Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Lysosomes and the Control of Cellular Metabolism
Discussion Leaders: Suzanne Pfeffer (Stanford University School of Medicine, United States) and Robert Piper (University of Iowa, United States)
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:20 pm
Peter Cullen (University of Bristol, United Kingdom)
"Molecular Mechanisms of Mammalian Endosomal Cargo Sorting"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Spencer Freeman (The Hospital for Sick Children, Canada)
"Solute Fluxes that Control Endomembrane Tension and Dynamics"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Andrea Ballabio (Telethon Institute of Genetics and Medicine (TIGEM), Italy)
"Close Encounters at the Lysosomal Surface"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Endo-Lysosomal System and Disease
Discussion Leader: Scott Emr (Cornell University, United States)
9:00 am - 9:20 am
Harald Stenmark (Oslo University Hospital, Norway)
"Dealing with Dysfunctional Endosomes and Lysosomes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Rushika Perera (University of California, San Francisco, United States)
"Unraveling How Autophagy and the Lysosome Mediate Adaptation to Stress in Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Francesca Peri (University of Zurich, Switzerland)
"In the Belly of the Microglia: Towards a Quantitative Dynamic Understanding of Neuronal Degradation in vivo "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Maria Ioannou (University of Alberta, Canada)
"Exocytosis of Lipids Protect Neurons from Ferroptosis"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Swetha Gowrishankar (University of Illinois at Chicago, United States)
"AP-4 Regulates Neuronal Lysosome Composition, Function and Transport Via Regulating Export of Critical Lysosome Receptor Proteins at The Trans-Golgi Network"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Juan Bonifacino (National Institute of Child Health and Human Development, NIH, United States)
"Axonal Defects Caused by Mutations in the Lysosome-Movement Machinery"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Joseph Mindell (NINDS, United States)
"Fat Chances: How Signaling Lipids Influence Lysosomal pH via the Chloride Transporter ClC-7"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Sandra Paiva (University of Minho, Portugal) and Phyllis Hanson (University of Michigan Medical School, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Entering Cells
Discussion Leaders: Frances Brodsky (University College London, United Kingdom)
7:30 pm - 7:50 pm
Gunther Hollopeter (Cornell University, United States)
"Allosteric Regulation of the AP2 Clathrin Adaptor Complex"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Margaret Johnson (Johns Hopkins University, United States)
"Determinants of Spontaneous Assembly and Disassembly of Clathrin Coats on Membranes"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Rick Hooy (UC Berkeley, United States)
"Structure of an AP-1 Tubular Membrane Coat That Sequesters MHC-I in HIV-1 Infection"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Michael Bassik (Stanford University, United States)
"Development of High-Throughput Functional Genomics Tools to Identify Regulators of Endocytosis and Phagocytosis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Christophe Lamaze (Institut Curie, France)
"Remote Control of Signaling Through Caveolae Mechanics"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Claudia Matthaeus (National Heart, Lung, and Blood Institute, United States)
"From Flat to Bulb - Novel Insights in Caveolae Membrane Curvature and Endocytosis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Inter-Organelle and Inter-Cellular Communication
Discussion Leaders: Sandra Paiva (University of Minho, Portugal)
9:00 am - 9:20 am
Meng Wang (Baylor College of Medicine / Howard Hughes Medical Institute, United States)
"Lysosomal Signals in Longevity Regulation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Roberto Zoncu (University of California, Berkeley, United States)
"Cholesterol Sensing by the mTORC1 Pathway"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Yvette Wong (Northwestern University, United States)
" Dynamics and Functions of Mitochondria-Lysosome Contacts in Health and Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Sho Suzuki (Cornell University, United States)
"The Role of Lipid Transfer Proteins in ESCRT-Mediated Sorting"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Guillaume van Niel (INSERM, France)
"Live Imaging of Extracellular Vesicles in vivo "
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Ann Wehman (University of Denver, United States)
"TORC1, BORC, and ARL-8 Cycling Drive Vesiculation of Cell Corpse Phagolysosomes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Min Wu (Yale University, United States)
"Emergent Properties of the Cell Cortex"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Roles of the Endosomal Network in Organismal Physiology
Discussion Leaders: Tomas Kirchhausen (Harvard Medical School, United States) and Margaret Robinson (University of Cambridge, United Kingdom)
7:30 pm - 7:50 pm
Max Gutierrez (The Francis Crick Institute, United Kingdom)
"Endolysosomal Damage in Macrophage Immune Function"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Avital Rodal (Brandeis University, United States)
"Routing and Remodeling Presynaptic Membranes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Alessandro Luciani (Institute of Physiology, University of Zurich, Switzerland)
"Lysosome Directs Cell-Fate Decisions in the Kidney"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Anja Zeigerer (Helmholtz Center Munich GmbH, Germany)
"Vps37a Regulates Hepatic Glucose Production by Controlling Glucagon Receptor Localization to Endosomes"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Michael Marks (Children's Hospital of Philadelphia, United States)
"Control of Endosomal Tubule Dynamics in Melanosome Biogenesis"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Lysosome, Autophagy and Cellular Catabolism
Discussion Leaders: Markus Babst (University of Utah, United States)
9:00 am - 9:20 am
Thomas Melia (Yale University, United States)
"Molecular Mechanisms of Autophagosome Biogenesis"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Leon Murphy (Casma Therapeutics, United States)
"Single Membrane ATG8 Conjugation and The Regulation of TFEB"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Anne Simonsen (University of Oslo, Norway)
"Regulation of Autophagy and Mitochondrial Homeostasis by Lipid-Binding Proteins"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Eugenia Almacellas (Molecular Cell Biology of Autophagy Laboratory, The Francis Crick Institute, United Kingdom)
"PTPN9 at the Crossroad of Autophagy and Endocytic Trafficking"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
Michael Overholtzer (Memorial Sloan Kettering Cancer Center, United States)
"Mechanisms of Lysosome Turnover"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Patricia Kane (Upstate Medical University, State University of New York, United States)
"Spatial and Temporal Regulation of V-ATPases By Phosphoinositides"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ming Li (University of Michigan, United States)
"GCAF Regulates Lysosome Biogenesis by Activating the Mannose-6-Phosphate Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sabrina Jabs (Kiel University, Germany)
"LYSET - a Key Protein in the Biogenesis of Lysosomes and Viral Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Methods and Late-Breaking Topics
Discussion Leader: Alexander Sorkin (University of Pittsburgh School of Medicine, United States)
7:30 pm - 7:40 pm
Late-Breaking Topic
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Trude Flo (Norwegian University of Science and Technology / Boston Childrens hospital, United States)
"The Inner Life of Mycobacterium Infected Macrophages"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Yamuna Krishnan (University of Chicago, United States)
"New Advances in Mapping Ions in Lysosomes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Braden Lobingier (Oregon Health Sciences University, United States)
"A Genome-wide CRISPR Interference Screen Reveals a Role for RME-8 in Opioid Receptor Regulation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Nebojsa Jukic (AMOLF, The Netherlands)
"Snf7 Spirals Sense and Alter Membrane Curvature"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
James Hurley (University of California, Berkeley, United States)
"Switching TFEB off: Its Way More Complicated than You Thought"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Sorting and Trafficking in the Endosomal Network
Discussion Leaders: Manoj Puthenveedu (University of Michigan, United States) and Lauren Jackson (Vanderbilt University, United States)
9:00 am - 9:20 am
Lois Weisman (University of Michigan, United States)
"Insights Into How Phosphoinositide Lipids Order Complex Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Elizabeth Conibear (University of British Columbia, Canada)
"A New Rab GEF-containing SNX-BAR Coat at the Yeast Endosome"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Benjamin Glick (University of Chicago, United States)
"SNARE and Tether Availability Constrain the Timing of Endocytic Vesicle Fusion"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Chris MacDonald (University of york, United Kingdom)
"Recycling of Cell Surface Membrane Proteins from Yeast Endosomes is Regulated by Ubiquitinated Ist1"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Stefanie Schmieder (BOSTON CHILDREN'S HOSPITAL, United States)
"Structural Basis for Acyl Chain Control Over Glycosphingolipid Sorting and Vesicular Trafficking"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Andreas Mayer (Université de Lausanne, Switzerland)
"PROPPINs and Retromer in Protein Exit From Endosomes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Anwesha Sanyal (Boston Children's Hospital and Harvard Medical School, United States)
"Retromer and Breaks"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Christian Ungermann (Osnabrueck University, Germany)
"Structure of the Lysosomal Membrane Fusion Machinery"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Lysosome-Like Organelles
Discussion Leader: Philip Stahl (Washington University School of Medicine, United States)
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:45 pm
Graca Raposo (Institut Curie, France)
"Watching the Cell: Lysosomes and Related Organelles"
8:45 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure