Nasal Polyps"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Claire Burgess (Boston University, USA)
"Generation of Human Alveolar Epithelial Type I Cells from Pluripotent Stem Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Jason Gokey (Vanderbilt University Medical Center, USA)
"YAP Regulates Alveolar Epithelial Cell Differentiation and AGER via NFIB/KLF5/NKX2-1"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Matthew Riccetti (Cincinnati Children's Hospital Medical Center, USA)
"Maladaptive Functional Changes in Alveolar Fibroblasts due to Perinatal Hyperoxia Impair Epithelial Differentiation"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Identifying Causes of Lung Disease and Therapeutic Strategies
Discussion Leader: Jaymin Kathiriya (University of California, San Francisco, USA)
9:00 am - 9:15 am
Daniel Abebayehu (University of Virginia, USA)
"Myeloid-Derived IL-1 Signaling Induces Unique Immuno-Fibroblast Subpopulations Critical for Pulmonary Fibrosis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Terren Niethamer (University of Pennsylvania, USA)
"Pulmonary Endothelial Cell Expression of ATF3 Plays a Critical Role in Lung Regeneration"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Franck Kamga Gninzeko (Virginia Commonwealth University, USA)
"Mechanical Ventilator Induced Senescence and DNA Damage in an Aging Model of Acute Lung Injury"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Grace Bingham (University of Virginia, USA)
"Comparative Analysis of Fibrosis and Immune Signatures in Patients with Long-Haul COVID and Idiopathic Pulmonary Fibrosis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Dawn Bravo (Stanford School of Medicine, USA)
"Pre-Clinical Development of an Autologous Gene Corrected Stem Cell Therapy to Treat Cystic Fibrosis in the Upper Airways"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Sriram Vaidyanathan (Stanford University, USA)
"Fibrinogen Based Scaffolds Support the Transplantation of Gene Edited Upper Airway Basal Stem Cells in Immunocompromised Mice"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Exploring Careers in Lung Biology
Discussion Leader: Anne-Karina Perl (Cincinnati Children's Hospital Medical Center, USA)
1:30 pm - 2:30 pm
Panel Discussion
Careers in Lung Biology
Laura Crotty Alexander (University of California, San Diego / VA San Diego Healthcare System, USA)
Rory Morty (University Hospital Heidelberg, Germany)
Daniel Tschumperlin (Mayo Clinic, USA)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes