Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Endocytic Machinery at the
Plasma Membrane |
| Discussion Leaders: Sandra Schmid (University of Texas Southwestern Medical Center, USA) and Mark Von Zastrow (University of California, San Francisco, USA) |
7:40 pm - 8:00 pm | Volker Haucke (Leibniz-Institut für Molekulare Pharmakologie, Germany) "Phosphoinositide Conversion Within the Endolysosomal System" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Ludger Johannes (Institut Curie, France) "Using Glycosphingolipids to Build Endocytic Pits in Clathrin-Independent Endocytosis" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Margaret Robinson (University of Cambridge, United Kingdom) "Coated Vesicle Adaptors" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Sara Sigismund (IFOM, The FIRC Institute for Molecular Oncology Foundation, Italy) "ER-PM Contact Sites Control EGFR Endocytosis" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endosomal Sorting and
Recycling |
| Discussion Leaders: Elizabeth Conibear (University of British Columbia, Canada) and Scott Emr (Cornell University, USA) |
9:00 am - 9:20 am | Peter Cullen (University of Bristol, United Kingdom) "Molecular Mechanisms of Endosomal Cargo Sorting and Export" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Julie Donaldson (National Heart, Lung, and Blood Institute, NIH, USA) "Sorting of Endosomal Cargo: Role of Cytoskeleton and Motors" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Manojkumar Puthenveedu (Carnegie Mellon University, USA) "GPCR Localization and Signaling in Endosomal Recycling Microdomains" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA) "Ultrafast Endocytosis of Synaptic Vesicles" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Julie Brill (The Hospital for Sick Children, Canada) "Regulation of Endosomal Sorting and Recycling by PI4P" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Aitor Hierro (CIC bioGUNE, Spain) "Cargo-Specific Sorting from Endosomes" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Zuzana Kadlecova (University of Texas Southwestern Medical Center, USA) "Hierarchical Allosteric Regulation of AP2 Activity Controls Clathrin-Mediated Endocytosis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Exploiting the Endocytic
Machinery During Host-Pathogen Interactions |
| Discussion Leaders: Sergio Grinstein (Hospital for Sick Children, Canada) and Fabienne Paumet (Thomas Jefferson University, USA) |
7:30 pm - 7:50 pm | Nihal Altan-Bonnet (National Institutes of Health, USA) "Enteroviruses Transmission Through PS Vesicles" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Mark Marsh (University College London, United Kingdom) "IFITM Proteins - Endosomal Broad-Spectrum Inhibitors of Virus Entry" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Nels Elde (University of Utah, USA) "Adaptations Blocking Viral Exploitation of the ESCRT Pathway" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Julie Magarian Blander (Icahn School of Medicine at Mount Sinai, USA) "Regulation of Vesicular Traffic for Meeting the Demands of Cross-Presentation" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Shaeri Mukherjee (University of California, San Francisco, USA) "Bacterial Manipulation of the Host Unfolded Protein Response" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Dysregulation of Endosomal
and Lysosomal Trafficking During Cancer and Other Pathologies |
| Discussion Leaders: Alexander Sorkin (University of Pittsburgh School of Medicine, USA) and JoAnn Trejo (University of California, San Diego, USA) |
9:00 am - 9:20 am | Philippe Chavrier (Institut Curie, France) "Exocytosis from Late Endosomes Drives MT1-MMP Digest-on-Demand Response During Breast Cancer Invasion" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Victor Faundez (Emory University, USA) "Genealogy Based Inference of Cellular Mechanisms in Complex Disorders" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Doug Brooks (University of South Australia, Australia) "Altered Endosome Cell Biology in Prostate Cancer" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Rosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA) "Endocytosis and Signaling During Neurodegeneration" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Alissa Weaver (Vanderbilt University School of Medicine, USA) "Regulation of Multivesicular Body Trafficking and Secretion in Cancer" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Chiara Zurzolo (Pasteur Institute, France) "Lysosomes Mediate the Transfer of Pathogenic Alpha Synuclein Fibrils Between Neurons in Tunneling Nanotubes (TNTs)" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Florian Froehlich (University of Osnabrück, Germany) "Endosomal Trafficking in Sphingolipid Homeostasis and Its Implications in Neurodegenerative Disorders" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Metabolism and Related
Diseases |
| Discussion Leaders: Frances Brodsky (University of California, San Francisco, USA / University College London, United Kingdom) and Mara Duncan (University of Michigan, USA) |
7:30 pm - 7:50 pm | Andrea Ballabio (Telethon Institute of Genetics and Medicine, Italy) "Lysosome-to-Nucleus Signaling" |
7:50 pm - 7:55 pm | Discussion |
7:55 pm - 8:15 pm | Amira Klip (University of Toronto, Canada) "Insulin Transcytosis in Human Microvascular Endothelial Cells" |
8:15 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Jennifer Lippincott-Schwartz (Janelia Research Campus, Howard Hughes Medical Institute, USA) "Mechanisms of Lipid Droplet Autophagy and Its Role in Yeast Lifespan Extension" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:05 pm | Bao-Liang Song (Wuhan University, China) "Mechanisms of Intracellular Cholesterol Transport" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Stephane Camus (University College London, United Kingdom) "CHC22 Clathrin Controls an Unconventional Secretory Pathway to Form the Insulin-Responsive GLUT4 Storage Compartment" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms of Lysosomal Degradation and Autophagy |
| Discussion Leaders: Olivia Majer (University of California, Berkeley, USA) and Christian Ungermann (University of Osnabrück, Germany) |
9:00 am - 9:20 am | Markus Babst (University of Utah, USA) "Regulation of Nutrient Transporters by Lipid Domains" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Vojo Deretic (University of New Mexico Health Sciences Center, USA) "Autophagy - Multiple Relationships with Lysosomes" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Mark McNiven (Mayo Clinic, USA) "Lipophagic Regulation by Large and Small GTPases" |
10:15 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:10 am | Haoxing Xu (University of Michigan, USA) "Ion Channels in the Lysosome: Opening the Gate to the Cell's Recycling Center" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Richard Youle (National Institute of Neurological Disorders and Stroke, NIH, USA) "Downstream Steps of Mitophagy: Cargo-Centric Autophagosome Biogenesis and Lysosomal Fusion" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Phyllis Hanson (Washington University School of Medicine in St. Louis, USA) "New Functions for ESCRT-III?" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Amy Kiger (University of California, San Diego, USA) "Rab2 Function in Autophagy and T-Tubule Membrane Remodeling" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Late-Breaking Topics |
| Discussion Leaders: Tom Kirchhausen (Harvard Medical School, USA) and Lois Weisman (University of Michigan, USA) |
7:30 pm - 7:50 pm | Toyoshi Fujimoto (Nagoya University Graduate School of Medicine, Japan) "Lipids and Lipid Domains of the Yeast Vacuole" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Srigokul Upadhyayula (Harvard Medical School, USA) "Cellular Dynamics Imaged in Real Time and in 3D Using Lattice Light-Sheet Microscopy" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Christophe Lamaze (Institut Curie, France) "EHD2 Controls Breast Cancer Aggressiveness Through Caveolae Mechanotransduction" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Mary Munson (University of Massachusetts Medical School, USA) "Architecture of the Yeast Exocyst Complex" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Chris Westlake (National Cancer Institute, NIH, USA) "Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis Initiation" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lysosomes, and Lysosome-Related Organelles |
| Discussion Leaders: Robert Piper (University of Iowa, USA) and Angela Wandiger-Ness (University of New Mexico, USA) |
9:00 am - 9:20 am | Norma Andrews (University of Maryland, USA) "Lysosomes and Endocytosis as Agents of Plasma Membrane Repair" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Juan Bonifacino (National Institute of Child Health and Human Development, NIH, USA) "Mechanisms and Functions of Lysosome Positioning" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:15 am | Roberto Zoncu (University of California, Berkeley, USA) "Molecular Mechanisms of Nutrient Sensing by the Lysosome" |
10:15 am - 10:25 am | Discussion |
10:25 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Michael Marks (Children's Hospital of Philadelphia, USA) "Hermansky-Pudlak Syndrome and SNARE Dynamics During Melanosome Maturation" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Graca Raposo (Institut Curie, France) "Endocytosis-Exocytosis in Cell Cell Communication in Skin Pigmentation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:20 pm | Gillian Griffiths (Cambridge Institute for Medical Research, United Kingdom) "Mechanisms Controlling Lysosomal Secretion in Immune Cells" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Organization and Function of the Endosomal System: From Cells to Tissues |
| Discussion Leader: Roberto Weigert (National Cancer Institute, NIH, USA) |
7:30 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 8:45 pm | Marino Zerial (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) "Molecular Mechanisms of Endosome Biogenesis, Tethering and Fusion" |
8:45 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | General Discussion |
9:15 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |