Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Lysosomes and Endomembranes: Functions, Identity and as a Niche for Pathogens
Discussion Leaders: Philip Stahl (Washington University School of Medicine, USA) and JoAnn Trejo (University of California, San Diego, USA)
7:40 pm - 8:00 pm
Rosa Puertollano-Moro (National Institutes of Health, USA)
"Emerging New Roles of Lysosomes in Cellular Adaptation to Stress"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Maria Antonietta De Matteis (Telethon Institute of Genetics and Medicine (TIGEM), Italy)
"The Lysosome Cargo Response"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Suzanne Pfeffer (Stanford University School of Medicine, USA)
"Genome Wide Interrogation of Extracellular Vesicle Formation"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jen Liou (University of Texas Southwestern Medical Center, USA)
"Phosphoinositide Identities of Mammalian Late Endocytic Compartments Revealed by Novel Membrane Contact Site Probes"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lysosomal Biogenesis and Autophagy: Mechanisms to Neurological Diseases
Discussion Leaders: Victor Faundez (Emory University, USA) and Amy Kiger (University of California, San Diego, USA)
9:00 am - 9:20 am
Alexey Merz (University of Washington, USA)
"Coordination of AP-3 and Other Coat Complexes in Endolysosomal Traffic"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Shawn Ferguson (Yale University School of Medicine, USA)
"Lysosome Function, Dysfunction and Neurodegenerative Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Gilbert Di Paolo (Denali Therapeutics, USA)
"Role of Endolysosomal Dysfunction in Neurodegeneration"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Xiaochen Wang (Chinese Academy of Sciences, China)
"Regulation of Lysosome Activity During C. elegans Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Maho Hamasaki (Osaka University, Japan)
"Insights into Membrane Dynamics in the Autophagic Pathway"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Roberto Botelho (Ryerson University, Canada)
"Enhanced mRNA Translation Rapidly Expands the Lysosome Population During Phagocyte Activation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Hongyuan Yang (University New South Wales, Australia)
"ORP1L Regulates Cholesterol Exit from Late Endosomes and Lysosomes, via an Unexpected Role for Phosphatidylinositol Bisphosphates"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom) and Christopher Burd (Yale School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Endocytosis: Basic Mechanisms, Signaling, and Diabetes
Discussion Leaders: Julie Donaldson (National Heart, Lung, and Blood Institute, NIH, USA) and Amira Klip (University of Toronto, Canada)
7:30 pm - 7:50 pm
Marko Kaksonen (University of Geneva, Switzerland)
"Imaging the Molecular Mechanisms of Clathrin-Mediated Endocytosis in Yeast"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Sandra Schmid (University of Texas Southwestern Medical Center, USA)
"Regulation of Clathrin-Mediated Endocytosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Mark von Zastrow (University of California, San Francisco, USA)
"Role of the Endocytic Network as a Receptor-Mediated Signal Processor"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Timothy McGraw (Weill Cornell Medicine, USA)
"From Regulated Vesicle Trafficking to Whole Body Glucose Homeostasis"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Autophagy, Endocytosis and Exosomes: The Ins and Outs of Cancer and Immunity
Discussion Leaders: Norma Andrews (University of Maryland, USA) and Michael Marks (Children's Hospital of Philadelphia, USA)
9:00 am - 9:20 am
Carole Parent (University of Michigan, USA)
"Exosomes as Key Regulators of Neutrophil Chemotaxis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Katja Simon (University of Oxford, United Kingdom)
"Novel Roles for Autophagy in Immunity and Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Randy Schekman (University of California, Berkeley, USA)
"RNA Sorting and Secretion in Exosomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Joanne Engel (University of California, San Francisco, USA)
"Chlamydia trachomatis IncE Mimics a Native Interaction Between the CI-MPR and SNX5 to Disrupt Retromer-Mediated Restriction During Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Ann Wehman (University of Wuerzburg, Germany)
"Extracellular Vesicle Budding and Clearance"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Yanzhuang Wang (University of Michigan, USA)
"GRASP55 Senses Energy Deprivation Through O-GlcNAcylatin to Promote Autophagosome-Lysosome Fusion"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Stéphane Vassilopoulos (Sorbonne University, France)
"Clathrin Plaques Form Mechanotransducing Platforms"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Traffic: Unexpected Pathways and Roles in Organismal Physiology
Discussion Leaders: Graca Raposo (Institut Curie, France) and Liz Miller (MRC Laboratory of Molecular Biology, United Kingdom)
7:30 pm - 7:50 pm
Alexander Sorkin (University of Pittsburgh School of Medicine, USA)
"EFG Receptor Endocytosis in Mouse Tumor Models In Vivo : Mechanisms and Role in Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Roberto Weigert (National Cancer Institute, NIH, USA)
"Intravital Imaging of Regulated Secretion"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Frances Brodsky (University College London, United Kingdom)
"Evolution and Loss of Genes Encoding Clathrin Subunits"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Jimena Giudice (University of North Carolina at Chapel Hill, USA)
"Alternative Splicing Regulation of the Clathrin Heavy Chain Impacts Muscle Physiology and Protects Hearts from Failure"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Steve Caplan (University of Nebraska Medical Center, USA)
"Implications for Membrane Trafficking on the Centrosome, a Membrane-Free Organelle"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cellular Integration via Organelle Contact Sites and Phosphoinositide Signaling
Discussion Leaders: Peter Cullen (University of Bristol, United Kingdom) and Fred Maxfield (Weill Cornell Medicine, USA)
9:00 am - 9:20 am
Karin Reinisch (Yale University School of Medicine, USA)
"Lipid Homeostasis at the Vacuole/Lysosome"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sergio Grinstein (The Hospital for Sick Children, Canada)
"Molecular Determinants of Phagosome Formation and Maturation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Benoît Kornmann (ETH Zurich, Switzerland)
"Vps13-Mediated Mitochondria-Lysosome Cross-Talk"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Christina Mitchell (Monash University, Australia)
"Regulation of PI(4,5)P2 on Autolysosomes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Heidi McBride (McGill University, Canada)
"Investigating the Mechanism of Iron Transfer to Mitochondria"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Mike Henne (University of Texas Southwestern Medical Center, USA)
"Spatially Organized Lipid Droplets and Their Roles in Stress Response"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Elizabeth Conibear (University of British Columbia, Canada)
"Organelle-Specific Targeting of Vps13"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Late-Breaking Topics
Discussion Leaders: Mary Munson (University of Massachusetts Medical School, USA) and Judith Klumperman (University Medical Center Utrecht, The Netherlands)
7:30 pm - 7:50 pm
Tomas Kirchhausen (Harvard Medical School, USA)
"Imaging Subcellular Dynamics in Multicellular Organisms"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Kem Sochacki (National Heart, Lung, and Blood Institute, NIH, USA)
"Assembling a Growing Clathrin Coated Pit from Super-Resolution Correlative LIght and Electron Microscopy"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Natalya Leneva (Cambridge Institute for Medical Research, University of Cambridge, United Kingdom)
"The Architecture of the Membrane Assembled Retromer Coat"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Christos Gournas (Université Libre de Bruxelles, Belgium)
"Conformatin-Dependent Partitioning of Nutrient Transporters into Endocytosis-Protective Membrane Domains"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Greg Lavieu (Institut Curie / INSERM, France)
"Extracellular Vesicle Uptake in a Cell Free Extract"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Christophe Lamaze (Institut Curie, France)
"Selective Control of JAK/STAT Signaling by Caveolae Mechanics"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sorting in the Endosomal Network
Discussion Leaders: Phyllis Hanson (Washington University in St. Louis, USA) and Christopher Burd (Yale School of Medicine, USA)
9:00 am - 9:20 am
Jeanne Stachowiak (The University of Texas at Austin, USA)
"Intrinsically Disordered Domains as Physical Drivers of Membrane Vesiculation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Scott Emr (Weill Institute for Cell and Molecular Biology, Cornell University, USA)
"There Are No Dead Ends in Membrane Trafficking"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Robert Piper (University of Iowa, USA)
"How Ubiquitin Mediates Entry into Endosomes"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Benjamin Glick (University of Chicago, USA)
"Kinetic Mapping of Golgi and Endosome Dynamics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
James Hurley (University of California, Berkeley, USA)
"A Cargo-Selective Switch for AP-1 Coat Assembly"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Kenneth Madsen (University of Copenhagen, Denmark)
"GPCRs Shape Their Own Destiny in Constitutive Endocytosis Through Surface Activitity of Helix 8"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Allyson O'Donnell (Duquesne University, USA)
"Evolutionary Rate Covariation as a Predictive Tool to Identify Arrestin-Cargo Pairs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Membrane Fusion
Discussion Leader: Lois Weisman (University of Michigan, USA)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:45 pm
William Wickner (Dartmouth College, USA)
"Membrane Fusion, by 5 Lipids, 4 SNAREs, 3 Chaperones, 2 Nucleotides, and a Rab, All Dancing in a Ring"
8:45 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure