Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:15 pm - 4:00 pm
Keynote Session: Heterogeneous Molecular Pathophysiology Behind Primary Lymphedema
Discussion Leaders: Claudia Carlantoni (University Medical Centre Hamburg (UKE), Germany)
3:15 pm - 3:45 pm
Miikka Vikkula (de Duve Institute / UCLouvain, Belgium)
"Novel Insights into Pathophysiology of Primary Lymphedema"
3:45 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
The Organ-Specific Lymphatic Vasculature
Discussion Leaders: Elizabeth Mason (Peter MacCallum Cancer Centre, Australia) and Keith Keane (University of Calgary, Canada)
5:30 pm - 5:45 pm
Virginia Panara (Uppsala University, Sweden)
"Distinct Cis-Regulatory Elements Drive prox1a Expression in Specific Lymphatic Vascular Beds"
5:45 pm - 5:50 pm
Discussion
5:50 pm - 6:05 pm
Melina Hußmann (Institute for Cardiovascular Organogenesis and Regeneration, Germany)
"SVEP1 and Tie1 Genetically Interact and Affect Aspects of Facial Lymphatic Development in a Vegfc-Independent Manner"
6:05 pm - 6:10 pm
Discussion
6:10 pm - 6:25 pm
Tenny Mudianto (NYU Langone Health, United States)
"Lymph Node Lymphangiogenesis Facilitates Anti-Viral Humoral Immunity"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:45 pm
Erin Crossey (Boston University School of Medicine, United States)
"Elucidating the Role of Hippo Signaling During Influenza-induced Lymphangiogenesis"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
Kazim Ogmen (St.Georges, University of London, United Kingdom)
"In Vitro Characterization of EPHB4 Variants: Mechanistic Studies of EPHB4-associated Primary Lymphoedema"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
Ana Angulo-Urarte (Josep Carreras Leukaemia Research Institute, Spain)
"Modeling PIK3CA-related Overgrowth Disorders in Mice: The Lymphatic Compartment as the Most Responsive to High PI3K Activity-related Pathogenesis"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Molecular Mechanisms Orchestrating Lymphatic Development in Health and Disease
Discussion Leaders: Coraline Heron (Normandy University, France) and Lorenz M. Brunner (ETH Zürich, Switzerland)
9:00 am - 9:15 am
Marleen Gloger (Uppsala University, IGP, Sweden)
"Spatio-Temporal Control of Lymphatic Endothelial Cell Proliferation During Embryonic Development"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Kazuhide Okuda (Peter MacCallum Cancer Centre, Australia)
"The RNA Helicase Ddx21 Controls Vegfc-Driven Developmental Lymphangiogenesis by Balancing Endothelial Cell Ribosome Biogenesis and p53 Function"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Nathan Nelson-Maney (UNC School of Medicine, United States)
"Orphan G-protein Coupled Receptor GPRC5B is Critical for Lymphatic Development"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Silke Kreher (Max Planck Institute for Heart and Lung Research, Germany)
"MATR3-based Alterative Splicing is Indispensable for Lymphangiogenesis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Hans Schoofs (Uppsala University, Sweden)
"Clonal Origin of Pik3ca-Driven Lymphatic Malformations"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Ege Ozkan Sackey (St. George's University of London, United Kingdom)
"A Novel Causative Gene for Autosomal Dominant Primary Lymphoedema"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Emerging Technologies to Study Lymphatics
Discussion Leaders: Anna Kolarzyk (Cornell University, United States) and Daniel Watson (Imperial College London, United Kingdom)
1:30 pm - 1:45 pm
Matthew Stephens (University of Calgary, Canada)
"Generating DNA Aptamers to Modulate Inflammation"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Yarelis Gonzalez-Vargas (Georgia Institute of Technology and Emory University, United States)
"Bioengineered 3D in Vitro Platform Promotes Lymphatic Network Sprouting from a Primary Cell-Based Spheroid Model of the Collecting Vessel and Lymphatic Malformations"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Robert Sibley (Stanford University, United States)
"Iron Oxide Nanoparticle Magnetic Resonance Lymphangiography (ION-MRL): A Simplified Technique for Evaluating the Peripheral and Central Lymphatic System"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
