Mechanisms, Molecules and Therapeutic Opportunities Across the Endolysosomal Pathway

June 16 - 21, 2024

Chair

Vice Chair

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Lysosomes and Endocytosis GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

An exciting program will highlight late-breaking topics related to mechanism, physiology, and pathophysiology of the endolysosomal pathway. Major topics below will showcase advances across many systems with particular focus on rapidly evolving areas including lysosomal function in the nervous system and role in neurodegeneration, pathogen entry and effects on the endolysosomal system, autophagy, mechanisms of endocytosis and membrane remodeling, and more. Notable sessions will include a discussion of new technologies and therapeutic opportunities and a keynote lecture on the importance of protein-lipid interactions in regulating membrane dynamics. The final program will feature many abstract-selected talks from a diverse set of speakers. Please apply by April 15 for consideration.

Related Meeting

This GRC will be held in conjunction with the "Lysosomes and Endocytosis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Endolysosomal Function in the Nervous System Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Lysosomal Pathways in Synaptic Signaling Between Neurons and Astrocytes"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Bridge-like Lipid Transport Proteins in the Endo-Lysosomal System"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 9:05 pm	"Role of the Endocytic Pathway in Sculpting GPCR Signaling"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"The Actin-Spectrin Submembrane Scaffold Restricts Endocytosis Along Proximal Axons"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Understanding Lysosomal Physiology and Disease Discussion Leader:
9:00 am - 9:20 am	"Lysosome Adaptations That Confer Parkinson's Disease Risk"
9:20 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Reversible Disassembly of V-ATPases in Aging and Neurodegenerative Disease"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Genetics to therapeutics: modulation of TMEM175 as Parkinson’s Disease therapeutics to enhance lysosomal function"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"LRRK2 Kinase Activity Regulates Parkinson’s Disease-Relevant Lipids at the Lysosome"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Intra-Lysosomal Lipid Metabolism: Builders, Degraders and Regulators"
11:05 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Mechanisms of Lysosomal Degradation of Sphingolipids"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"A Peroxisome-Derived Lipid and its Regulation of Lysosomal Function"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Lysosomal GPCR-Like Protein in Nutrient Sensing and Cellular Growth Control"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Structural Biology of Amino Acid Sensing Mechanisms in mTORC1 Signaling"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lipid Trafficking and Regulation Discussion Leader:
7:30 pm - 7:50 pm	"Transbilayer Lipid Dynamics and Signalling in Lysosomal Repair"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"ER-Localized Sorting Nexins Support Lipid Droplet Growth at ER-Endolysosome-Lipid Droplet Contacts"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Inter-Organelle Lipid Trafficking"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Mutual Dependence of Osbp and PI4KII in the Maturation of Regulated Secretory Granules"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Global Identification of Integral Membrane Proteins that Require Retromer for Their Sorting in Neuronal Systems"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Navigating Cellular Barriers: Pathogens, Phagosomes, and Beyond Discussion Leader:
9:00 am - 9:20 am	"Microbial Manipulation of Host Membranes"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Enhanced Viral Transmission through Autophagosomal and Lysosomal en bloc Egress"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"The Host Endocytic Recycling Pathway is Impaired During Influenza A Virus Infection to Form Liquid Organelles"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Role of Membrane Cholesterol Accessibility in Host-Pathogen Interactions"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"The Regulation of Phagosomal Maturation by PIKfyve/PI(3,5)P₂"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Mechanisms of Autophagic-Lysosomal Dysfunction Induced by Bacterial Extracellular Membrane Vesicles"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"From Blobs to Atoms and Back to Blobs: Using Cryo-EM to Understand the Structure of Caveolin"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	The Lysosome, Autophagy, and Cellular Catabolism Discussion Leader:
7:30 pm - 7:40 pm	"Multi-Functional ARF1 Compartments Mediate Secretory and Endocytic Trafficking by Maturing into Recycling Endosomes"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"mRNA Translation in Proximity to Forming Autophagosomes Promotes Sustained Autophagy"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Endolysosomal Trafficking of BNIP3 Couples Lipid Peroxidation and Mitophagy"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Targeting the Fip200 Initiation Complex to Direct Selective Autophagy and Activate Bulk Autophagy"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"The Role of Non-Canonical Autophagy as a Lysosome Stress Response"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Lysosomal Damage Induces Stress Granule Formation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Endolysosomal Function and Dysfunction in Neurodegeneration Discussion Leader:
9:00 am - 9:20 am	"Proton Release Mechanisms in the Lysosome"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Lysosomal Proteases and pH Regulation in Neurodegenerative Disease"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Elucidating Endolysosomal Mechanisms in Neurodegeneration Using Unbiased CRISPR Screens"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Physiological and Pathological Functions of TMEM106B, a Lysosomal Membrane Protein Associated With Neurodegeneration"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Human Genetics Implicates Efferocytosis in Myeloid Cells as a Disease Risk Hub for Alzheimer's Disease"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Dysfunctional Lysosomes in Batten Disease Impact the Lipid Composition of the Nuclear Envelope and Activate Apoptotic Signaling Pathways"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"In Situ Snapshots of Protein Aggregate Turnover"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Technologies and Therapeutic Opportunities Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Constitutive Endolysosomal Perforation in Neurons"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Isolation of Endosomal Subpopulations to Characterize Endosomal Escape During RNA Delivery"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Endolysosomal Escape During Exogenous Antigen Presentation by Dendritic Cells"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Discovery of a Novel Niemann Pick type C (NPC) Disease Modifier and Development Towards its Clinical Application"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Subversion of Host Lysosomal Proteolysis by Coxiella Burnetii"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"JIP4 Controls Cystinosin Stability at Lysosomes"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Endocytosis and Mechanisms of Intracellular Trafficking Discussion Leaders: and
9:00 am - 9:20 am	"The HOPS Complex: Integrating Lysosomal Trafficking Pathways"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"The Role of Rab40-Dependent Ubiquitylation in Regulating Endocytic Recycling and Activation of Rap GTPases During Cell Migration"
9:50 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Regulation of Distinct Phases of EGFR Signaling by Tetraspanin and Clathrin Nanodomains at the Cell Surface"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Orchestrated Synaptic Nano-Architectures for Efficient Synaptic Vesicle Endocytosis"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"In Vitro Dynamics of Membrane Remodelling by Archeal ESCRT-III"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Coordination Between ESCRT Function and Rab Conversion During Endosome Maturation"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Cytoskeleton-Driven Spatialization of a Lysosome-Like Organelle Contributes to Genome Protection"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Cell Processes and the Programming of Trafficking"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Protein-Lipid Interactions in Regulation of Cellular Membrane Dynamics Discussion Leader:
7:30 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:50 pm	"Converging Mechanisms of Lysosome Repair"
8:50 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute On Aging of the National Institutes of Health under Award Number R13AG087662. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Lysosomes and Endocytosis

Mechanisms, Molecules and Therapeutic Opportunities Across the Endolysosomal Pathway

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