Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Paradigm Shifts in Lymphatic Biology and Disease
Discussion Leader: Donald McDonald (University of California, San Francisco, USA)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Growth-Factor Regulation of Brain-Draining Lymphatics"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Brant Weinstein (National Institute of Child Health and Human Development, NIH, USA)
"Novel Lymphatic-Related Cells in the Brain"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Stefan Schulte-Merker (Westfälische Wilhelms-Universität Münster, Germany)
"Molecular and Functional Characterization of Macromolecular Uptake by Meningeal Lymphatic Endothelial Cells"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphatic Vessel Development and Heterogeneity
Discussion Leader: Mark Kahn (University of Pennsylvania, USA)
9:00 am - 9:20 am
Taija Makinen (Uppsala University, Sweden)
"VEGFR3 Regulates Sprouting Lymphangiogenesis Through Cell-Autonomous and Non-Cell-Autonomous Mechanisms"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Natasha Harvey (University of South Australia, Australia)
"Transcriptional Control of Lymphatic Endothelial Cell Identity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Maike Frye (Uppsala University, Sweden)
"Matrix Stiffness Controls Lymphangiogenic Growth Factor Responsiveness and Lymphatic Vessel Formation via GATA2"
10:10 am - 10:15 am
Discussion
10:15 am - 10:35 am
Benjamin Hogan (The University of Queensland, Australia)
"New Cellular Functions and Developmental Pathways for Lymphatic Endothelial Cells in Zebrafish"
10:35 am - 10:45 am
Discussion
10:45 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Guillermo Oliver (Feinberg School of Medicine, Northwestern University, USA)
"Rasip1, a Novel Player Regulating Lymphatic Vessel Lumen Maintenance and Valve Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Tsutomu Kume (Northwestern University School of Medicine, USA)
"Foxc1/Foxc2 Regulation of Postnatal Lymphatic Valve Maturation and Lymphangiogenesis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Michael Davis (University of Missouri School of Medicine, USA)
"Using Optogenetics to Uncover Mechanisms of Pacemaking in the Lymphatic Vessel Wall"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Masanori Hirashima (Kobe University Graduate School of Medicine, Japan)
"Platelets Play a Role in Peripheral Blood-Lymph Partitioning via TGF-Beta"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Melody Swartz (École Polytechnique Fédérale de Lausanne, Switzerland / University of Chicago, USA)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular Regulators of Lymphangiogenesis and Lymphatic Remodeling
Discussion Leader: Taija Makinen (Uppsala University, Sweden)
6:00 pm - 6:20 pm
Mark Kahn (University of Pennsylvania, USA)
"Roles of Lymphatic Vessels in the Postnatal Lung"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Agnes Noel (University of Liege, Belgium)
"New Insights into the Control of VEGFR2/R3 Heterdimerization During Pathological Lymphangiogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Young Hong (University of Southern California, USA)
"New Key Players for Lymphangiogenesis and Lymphatic Identity"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Mark Fuster (University of California, San Diego, USA)
"A Key Proteoglycan Co-Receptor in Lymphatic Remodeling and Dendritic Cell Function"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Masataka Majima (Kitasato University School of Medicine, Japan)
"Role of Prostanoids in Regulation of Pathological Lymphangiogenesis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Organ-Specific Lymphatic Function and Pathology
Discussion Leader: Gou Young Koh (Institute for Basic Science / Korea Advanced Institute of Science and Technology, South Korea)
9:00 am - 9:20 am
Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland)
"Development and Maintenance of Organ-Specific Lymphatic Vasculature"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Donald McDonald (University of California, San Francisco, USA)
"Strategies for Reversing Abnormal Lymphangiogenesis in Mouse Models"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Kathleen Caron (University of North Carolina at Chapel Hill, USA)
"Lymphatic Heterogeneity and Function in Specialized Vascular Beds"
10:20 am - 10:30 am
Discussion
10:30 am - 10:40 am
Joo-Hye Song (Institute for Basic Science, South Korea)
"Role of Microbiota in Lacteal Integrity"
10:40 am - 10:45 am
Discussion
10:45 am - 11:10 am
Coffee Break
11:10 am - 11:30 am
Burkhard Ludewig (Institute of Immunobiology, Kantonsspital St. Gallen, Switzerland)
"Lymphatic Endothelial Cells Control Lymph Node Formation"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
James Moore (Imperial College London, United Kingdom)
"The 3D Architecture of Lymph Node Blood Vessels"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Lu Chen (University of California, Berkeley, USA)
"Ocular Lymphatics and Therapeutic Intervention"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Matthew Burchill (University of Colorado Denver, USA)
"Lymphatic Expansion and Differentiation During Chronic Liver Disease"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatics in the Brain and Beyond
Discussion Leader: Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
6:00 pm - 6:20 pm
Jonathan Kipnis (University of Virginia, USA)
"Role of Meningeal Lymphatics in Neurological Disorders"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Maiken Nedergaard (University of Copenhagen, Denmark / University of Rochester, USA)
"Glymphatic System"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Steven Proulx (ETH Zurich, Switzerland)
"Outflow of Cerebrospinal Fluid Through Lymphatic Vessels Is Increased During Waking Conditions"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Salli Antila (University of Helsinki / Wihuri Research Institute, Finland)
"Development and Plasticity of Meningeal Lymphatic Vessels"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Susan Quaggin (Northwestern University, USA)
"Angiopoietin-Tie2 System for Formation of Schlemm's Canal"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphedema and Congenital Lymphatic Diseases
Discussion Leader: Barbara Garmy-Susini (INSERM, France)
9:00 am - 9:20 am
Miikka Vikkula (de Duve Institute, Université Catholique de Louvain, Belgium)
"Mutations-Related Primary Lymphedema"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Pia Ostergaard (St George's, University of London, United Kingdom)
"Understanding Human Lymphatic Phenotypes Based on Gene Function and Mechanisms"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
Carrie Shawber (Columbia University Medical Center, USA)
"Notch4 Mutant Mice Develop a Lipedema-Like Syndrome Associated with Dermal Lymphatic Defects"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Ines Martinez-Corral (Uppsala University, Sweden)
"New Insights into Mechanisms Underlying PIK3CA-Driven Vascular Malformations from Genetic Mouse Models"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Stanley Rockson (Stanford University School of Medicine, USA)
"Novel Methods for Diagnosis and Treatment of Secondary Lymphedema"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Maxim Itkin (University of Pennsylvania Medical Center, USA)
"Imaging and the Therapeutic Intervention of Lymphatic Flow Disorders"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Brandon Dixon (Georgia Institute of Technology, USA)
"Characterization of Lymphatic Function and Remodeling Response Following Lymphatic Injury"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
Timothy Padera (Massachusetts General Hospital / Harvard Medical School, USA)
"Sustained Collecting Lymphatic Vessel Dysfunction After MRSA Infection"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cross-Talk Between the Lymphatics and the Immune System
Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, USA)
6:00 pm - 6:20 pm
Gwendalyn Randolph (Washington University in St. Louis, USA)
"Chronic Inflammatory Diseases and Recirculation of Lipoproteins Through the Interstitium"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Susan Schwab (New York University School of Medicine, USA)
"Lymphatic-Endothelial S1P and T-Cell Survival"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Beth Tamburini (University of Colorado Anschutz Medical Campus, USA)
"PD-L1 Regulation of Lymphatic Growth and Survival in the Lymph Node During an Immune Response"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
David Jackson (University of Oxford, United Kingdom)
"LYVE-1: A Docking Receptor for Leukocyte Entry and Trafficking in Skin Lymphatics"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Jorge Arasa Aparici (ETH Zurich, Switzerland)
"Transcriptional Profiling of Afferent Lymphatic Capillaries and Collectors Reveals a New Entry Site for Dendritic Cell Migration to Lymph Nodes in Inflammation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Lymphatics in Cardiovascular Medicine and Metabolism
Discussion Leader: Tatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland)
9:00 am - 9:20 am
Melody Swartz (École Polytechnique Fédérale de Lausanne, Switzerland / University of Chicago, USA)
"Inflammatory Lymphangiogenesis Helps Shape Adaptive Immunity: New Insights for Translation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Friedemann Kiefer (European Institute for Molecular Imaging, Germany)
"Novel Tools to Image Lymphatic Vessel Development, Function and Dysfunction"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Brian Wong (Washington University School of Medicine, USA)
"Metabolic Regulation of Lymphatic Development and Lymphangiogenesis"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Barbara Garmy-Susini (INSERM, France)
"Lymphatic System: A Novel Actor in Cancer-Associated Cachexia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Laura Santambrogio (Albert Einstein College of Medicine, USA)
"Role of Tryptophan Metabolites in Lymphatic Endothelium"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Annalisa Zecchin (VIB-KU Leuven Center for Cancer Biology, Belgium)
"The Role of Ketone Body Oxidation in Lymphangiogenesis: Possible Relevance for Lymphedema"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hong Chen (Harvard Medical School, USA)
"Molecular Mechanisms of Lymphangiogenesis in Diabetes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatics and Cancer
Discussion Leader: Mihaela Skobe (Icahn School of Medicine at Mount Sinai, USA)
6:00 pm - 6:30 pm
Michael Detmar (ETH Zurich, Switzerland)
"Tumor-Associated Lymphatic Vessels and Immunosuppression in Cancer"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Anneliese Speak (Wellcome Trust Sanger Institute, United Kingdom)
"Host Regulators of Metastatic Colonization"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Lea Maillat (University of Chicago, USA)
"Role of the Lymphatic Vasculature in Regulating Tumor Exosome Trafficking and Production"
7:25 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
Qiaoli Ma (ETH Zurich, Switzerland)
"Fluid Outflow from the Central Nervous System via Lymphatic Vessels Is Reduced in Glioblastoma"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure