Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Building Lymphatics |
| Discussion Leader: Anne Eichmann (Yale School of Medicine, USA) |
7:40 pm - 7:45 pm | Opening Remarks |
7:45 pm - 8:05 pm | Benjamin Hogan (University of Queensland, Australia) "New Mechanisms of Lymphatic Vascular Development from Zebrafish" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Mark Kahn (University of Pennsylvania, USA) "Molecular Regulation of Lymphatic Development" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Guillermo Oliver (Northwestern University, USA) "The Specification of Lymphatic Fate, a Key Step in Lymphatic Development" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Stefan Schulte-Merker (Westfälische Wilhelms-Universität Münster, Germany) "Novel Genes Essential for Lymphangiogenesis in Fish and Mice" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | The Interstitial Microenvironment and Recent Focus on Interstitial Flow in the Brain |
| Discussion Leader: Melody Swartz (University of Chicago, USA) |
9:00 am - 9:20 am | Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland) "Are Dural Lymphatics Involved in Neuropathology?" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Jonathan Kipnis (University of Virginia, USA) "Lymphatics in the Central Nervous System" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Samia Bachmann (ETH Zurich, Switzerland) "In Vivo Regulation of Lymphatic Vessel Function by the Autonomous Nervous System" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Masataka Majima (Kitasato University School of Medicine, Japan) "Roles of RAMP-1 Signalling as a Neuronal Cue of Lymphangiogenesis" |
10:25 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jens Titze (Vanderbilt University, USA) "Sodium and the Microenvironment Inside and Outside the Lymphatics" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Helge Wiig (University of Bergen, Norway) "On the New Role of the Interstitium and Lymphatics in the Development of Hypertension" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Cathryn Kolka (Cedars-Sinai Medical Center, USA) "The Lymphatic System as a Tool for the Study of Insulin Trafficking in Interstitial Fluid of Skeletal Muscle" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Hector Peinado (Spanish National Cancer Research Centre (CNIO), Spain) "Exosomes Shed by Tumor Cells into the Interstitium Transit to LNs and Reprogram the Microenvironment" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
3:00 pm - 4:00 pm | Power Hour |
| The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring. |
| Organizer: Laura Santambrogio (Albert Einstein College of Medicine, USA) |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Collecting Lymphatic Vessels and Mechanics |
| Discussion Leader: David Zawieja (Texas A&M University, USA) |
7:30 pm - 7:50 pm | Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland) "Biomechanical and Transcriptional Regulation of Lymphatic Vessel Function" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Michael Davis (University of Missouri School of Medicine, USA) "KATP Channels Are an Important Component of Lymphatic Dysfunction in Cantu Syndrome" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Brandon Dixon (Georgia Institute of Technology, USA) "Lymphatic Remodeling as a Driving Force in Collecting Vessel Pump Failure in Lymphedema" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Niklas Telinius (Aarhus University Hospital, Denmark) "Voltage-Gated Sodium Channels Contribute to Action Potentials and Spontaneous Contractility in Isolated Human Lymphatic Vessels" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Joshua Scallan (University of South Florida, USA) "Regulation of Collecting Lymphatic Vessel Permeability by Dendritic Cells Expressing CCR7 and IRF4" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Lymph Node and Lymphatics in Immunity |
| Discussion Leader: Nancy Ruddle (Yale School of Public Health, USA) |
9:00 am - 9:20 am | Jason Cyster (University of California, San Francisco, USA) "Lymph Node Lymphatic Sinuses and Immunity" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Reinhold Forster (Hannover Medical School, Germany) "Migration of Lymphocytes into and Within Lymph Nodes" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | James Moore (Imperial College London, United Kingdom) "Analysis of Fluid Flow Through Lymph Nodes" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Lijun Xia (Oklahoma Medical Research Foundation, USA) "Signals Governing Lymph Node Integrity" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Shannon Turley (Genentech, USA) "Podoplanin Function in Lymphoid Stroma" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Melody Swartz (University of Chicago, USA) "Lymphatics in Immune Modulation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Beth Tamburini (University of Colorado Anschutz Medical Campus, USA) "Contraction of the Hypertrophic Lymph Node and Death of Lymphatic Endothelial Cells as a Process for Antigen Exchange" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Genetics and Lymphedema |
| Discussion Leader: Stanley Rockson (Stanford University School of Medicine, USA) |
7:30 pm - 7:50 pm | Miikka Vikkula (de Duve Institute, Université Catholique de Louvain, Belgium) "Genes Implicated in the VEGFR3 Signaling Pathway Explain 30% of Primary Lymphedema" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Sahar Mansour (St. George's, University of London, United Kingdom) "Two New Genetic Disorders Presenting with Lymphatic-Related Hydrops Fetalis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Babak Mehrara (Memorial Sloan-Kettering Cancer Center, USA) "Cellular Mechanisms of Lymphatic Regeneration and Dysfunction in Lymphedema" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Marco Borri (CR-UK Cancer Imaging Centre / Royal Marsden NHS Foundation Trust / Institute of Cancer Research, United Kingdom) "Magnetic Resonance for Improved Understanding of Collecting Lymphatic Vessels Morphology and Tissue Composition in Breast Cancer Related Lymphedema" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Barbara Garmy-Susini (Inserm, France) "Beneficial Effect of Estrogen on Lymphatic System Is Inhibited by Hormone Therapy to Promote Lymphedema" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Signals that Regulate the Lymphatic Vasculature in Development, Health, and Cancer / Advances in Imaging |
| Discussion Leader: Gou Young Koh (Korea Advanced Institute of Science and Technology, South Korea) |
9:00 am - 9:20 am | Karina Yaniv (Weizmann Institute of Science, Israel) "Building Lymphatic Vessels in Vertebrates: Insights from Zebrafish" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Anne Eichmann (Yale School of Medicine, USA) "Neuropilin Regulation of Lymphatics" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Steve Watson (Birmingham University, United Kingdom) "CLEC-2 and Podoplanin Crosstalk Between Platelets and Lymphatics" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:40 am | Natasha Harvey (Centre for Cancer Biology, University of South Australia, Australia) "Control of Lymphatic Valve Morphogenesis by Gata2" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:05 am | Coffee Break |
11:05 am - 11:25 am | Michael Detmar (ETH Zurich, Switzerland) "Important Roles of Lymphatic Vessels in the Control of Inflammation and the Promotion of Distant Cancer Metastasis" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:55 am | Mihaela Skobe (Icahn School of Medicine at Mount Sinai, USA) "Lymphatic Metastasis and Metastatic Efficiency" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Eelco Meijer (Massachusetts General Hospital, USA) "In Vivo Label-Free Measurement of Lymph Flow Velocity and Volumetric Flow Rates Using Doppler Optical Coherence Tomography" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Rene Haegerling (Max Planck Institute for Molecular Biomedicine, Germany) "A Novel Imaging Approach for the 3D Visualization of Blood and Lymphatic Vasculature in Healthy and Lymphoedema Affected Humans" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Lymphangioleiomyomatosis (LAM) and mTOR in Lymphatic Biology |
| Discussion Leader: Mark Kahn (University of Pennsylvania, USA) |
7:30 pm - 7:50 pm | Frank McCormack (University of Cincinnati, USA) "Lymphatic Manifestations of Lymphangioleiomyomatosis" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kuniaki Seyama (Juntendo University, Japan) "Isolation and Characterization of LAM Cells" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Lisa Henske (Harvard Medical School, USA) "Role of Cellular Metabolism and Autophagy in Lymphangioleiomyomatosis (LAM): From Pathogenesis to Targeted Therapy" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Donald McDonald (University of California, San Francisco, USA) "Rapamycin Reversal of Lymphangiectasia in a Mouse Model" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lymphatics in the Intestine, Mesentery, and Visceral Fat |
| Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, USA) |
9:00 am - 9:20 am | Taija Makinen (Uppsala University, Sweden) "Organ-Specific Origins of the Lymphatic Vasculature" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Natasza Kurpios (Cornell University, USA) "Dual Origin of Intestinal Lymphatic Vasculature Is Established via Integration of Pitx2 and Cxcl12/Cxcr4 Chemotaxis" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Gou Young Koh (Korea Advanced Institute of Science and Technology, South Korea) "Intestinal Lymphatic Lacteals" |
10:20 am - 10:30 am | Discussion |
10:30 am - 10:40 am | Jeremiah Bernier-Latmani (University of Lausanne, Switzerland) "Mechanisms of Notch Signaling in Adult Intestinal Lacteals" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Jean-Frederic Colombel (Mount Sinai School of Medicine, USA) "Clinical and Experimental Observations Implicating a Role for Lymphatic Vessels in Crohn's Disease" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Sonia Rehal (University of Calgary, Canada) "Intestinal Lymphatic Pathology and Lymph Transport in Mouse Crohn's Disease-Like Ileitis" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Reema Davis (University of North Carolina at Chapel Hill, USA) "Lymphatic Vessels in Intestinal Inflammation and Repair" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Joseph Rutkowski (Texas A&M Health Science Center, USA) "Adipose Tissue VEGF-D Overexpression Induces Local Lymphangiogenesis and Altered Lipid Handling" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Jerome Breslin (University of South Florida, USA) "Remodeling of Mesenteric Collecting Vessels in Juvenile, Obese Zucker Rats" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lymphatics in the Cardiovascular System |
| Discussion Leader: Natasha Harvey (Centre for Cancer Biology, University of South Australia, Australia) |
7:30 pm - 7:50 pm | Paul Riley (University of Oxford, United Kingdom) "Heterogeneity of Lymphatics in the Heart and Its Implications" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Kathleen Caron (University of North Carolina, USA) "Adrenomedullin in Cardiac and Lymphatic Development" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Michael Dellinger (University of Texas Southwestern Medical Center, USA) "Overexpression of VEGF-C in Bone Induces a Gorham-Stout Disease-Like Phenotype" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Seppo Yla-Herttuala (University of Eastern Finland, Finland) "Lymphatics and Atherosclerosis" |
9:05 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Elizabeth Haining (University of Birmingham, United Kingdom) "A Novel Knock-In Mouse Reveals an Essential Role for the CLEC-2 hemITAM in Development" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |