Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Emerging Discoveries in Lymphatic Research
Discussion Leader: Maike Frye (University Medical Center Hamburg-Eppendorf, Germany)
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
Tatiana Petrova (University of Lausanne, Switzerland)
"Mechanisms of Adult Lymphatic Renewal and Repair"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Gou Young Koh (Institute for Basic Science and Korea Advanced Institute of Science and Technology, South Korea)
"Unexpected Discovery of Prox1+ Vessels in Two Hidden Places"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Natalie Trevaskis (Monash Institute of Pharmaceutical Sciences, Monash University, Australia)
"Gut Lymph Model Based Treatment Strategies to Alleviate Organ Failure in Acute and Critical Diseases"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Melody Swartz (University of Chicago, United States)
"Lymph Node Lymphatics Help Shape the Immune Response"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lymphatic Vessel Heterogeneity in Health and Disease
Discussion Leader: Pia Ostergaard (St George's, University of London, United Kingdom)
9:00 am - 9:20 am
Kari Alitalo (University of Helsinki and Wihuri Research Institute, Finland)
"Lymphangiogenic Growth Factor Mechanisms and Translation to Therapeutics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Carrie Shawber (Columbia University Irving Medical Center, United States)
"Notch4 Functions in Organ-Specific Lymphatic Vessel Maintenance"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Miikka Vikkula (de Duve Institute / UCLouvain, Belgium)
"Novel Genetic Findings on Heterogeneity of Primary Lymphedema"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Salli Antila (University of Helsinki / Wihuri Research Institute, Finland)
"Manipulation of Dural Lymphatic Vessels in Alzheimer’s Disease-Related Amyloid Pathology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Jasmin Herz (Washington University in St. Louis, United States)
"The Role of CNS-Draining Lymphatics in Neurodegeneration"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Friedemann Kiefer (European Institute for Molecular Imaging (EIMI) / University of Münster, Germany)
"Lymphatic Vessels of Peritoneal Organs"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Gregory Westcott (Beth Israel Deaconess Medical Center, United States)
"Adipose-Lymphatic Interactions in Obesity and Lymphedema at a Single-Cell Resolution"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Hasina Outtz Reed (Weill Cornell Medicine, United States)
"Lymphatic Dysfunction in the Pathogenesis of Emphysema"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Dennis Jones (Boston University School of Medicine, United States) and Natasha Harvey (University of South Australia, Australia)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatic Vessel Morphogenesis: From Progenitors to Functional Vessels
Discussion Leader: Ben Hogan (Peter MacCallum Cancer Centre, Australia)
6:00 pm - 6:20 pm
Brant Weinstein (National Institute of Child Health and Human Development, United States)
"Studying the Origins of Lymphatics and Lymphatic-Related Cells using the Zebrafish"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Elizabeth Mason (Peter MacCallum Cancer Centre, Australia)
"Single Cell Profiling Reveals the Regulation of Venous to Lymphatic Endothelial Cell Differentiation Controlled by Prox1 in the Developing Embryo"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Oliver Stone (University of Oxford, United Kingdom)
"Developmental Origins of Lymphatic Endothelial Cells"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Stanislao Travisano (Children Hospital of Los Angeles, United States)
"Single Nuclei Multiomic Analyses Identify Novel Human Cardiac Lymphatic Progenitors in the Epicardium"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Yoshiaki Kubota (Keio University School of Medicine, Japan)
"Blood and Lymphatic Endothelial Cell Plasticity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Lymphatic Drainage: Mechanism, Mechanics, Imaging and Emerging Therapeutic Approaches
Discussion Leader: David Zawieja (Texas A&M University, United States)
9:00 am - 9:20 am
Brandon Dixon (Georgia Institute of Technology, United States)
"Targeted Therapies for Enhancing Lymphatic Function in Lymphedema"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Pauliina Hartiala (Turku University Hospital/ University of Turku, Finland)
"Phase II Lymfactin® Study; a Double-blind, Placebo-controlled, Randomized Study to Assess the Efficacy, Safety and Tolerability of Lymfactin® Treatment for Breast Cancer-Related Lymphedema"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Arushri Swarup (Imperial College London, United Kingdom)
"Design of a Growth Factor Releasing Implantable Device to Prevent the Onset of Breast Cancer Related Lymphoedema"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
Michael Davis (University of Missouri School of Medicine, United States)
"KATP Channels in Lymphatic Function"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Maxim Itkin (University of Pennsylvania, United States)
"Current Status of Lymphatic Flow Disorders: Intersection of Clinical and Basic Science"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Jorge Castorena (Tulane University, United States)
"Obesity-induced Lymphatic Valve Dysfunction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Rahul Ravindran (University of Oxford, United Kingdom)
"Characterization of the Mouse Colon Lymphatic Network Architecture and Transit from the Colonic Submucosa"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Tara Karnezis (St. Vincent's Institute of Medical Research, Australia)
"Key Signalling Networks and Dysregulated in Patients with the Adipose Disorder, Lipoedema"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Decisions on Lymphatic Endothelial Cell Identity, Quiescence and Growth
Discussion Leader: Hong Chen (Harvard Medical School, United States)
6:00 pm - 6:20 pm
Natasha Harvey (University of South Australia, Australia)
"Dissecting the Mechanisms by which Lymphatic Endothelial Identity is Transcriptionally Controlled"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Maike Frye (University Medical Center Hamburg-Eppendorf, Germany)
"The Phosphodiesterase 2A Regulates Lymphatic Development Through Modulation of a Crosstalk Between cGMP and NOTCH Signaling"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Kaska Koltowska (Uppsala University, Sweden)
"Developmental Programming of Lymphatic Endothelial Progenitors"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Michael Dellinger (University of Texas Southwestern Medical Center, United States)
"Hyperactive KRAS Signaling Impairs Lymphatic Valve Morphogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Michael Potente (Berlin Institute of Health, Germany)
"Metabolic Decisions Controlling Endothelial Quiescence and Growth"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunomodulatory Functions of Lymphatic Vessels
Discussion Leader: David Jackson (University of Oxford, United Kingdom)
9:00 am - 9:20 am
Cornelia Halin Winter (ETH Zurich, Switzerland)
"Dendritic Cell Interactions with and within Lymphatic Capillaries"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Shan Liao (University of Calgary, Canada)
"The Role of Lymph Flow in Innate Immunity in the Lymph Node"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Beth Tamburini (University of Colorado School of Medicine, United States)
"New Insights into Lymphatic Endothelial Cell Antigen Archiving and the Influence on Immune Memory"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Milena Petkova (Uppsala University, Sweden)
"New Capillary Lymphatic Endothelial Cell Subtype as a Driver of Lymphatic Malformation Pathology"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stephanie Hugues (University of Geneva Medical School, Switzerland)
"Cross-Talk Between Lymphatics and Immune Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Coraline Heron (Normandy University, France)
"Regulation and Impact of Cardiac Lymphangiogenesis in Pressure-overload-induced Heart Failure"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
Michael Detmar (ETH Zurich, Switzerland)
"The Role of Lymphatics in Inflammation"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Lymphatic Vessels in Cancer: Therapeutic Opportunities
Discussion Leader: Agnes Noel (University of Liege, Belgium)
6:00 pm - 6:20 pm
Amanda Lund (New York University Grossman School of Medicine, United States)
"Investigating Lymphatic Transport in Anti-tumor Immunity and Metastasis"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Meghan OMelia (Massachusetts General Hospital/Harvard Medical School, United States)
"Quality of CD8+ T Cell Immunity Evoked in Lymph Nodes is Compartmentalized by Route of Antigen Transport and Functional in Tumor Context"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Maria Ulvmar (Uppsala University, Sweden)
"Vascular Changes in Tumor-Draining Lymph Nodes with Implications for Tumor Immunity"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Barbara Garmy-Susini (INSERM, France)
"15-Lipoxygenase Drives Inflammation Resolution and Treg Trafficking in Lymphedema"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Haley du Bois (New York University School of Medicine, United States)
"Melanoma-shed, Lymph-borne CSPG4 Conditions the Pre-Metastatic Lymph Node Niche"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Dennis Jones (Boston University School of Medicine, United States)
"The Consequences of Lymph Node Metastasis on Anti-Tumor Immunity"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Signalling Pathways for Lymphatic Vessel Growth and Pathology
Discussion Leader: Stefan Schulte-Merker (Westfälische Wilhelms-Universität Münster, Germany)
9:00 am - 9:20 am
Anne Eichmann (Yale School of Medicine, United States)
"Lymphatic Endothelial Sprouting and Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Philip King (University of Michigan Medical School, United States)
"A Specific Requirement for Physical Interaction Between EPHB4 and RASA1 for the Development and Function of Lymphatic Vessel Valves"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Sathish Srinivasan (Oklahoma Medical Research Foundation, United States)
"Signaling Pathways Regulating Lymphatic Vascular Growth"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Pia Ostergaard (St George's, University of London, United Kingdom)
"Analysis of Genomics England 100,000 Genomes Data Associate the Transcription Factor ERG with Primary Lymphoedema"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mark Kahn (University of Pennsylvania, United States)
"Novel Mechanisms of VEGFR3 Regulation During Vascular Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Young Hong (University of Southern California, United States)
"Molecular Dissection of Fluid-Induced Mechanotransduction Pathway in Lymphatic Endothelial Cells"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Thomas Clahsen (University of Cologne, Faculty of Medicine and University Hospital, Germany)
"Cystathionine ß-synthase as Novel Endogenous Regulator of Lymphangiogenesis via Modulating VEGF receptor 2 and 3"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Kathleen Caron (University of North Carolina at Chapel Hill, United States)
"Scaffolding of Lymphatic Endothelial Cell Signaling Nodes"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Beyond Lymphangiogenic Pathways
Discussion Leader: Barbara Garmy-Susini (INSERM, France)
6:00 pm - 6:20 pm
Guillermo Oliver (Northwestern University, United States)
"Lymphatics and Lymphangiocrine Factors in Organ Growth and Repair"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Brisa Palikuqi (UCSF, United States)
"Lymphangiocrine Signals are Required for Proper Intestinal Repair after Cytotoxic Injury"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Laura Santambrogio (Weill Cornell Medicine, United States)
"Physiological and Immunological Role of the Lymph"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Sanjeev Datar (University of California, San Francisco, United States)
"Enteral Treatment with a Mitochondrially-targeted Antioxidant Preserves Pulmonary Lymphatic Function in an Ovine Model of Congenital Heart Disease with Increased Pulmonary Blood Flow"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Stanley Rockson (Stanford University School of Medicine, United States)
"How Does a Lymphatic Diagnosis Influence Pathologic Interrelationships?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
