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Lymphatics

Gordon Research Conference

The Growth and Function of Lymphatics for Therapeutic Targeting During Development and Disease

March 1 - 6, 2020

Chairs Kathleen M. Caron and Natasha L. Harvey

Vice Chairs Timothy P. Padera and Taija Makinen

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The 2020 Gordon Research Conference on Lymphatics will bring together leading international scientists and clinicians working across all aspects of lymphatic vessel biology to discuss the latest advances in this exciting and dynamic field. The meeting will feature cutting edge expertise in disciplines including developmental biology, genetics, physiology, immunology, metabolism, mechanotransduction and human disease. The lymphatic vasculature has garnered immense attention over the last decade, fueled by advances in our ability to recognize and manipulate lymphatic vessels, together with discoveries that have illuminated key roles for the lymphatic vasculature in human health and disease. This meeting will serve as a forum to communicate the latest research advances in this field as well as providing the opportunity to build collaborative partnerships between scientists, clinicians, disciplines, industry and philanthropy. Ample opportunities for the presentation of research by early career investigators will be provided. Building on the success of previous years, the 2020 Gordon Research Conference on Lymphatics will be preceded by a Gordon Research Seminar on Lymphatics, themed "Interdisciplinary Perspectives on Lymphatic Function in Neglected Diseases" and organized by Elizabeth Haining and Rene Haegerling. We invite you to join us in Ventura, CA, in March 2020 for the preeminent lymphatic vessel meeting of the year!

Related Meeting

This GRC will be held in conjunction with the "Lymphatics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Building the Lymphatic Vasculature Discussion Leader: Hong Chen (Harvard Medical School, USA)
7:40 pm - 7:45 pm	Opening Remarks
7:45 pm - 8:05 pm	Karina Yaniv (Weizmann Institute of Science, Israel) "Lymphatic Vessels in Organ Growth and Regeneration"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Sarah De Val (University of Oxford, United Kingdom) "Using Enhancer Analysis to Delineate the Transcriptional Regulation of Early Lymphatic Development"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:05 pm	Oliver Stone (University of Oxford, United Kingdom) "Developmental Origins of Lymphatic Endothelial Cells"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Mathias Francois (The University of Sydney, Australia) "Deciphering the Biophysical Rules that Govern Chromatin Navigation of the SOX18 Transcription Factor"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Lymphatics at the Barriers Discussion Leader: Mathias Francois (The University of Sydney, Australia)
9:00 am - 9:20 am	Kari Alitalo (Wihuri Research Institute / University of Helsinki, Finland) "Growth Factors in Lymphatic Development, Disease and Repair"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Jonathan Kipnis (University of Virginia, USA) "Role of Meningeal Lymphatics in Immune Surveillance of the Brain"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Steven Proulx (University of Bern, Switzerland) "In Vivo Imaging of Cerebrospinal Fluid Flow and Clearance Through Lymphatic Vessels"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Taija Makinen (Uppsala University, Sweden) "Pathogenic Mechanisms of Vascular Malformations"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Susan Quaggin (Northwestern University, USA) "Angiopoietin/Tie Signalling in Lymphangiogenesis"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Hasina Outtz Reed (Weill Cornell Medicine, USA) "The Pulmonary Lymphatics: A Role in Lung Injury?"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Emilia Korhonen (University of Helsinki / Wihuri Research Institute, Finland) "Angiopoietin-Tie Signaling in Postnatal Lymphatic Vessel Development"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: Taija Makinen (Uppsala University, Sweden) and Timothy Padera (Massachusetts General Hospital / Harvard Medical School, USA)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Metabolism of Lymphatic Endothelial Cells Discussion Leader: Beth Tamburini (University of Colorado Anschutz Medical Campus, USA)
7:30 pm - 7:50 pm	Sinem Karaman (Wihuri Research Institute / University of Helsinki, Finland) "Lymphangiogenic Signaling Pathway Regulates Adipose and Hepatic Responses in Obesity"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Veronique Angeli (National University of Singapore, Singapore) "Macrophage and Regulation of Lymphatic Function"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Guillermo Oliver (Feinberg School of Medicine, Northwestern University, USA) "The Lymphatic Vasculature in Organ Growth"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Sanjeev Datar (University of California, San Francisco, USA) "Lymphatic Pathophysiology in Congenital Heart Disease with Increased Pulmonary Blood Flow"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Kerstin Wilhelm-Jüngling (Max Planck Institute for Heart and Lung Research, Germany) "Control of Lymphatic Expansion by FOXO Transcription Factors"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	The Mechanics of Lymphatics Discussion Leader: Joseph Rutkowski (Texas A&M University College of Medicine, USA)
9:00 am - 9:20 am	Maike Frye (University Medical Center Hamburg-Eppendorf, Germany) "Regulation of Lymphatic Vessel Integrity"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Michael Davis (University of Missouri School of Medicine, USA) "Mechanisms by Which Pressure Regulates Lymphatic Pumping"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	Sathish Srinivasan (Oklahoma Medical Research Foundation, USA) "Novel Associations Between Lymphedema and Cardiovascular Disorders"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Joshua Scallan (University of South Florida, USA) "Lymphatic Junction Molecules as Signaling Regulators"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Selected from Poster Abstracts: An Zwijsen (KU Leuven, Belgium) "BMP-SMADs Promote Lymphatic Vessel Stabilization by Tuning WNT Signaling"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	David Zawieja (Texas A&M University, USA) "Impact of the Space Environment on Lymphatic Function"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Pierre-Yves von der Weid (University of Calgary, Canada) "Lymphatics and Statins: A Lova-Hate Story"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Genetics and Pathophysiology of Rare Lymphatic Diseases Discussion Leader: Michael Dellinger (University of Texas Southwestern Medical Center, USA)
7:30 pm - 7:50 pm	Pia Ostergaard (St George's, University of London, United Kingdom) "Dealing with Variants of Unknown Significance (VUS): Functional Characterization of Variants in Primary Lymphoedema Patients"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Miikka Vikkula (de Duve Institute, UCLouvain, Belgium) "Heterogeneous Pathophysiological Basis of Primary Lymphedema"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Rachelle Crescenzi (Vanderbilt University Medical Center, USA) "Sodium Imaging: Lessons Learned from Lipedema and Lymphedema"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Rene Haegerling (Charité - Universitätsmedizin Berlin, Germany) "The Underlying Histological Characteristics of Lymphedema and Lipedema"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Joseph Rutkowski (Texas A&M University College of Medicine, USA) "Lymphangiogenic Signaling in Diseases of the Cardio-Renal Axis"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Immune Cell Navigation to and from Lymphatics Discussion Leader: Timothy Padera (Massachusetts General Hospital / Harvard Medical School, USA)
9:00 am - 9:20 am	Mark Kahn (University of Pennsylvania, USA) "Bugs, Lymph and Clots"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Cornelia Halin Winter (ETH Zurich, Switzerland) "Leukocyte Migration and Immune Regulation Within Afferent Lymphatics"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: Simon Stritt (Uppsala University, Sweden) "Integrin avβ3 Signaling Regulates Developmental Lymphangiogenesis in Mice"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	Selected from Poster Abstracts: Janette Kazenwadel (University of South Australia, Australia) "Lymphatic Endothelial Cell Identity Is Controlled by a GATA2 Bound Enhancer"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Gwendalyn Randolph (Washington University in St. Louis, USA) "Transport of Cellular and Molecular Cargo via Intestinal Lymphatics and Its Association with Inflammatory Diseases"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	Timothy Padera (Massachusetts General Hospital / Harvard Medical School, USA) "The Role of the Lymphatic System in Cancer Progression"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	Selected from Poster Abstracts: Ching-Ling (Ellen) Lien (Saban Research Institute, Children's Hospital Los Angeles / University of Southern California, USA) "The Roles of Cardiac Lymphatic Vessels in Zebrafish Heart Development and Regeneration"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Friedemann Kiefer (European Institute for Molecular Imaging (EIMI), Germany) "Primordial Lymph Vessel Formation in the Mouse"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lymphangiogenesis in Overdrive: Inflammation and Cancer Discussion Leader: Barbara Garmy-Susini (Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM, France)
7:30 pm - 7:40 pm	Zoltan Jakus (Semmelweis University, Hungary) "Studying the Mechanisms that Prepare the Developing Lung for Inflation at Birth"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	Laura Santambrogio (Weill Cornell Medicine, USA) "A Novel Biogenic Amine Released by Lymphatic Endothelial Cells Restrains Inflammation"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	Selected from Poster Abstracts: Carrie Shawber (Columbia University Irving Medical Center, USA) "A Precision Medicine Approach to Understanding Congenital Lymphatic Anomalies"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	Selected from Poster Abstracts: Giorgia Jurisic Snijder (Novartis Institutes for Biomedical Research, Switzerland) "The Natural Product Iripallidal Promotes Lymphangiogenesis in Response to Injury via RASGRP3"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Philip King (University of Michigan Medical School, USA) "RASA1-Mediated Control of Lymphatic and Blood Vascular Development and Function"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Natalie Trevaskis (Monash Institute of Pharmaceutical Sciences, Monash University, Australia) "Mesenteric Lymphatic Dysfunction Promotes Insulin Resistance and Represents a Potential Novel Treatment Target in Obesity"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Stephanie Hugues (University of Geneva Medical School, Switzerland) "MHC Class II Expression by Tumoral Lymphatics Is Required for Tumor Specific Signature and Suppressive Functions of Treg Cells"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm	Lymphatic Vessel Heterogeneity in the Era of Single Cell Analysis Discussion Leader: Taija Makinen (Uppsala University, Sweden)
9:00 am - 9:20 am	Beth Tamburini (University of Colorado Anschutz Medical Campus, USA) "Reprogramming of the Liver Lymphatic Endothelium During Chronic Liver Disease"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	Benjamin Hogan (Peter MacCallum Cancer Centre, Australia) "Zebrafish Lymphatic Endothelial Cell Specification at Single Cell Resolution"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	Selected from Poster Abstracts: Maria Ulvmar (Uppsala University, Sweden) "Single-Cell Transcriptional Cross-Mapping of the Mouse and Human Lymph Node Lymphatic Vasculature"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	Brant Weinstein (National Institute of Child Health and Human Development, NIH, USA) "Novel Insights into Lymphatic Development from the Zebrafish"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	Tsutomu Kume (Feinberg School of Medicine, Northwestern University, USA) "Foxc Transcription Factors in Organ-Specific Lymphatic Function"
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Young Hong (University of Southern California, USA) "Piezo1-Mediated Activation of Lymphatic Function and Growth"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Selected from Poster Abstracts: Wenjing Xu (University of North Carolina at Chapel Hill, USA) "Identifying Novel Modifier Genes Related to Naturally-Occurring Heterogeneity of Lymphatics Within a Diverse Genetic Population"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Engineering and Therapeutics for the Lymphatic System Discussion Leader: Laura Santambrogio (Weill Cornell Medicine, USA)
7:30 pm - 7:50 pm	Chris Porter (Monash University, Australia) "Targeting the Mesenteric Lymph Using Triglyceride-Mimetic Prodrugs"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	Brandon Dixon (Georgia Institute of Technology, USA) "Lymphatic Tissue Engineering"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	Jan Kitajewski (University of Illinois at Chicago, USA) "Cell Fate Mechanisms that Drive Lymphangiogenesis"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Selected from Poster Abstracts: Donny Hanjaya-Putra (University of Notre Dame, USA) "Engineering Biomaterials for Lymphatic Morphogenesis"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Selected from Poster Abstracts: Barbara Garmy-Susini (Institute of Cardiovascular and Metabolic Diseases (I2MC), INSERM, France) "Theralymph: An Innovative H2020 Program to Perform Gene Therapy for Lymphedema"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13 HL152571-01 from the National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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