SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Membrane dynamics and signalling |
| Discussion Leader: Elizabeth Conibear (University of British Columbia, Canada) |
7:40 pm - 8:00 pm | Paolo di Fiore (The FIRC Institute of Molecular Foundation, Milan, Italy)
"Endocytic proteins in the maintenance of the stem cell compartment and in cancer" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:20 pm | Marcel Mettlen (Scripps)
"Cargo and dynamin regulate clathrin coated pit maturation" |
8:20 pm - 8:25 pm | Discussion |
8:25 pm - 8:35 pm | Shawn Ferguson (Yale)
"Genetic dissection of the endocytic and actin regulatory functions of dynamins" |
8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Andreas Mayer (Lausanne)
"Organelle homeostasis and the balance of membrane fission and fusion" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:25 pm | Peter McPherson (McGill, Montreal)
"Linking COP1 trafficking to neurodegenerative disease" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Vesicle formation |
| Discussion Leader: Margaret (Scottie) Robinson (University of Cambridge, UK) |
9:00 am - 9:20 am | Greg Payne (David Geffen School of Medicine at UCLA)
"Structural features of endocytic coat formation in yeast" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Linton Traub (University of Pittsburgh)
"Regulation of yolk precursor endocytosis during invertebrate oocyte development" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | David Drubin (University of California, Berkeley)
"Harnessing actin dynamics for endocytic trafficking events" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Christopher Esk (UCSF)
"A role for the CHC22 isoform of clathrin heavy chain in glucose metabolism by human skeletal muscle" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Beverley Wendland (John Hopkins)
"A new conserved family of endocytic adaptor proteins" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Elizabeth Conibear (University of British Columbia)
"Identification of new AP-1 regulatory factors in yeast" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Tanja Maritzen (Berlin)
"Regulation of recycling endosomal membrane traffic by gamma-BAR complex formation with the clathrin adaptor AP-1 and kinesin KIF5" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Motors and vesicle transport |
| Discussion Leader: Judith Klumperman (University Medical Centre Utrecht) |
7:30 pm - 7:50 pm | Jacques Neefjes (Netherlands Cancer Institute)
"Molecular mechanism of cholesterol control of late endosomal dynein motor driven movement" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Folma Buss (University of Cambridge, UK)
"The different roles of myosin VI along the endocytic pathway" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Gero Steinberg (Exeter)
"Motors in endosome trafficking in the model system Ustilago maydis" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Graca Raposo (Institut Curie, Paris)
"Cooperation between Adaptors and Motors for the biogenesis of melanosomes" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lysosomal degradative pathways: multivesicular bodies and autophagosomes |
| Discussion Leader: Harald Stenmark (The Norwegian Radium Hospital) |
9:00 am - 9:20 am | Scott Emr (Cornell Institute for Cell and Molecular Biology)
"ESCRTing proteins in the endocytic pathway" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Sylvie Urbe (University of Liverpool, UK)
"Deubiquitination enzymes in the endocytic pathway" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Nia Bryant (Glasgow University)
"A role for ubiquitination in the insulin-regulated trafficking of GLUT4" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Phyllis Hanson (St Louis)
"Role and regulation of ESCRTIII proteins in multivesicular body biogenesis" |
10:25 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Clare Futter (University College London)
"EGF-stimulated intralumenal vesicle formation within multivesicular bodies" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Wes Sundquist (University of Utah)
"The Biochemistry of HIV Budding" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Fulvio Reggiori (University Medical Center, Utrecht)
"Atg9 and autophagosome biogenesis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lysosomal diseases |
| Discussion Leader: Elizabeth Neufeld |
7:30 pm - 7:40 pm | Elizabeth Neufeld (UCLA)
"Perspectives and mucolipodosis" |
7:40 pm - 7:45 pm | Discussion |
7:45 pm - 8:05 pm | Allessandra d'Azzo (St. Jude Children's Research Hospital, Memphis)
"Roles of lysosomal enzymes beyond degradation" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Eline van Meel (Utrecht)
"MPR-independent lysosomal transport pathways of soluble lysosomal hydrolases" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Dan Metcalf (UCL, London)
"Altered trafficking of a mannose-6-phosphate receptor can explain how loss of CLN3 causes Batten disease" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Michael Schwake (Kiel)
"LIMP-2 is a receptor for lysosomal mannose-6-phosphate independent targeting of glucocerebrosidase" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Fran Platt (University of Oxford, UK)
"Niemann-Pick disease type C: insights into pathogenesis and new approaches to therapy" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endocytic organelles in development |
| Discussion Leader: Sandra Schmid (The Scripps Research Institute) |
9:00 am - 9:20 am | Marcos Gonzalez-Gaitan (University of Geneva)
"Sara Endosomes in asymmetric cell division" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Barth Grant (Rutgers University)
"Regulation of Endocytic Recycling in Caenorhabditis elegans" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Jiri Friml (Ghent University, Belgium)
"Endocytosis and Cell Polarity in Plants" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Mark Field (University of Cambridge)
"Endocytosis of trans-membrane domain proteins in trypanosomes is mediated by an evolutionary conserved mechanism based on ubiquitylation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Terry O'Halloran (University of Texas)
"Epsin and Hip1r-dependent coupling of dynamic actin to coated pit scission in Dictyostelium" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Rytis Prekeris (University of Colorado)
"Rab11-FIP3 protein regulates the targeting of recycling endosomes to the cleavage furrow during mitotic cell division" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | New Directions |
| Discussion Leader: Frances Brodsky (UCSF) |
7:30 pm - 7:50 pm | Scottie Robinson (CIMR, Cambridge, UK)
"Rapid inactivation of coat proteins by rerouting to mitochondria" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Subba Rao Gangi Setty (U. Penn)
"Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Vas Ponnambalam (Leeds, UK)
"The LOX-1 Scavenger Receptor: Translating Cell Biology into Medicine" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Janice La Plante (Harvard)
"The lysosomal cation channel mucolipin 1 co-ordinates a novel form of intercellular communication involving the cell to cell transfer of organelles through nanotubular membrane bridges" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Roberto Weigert (NIH)
"Imaging the internalization and trafficking of fluorescently conjugates molecules in live rats by using intravital two-photon microscopy" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Reuben Aguilar (Purdue)
"The yeast endocytic protein Epsin-2 (Ent2) displays specific signaling functions towards cell division pathways" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pathogens, defense and polarized secretion of endocytic organelles |
| Discussion Leader: Marcos Gonzalez-Gaitan (University of Geneva) |
9:00 am - 9:20 am | Gisou van der Goot (Global Health Institute, Lausanne, Switzerland)
"Unexpected encounter between Wnt signaling and anthrax toxin endocytosis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Mark Marsh (University College London)
"Assembly and release of HIV in macrophages" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Sanford Simon (Rockefeller)
"Visualising the biogenesis of individual HIV-1 virions in live cells" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:20 am | Jennifer Stow (University of Queensland, Australia)
"Recycling endosomes and cytokine secretion" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Heike Folsch (Northwestern University)
"Rab13 regulates membrane trafficking between the TGN and recycling endosomes in polarized epithelial cells" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Hiroshi Ohno (Yokohama, Japan)
"GPI-anchored protein glycoprotein 2 mediates transcytosis of type 1 fimbriated bacteria in intestinal M cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Lecture in honor of Alex Novikoff |
7:30 pm - 8:15 pm | Ari Helenius (ETH Zurich)
"Probing the endocytic pathway through study of mechanisms of virus infection" |
8:15 pm - 8:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |